Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

Autor: Julia R Clarke, Natalia M Lyra e Silva, Claudia P Figueiredo, Rudimar L Frozza, Jose H Ledo, Danielle Beckman, Carlos K Katashima, Daniela Razolli, Bruno M Carvalho, Renata Frazão, Marina A Silveira, Felipe C Ribeiro, Theresa R Bomfim, Fernanda S Neves, William L Klein, Rodrigo Medeiros, Frank M LaFerla, Jose B Carvalheira, Mario J Saad, Douglas P Munoz, Licio A Velloso, Sergio T Ferreira, Fernanda G De Felice

Publikováno v: EMBO Molecular Medicine, Vol 7, Iss 2, Pp 190-210 (2015)

Abstract Alzheimer's disease (AD) is associated with peripheral metabolic disorders. Clinical/epidemiological data indicate increased risk of diabetes in AD patients. Here, we show that intracerebroventricular infusion of AD‐associated Aβ oligomer

Externí odkaz: https://doaj.org/article/bfe3876cdb4d49808c5c97e93ba78817

Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease

Autor: Natalia M. Lyra e Silva, Rafaella A. Gonçalves, Tharick A. Pascoal, Ricardo A. S. Lima-Filho, Elisa de Paula França Resende, Erica L. M. Vieira, Antonio L. Teixeira, Leonardo C. de Souza, Julyanna A. Peny, Juliana T. S. Fortuna, Isadora C. Furigo, Debora Hashiguchi, Vivian S. Miya-Coreixas, Julia R. Clarke, Jose F. Abisambra, Beatriz M. Longo, Jose Donato, Paul E. Fraser, Pedro Rosa-Neto, Paulo Caramelli, Sergio T. Ferreira, Fernanda G. De Felice

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract Alzheimer’s disease (AD) is associated with memory impairment and altered peripheral metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery metabolic axis plays a role in AD pathophysiology. The activation of

Externí odkaz: https://doaj.org/article/17556201da0949e79e2b1a92c14e9d0c

Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease

Autor: Tharick A. Pascoal, Julyanna A. Peny, Elisa de Paula França Resende, Érica Leandro Marciano Vieira, Natalia M. Lyra e Silva, Isadora C. Furigo, Julia R. Clarke, Ricardo A.S. Lima-Filho, Antônio Lúcio Teixeira, Beatriz M. Longo, Pedro Rosa-Neto, Debora Hashiguchi, Jose Donato, Juliana T.S. Fortuna, Vivian S. Miya-Coreixas, Paulo Caramelli, Paul E. Fraser, Fernanda G. De Felice, Rafaella Araujo Gonçalves, Leonardo Cruz de Souza, Jose F. Abisambra, Sergio T. Ferreira

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-15 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Translational Psychiatry

Alzheimer’s disease (AD) is associated with memory impairment and altered peripheral metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery metabolic axis plays a role in AD pathophysiology. The activation of pro-infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0aa36a51f417a787b71c8e35af6b79a
https://doaj.org/article/17556201da0949e79e2b1a92c14e9d0c

Dysregulation of placental ABC transporters in a murine model of malaria-induced preterm labor

Autor: Guinever E. Imperio, Stephen G. Matthews, João Luiz Silva-Filho, Enrrico Bloise, Tania M. Ortiga-Carvalho, Pedro M. Pimentel-Coelho, Natalia M. Lyra e Silva, Flavia Fonseca Bloise, A.A.S. Pinheiro, Klaus N. Fontes, Mila W. Reginatto, Victoria R. S. Monteiro, Cherley Borba Vieira de Andrade

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports

Malaria in Pregnancy (MiP) is characterized by placental accumulation of Plasmodium-infected erythrocytes, intrauterine growth restriction (IUGR) and preterm delivery (PTD). Placental ATP-binding cassette (ABC) transporters mediate the efflux of nutr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585b5dab699704c4dafc5558a361fe87
http://link.springer.com/article/10.1038/s41598-019-47865-3

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease

Autor: Natalia M. Lyra e Silva, Matthias Gralle, William L. Klein, Jordano Brito-Moreira, Christian Hölscher, Suelen Adriani Marques, Douglas P. Munoz, Juliana F.S. Vital, Leticia Forny-Germano, Sergio T. Ferreira, Susan E. Boehnke, Andre F. Batista, Julia R. Clarke, Jean-Christophe Houzel, Andrew Winterborn, Fernanda G. De Felice, Brian C. Coe, Ana Maria Blanco Martinez, Ann Lablans

Publikováno v: The Journal of Pathology. 245:85-100

Alzheimer's disease (AD) is a devastating neurological disorder that still lacks an effective treatment, and this has stimulated an intense pursuit of disease-modifying therapeutics. Given the increasingly recognized link between AD and defective bra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8726c69918087428f2e13d65631ba2b6
https://doi.org/10.1002/path.5056