Zobrazeno 1 - 10 of 125 pro vyhledávání: '"Natalia Lapteva"'
1
Akademický článek
Allogeneic, off-the-shelf, SARS-CoV-2-specific T cells (ALVR109) for the treatment of COVID-19 in high-risk patients
Autor: Spyridoula Vasileiou, LaQuisa Hill, Manik Kuvalekar, Aster G. Workineh, Ayumi Watanabe, Yovana Velazquez, Suhasini Lulla, Kimberly Mooney, Natalia Lapteva, Bambi J. Grilley, Helen E. Heslop, Cliona M. Rooney, Malcolm K. Brenner, Todd N. Eagar, George Carrum, Kevin A. Grimes, Ann M. Leen, Premal Lulla
Publikováno v: Haematologica, Vol 108, Iss 7 (2022)
Defects in T-cell immunity to SARS-CoV-2 have been linked to an increased risk of severe COVID-19 (even after vaccination), persistent viral shedding and the emergence of more virulent viral variants. To address this T-cell deficit, we sought to prep
Externí odkaz: https://doaj.org/article/fe01c9fbf22e4de38523e9244e616c26
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2
Akademický článek
Multi-antigen-targeted T-cell therapy to treat patients with relapsed/refractory breast cancer
Autor: Valentina Hoyos, Spyridoula Vasileiou, Manik Kuvalekar, Ayumi Watanabe, Ifigeneia Tzannou, Yovana Velazquez, Matthew French-Kim, Wingchi Leung, Suhasini Lulla, Catherine Robertson, Claudette Foreman, Tao Wang, Shaun Bulsara, Natalia Lapteva, Bambi Grilley, Matthew Ellis, Charles Kent Osborne, Angela Coscio, Julie Nangia, Helen E. Heslop, Cliona M. Rooney, Juan F. Vera, Premal Lulla, Mothaffar Rimawi, Ann M. Leen
Publikováno v: Therapeutic Advances in Medical Oncology, Vol 14 (2022)
Purpose: Adoptively transferred, ex vivo expanded multi-antigen-targeted T cells (multiTAA-T) represent a new, potentially effective, and nontoxic therapeutic approach for patients with breast cancer (BC). In this first-in-human trial, we investigate
Externí odkaz: https://doaj.org/article/d2a1cea135ca47b2969fd4c6813e68ff
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4
Akademický článek
Erinnerungsort Minsk.
Autor: Lapteva, Natalia, Tarasevich, Larysa
Publikováno v: Materialien und Studien Deutsch als Fremd- und Zweitsprache. 2022, Issue 111, Part 2, p155-156. 2p.
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5
Supplementary Data from NK Cells Expressing a Chimeric Activating Receptor Eliminate MDSCs and Rescue Impaired CAR-T Cell Activity against Solid Tumors
Autor: Cliona M. Rooney, Stephen M. Gottschalk, Leonid S. Metelitsa, Natalia Lapteva, Bilal Omer, Mai Huynh, Charlotte Rivas, Robin Parihar
Fig. S1 shows characterization of GD2-specific CAR-T cells. Fig. S2 shows characterization of human MDSCs. Fig. S3 shows characterization of TME xenograft model. Fig. S4 shows GD2.CAR-T cell homing and infiltration into MDSC-containing tumors after N
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172e235632002cb49c80bddf805cc570
https://doi.org/10.1158/2326-6066.22542165.v1
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6
Data from NK Cells Expressing a Chimeric Activating Receptor Eliminate MDSCs and Rescue Impaired CAR-T Cell Activity against Solid Tumors
Autor: Cliona M. Rooney, Stephen M. Gottschalk, Leonid S. Metelitsa, Natalia Lapteva, Bilal Omer, Mai Huynh, Charlotte Rivas, Robin Parihar
Solid tumors are refractory to cellular immunotherapies in part because they contain suppressive immune effectors such as myeloid-derived suppressor cells (MDSCs) that inhibit cytotoxic lymphocytes. Strategies to reverse the suppressive tumor microen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee879a054753ff8c7775a258778f03b
https://doi.org/10.1158/2326-6066.c.6549822.v1
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