Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Natalia M. Felitsyn"'
Publikováno v:
Journal of Neurochemistry. 100:429-436
Dichloroacetate (DCA) is an investigational drug for genetic mitochondrial diseases whose use has been mitigated by reversible peripheral neuropathy. We investigated the mechanism of DCA neurotoxicity using cultured rat Schwann cells (SCs) and dorsal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e1a343be398120273898074dad0943
https://doi.org/10.1111/j.1471-4159.2006.04248.x
https://doi.org/10.1111/j.1471-4159.2006.04248.x
Controlled Clinical Trial of Dichloroacetate for Treatment of Congenital Lactic Acidosis in Children
Autor:
Janet H. Silverstein, Richard E. Neiberger, Douglas W. Theriaque, Alan D. Hutson, Robin L. Gilmore, Jonathan J. Shuster, Douglas S. Kerr, Paul R. Carney, Eileen M. Fennell, Albert L. Shroads, Leigh Ann Perkins, George N. Henderson, Ronald G. Quisling, Natalia M. Felitsyn, S. Terri Bunch, Melvin Greer, Carie L. Barnes, Ralph G. O'Brien, Edward Valenstein, Peter W. Stacpoole
Publikováno v:
Pediatrics. 117:1519-1531
OBJECTIVE. Open-label studies indicate that oral dichloroacetate (DCA) may be effective in treating patients with congenital lactic acidosis. We tested this hypothesis by conducting the first double-blind, randomized, control trial of DCA in this dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ad86cb1ca492ff04a9f55cd183b5d5
https://doi.org/10.1542/peds.2005-1226
https://doi.org/10.1542/peds.2005-1226
Publikováno v:
Clinica Chimica Acta. 350:219-230
Several acquired and congenital human disorders perturb the concentrations of delta-aminolevulinate (delta-ALA), creatinine and tyrosine in biological fluids. There is currently no facile, sensitive and specific method to measure these analytes simul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fa6fce2abff8c891e4fea0cfae524c
https://doi.org/10.1016/j.cccn.2004.08.009
https://doi.org/10.1016/j.cccn.2004.08.009
Publikováno v:
Journal of Neurochemistry.
Delta-aminolevulinic acid (delta-ALA) is a heme precursor implicated in neurological complications associated with porphyria and tyrosinemia type I. Delta-ALA is also elevated in the urine of animals and patients treated with the investigational drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3815f484c13f84499078496bf507bcbb
https://doi.org/10.1111/j.1471-4159.2008.05552.x
https://doi.org/10.1111/j.1471-4159.2008.05552.x
Autor:
Nigel A. Calcutt, Peter W. Stacpoole, Lucia Notterpek, Natalia M. Felitsyn, Albert L. Shroads
Publikováno v:
Mitochondrion. 6:17-18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27a65d0e4198b4c05838cbc4a76625c0
https://doi.org/10.1016/j.mito.2006.08.042
https://doi.org/10.1016/j.mito.2006.08.042