Výsledky vyhledávání - "Natalia Lapteva"

Akademický článek

Allogeneic, off-the-shelf, SARS-CoV-2-specific T cells (ALVR109) for the treatment of COVID-19 in high-risk patients

Autor: Spyridoula Vasileiou, LaQuisa Hill, Manik Kuvalekar, Aster G. Workineh, Ayumi Watanabe, Yovana Velazquez, Suhasini Lulla, Kimberly Mooney, Natalia Lapteva, Bambi J. Grilley, Helen E. Heslop, Cliona M. Rooney, Malcolm K. Brenner, Todd N. Eagar, George Carrum, Kevin A. Grimes, Ann M. Leen, Premal Lulla

Publikováno v: Haematologica, Vol 108, Iss 7 (2022)

Defects in T-cell immunity to SARS-CoV-2 have been linked to an increased risk of severe COVID-19 (even after vaccination), persistent viral shedding and the emergence of more virulent viral variants. To address this T-cell deficit, we sought to prep

Externí odkaz: https://doaj.org/article/fe01c9fbf22e4de38523e9244e616c26

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Akademický článek

Multi-antigen-targeted T-cell therapy to treat patients with relapsed/refractory breast cancer

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 14 (2022)

Purpose: Adoptively transferred, ex vivo expanded multi-antigen-targeted T cells (multiTAA-T) represent a new, potentially effective, and nontoxic therapeutic approach for patients with breast cancer (BC). In this first-in-human trial, we investigate

Externí odkaz: https://doaj.org/article/d2a1cea135ca47b2969fd4c6813e68ff

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Akademický článek

Chimeric Antigen Receptor Signaling Domains Differentially Regulate Proliferation and Native T Cell Receptor Function in Virus-Specific T Cells

Autor: Bilal Omer, Paul A. Castillo, Haruko Tashiro, Thomas Shum, Mai T. A. Huynh, Mara Cardenas, Miyuki Tanaka, Andrew Lewis, Tim Sauer, Robin Parihar, Natalia Lapteva, Michael Schmueck-Henneresse, Malini Mukherjee, Stephen Gottschalk, Cliona M. Rooney

Publikováno v: Frontiers in Medicine, Vol 5 (2018)

The efficacy of T cells expressing chimeric antigen receptors (CARs) for solid tumors has been limited by insufficient CAR T cell expansion and persistence. The use of virus-specific T cells (VSTs) as carriers for CARs may overcome this limitation si

Externí odkaz: https://doaj.org/article/b94065e18d6045f89d2146ca4b8029aa

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Akademický článek

Optimization Manufacture of Virus- and Tumor-Specific T Cells

Autor: Natalia Lapteva, Juan F. Vera

Publikováno v: Stem Cells International, Vol 2011 (2011)

Although ex vivo expanded T cells are currently widely used in pre-clinical and clinical trials, the complexity of manufacture remains a major impediment for broader application. In this review we discuss current protocols for the ex vivo expansion o

Externí odkaz: https://doaj.org/article/21b310e1df30454789744d09920937f6

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Supplementary Data from NK Cells Expressing a Chimeric Activating Receptor Eliminate MDSCs and Rescue Impaired CAR-T Cell Activity against Solid Tumors

Autor: Cliona M. Rooney, Stephen M. Gottschalk, Leonid S. Metelitsa, Natalia Lapteva, Bilal Omer, Mai Huynh, Charlotte Rivas, Robin Parihar

Fig. S1 shows characterization of GD2-specific CAR-T cells. Fig. S2 shows characterization of human MDSCs. Fig. S3 shows characterization of TME xenograft model. Fig. S4 shows GD2.CAR-T cell homing and infiltration into MDSC-containing tumors after N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172e235632002cb49c80bddf805cc570
https://doi.org/10.1158/2326-6066.22542165.v1

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Data from NK Cells Expressing a Chimeric Activating Receptor Eliminate MDSCs and Rescue Impaired CAR-T Cell Activity against Solid Tumors

Autor: Cliona M. Rooney, Stephen M. Gottschalk, Leonid S. Metelitsa, Natalia Lapteva, Bilal Omer, Mai Huynh, Charlotte Rivas, Robin Parihar

Solid tumors are refractory to cellular immunotherapies in part because they contain suppressive immune effectors such as myeloid-derived suppressor cells (MDSCs) that inhibit cytotoxic lymphocytes. Strategies to reverse the suppressive tumor microen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee879a054753ff8c7775a258778f03b
https://doi.org/10.1158/2326-6066.c.6549822.v1

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