Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Natalia Khalatyan"'
Autor:
Sehyoun Yoon, Marc Dos Santos, Marc P. Forrest, Christopher P. Pratt, Natalia Khalatyan, Peter J. Mohler, Jeffrey N. Savas, Peter Penzes
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112784- (2023)
Summary: Rare genetic variants in ANK2, which encodes ankyrin-B, are associated with neurodevelopmental disorders (NDDs); however, their pathogenesis is poorly understood. We find that mice with prenatal deletion in cortical excitatory neurons and ol
Externí odkaz:
https://doaj.org/article/2e405b575a864345a6945ca6fb17a8ae
Autor:
Travis J. Kochan, Sophia H. Nozick, Rachel L. Medernach, Bettina H. Cheung, Samuel W. M. Gatesy, Marine Lebrun-Corbin, Sumitra D. Mitra, Natalia Khalatyan, Fiorella Krapp, Chao Qi, Egon A. Ozer, Alan R. Hauser
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-21 (2022)
Abstract Background Klebsiella pneumoniae strains have been divided into two major categories: classical K. pneumoniae, which are frequently multidrug-resistant and cause hospital-acquired infections in patients with impaired defenses, and hypervirul
Externí odkaz:
https://doaj.org/article/c05a5544bc954d2da3a46d61faa663f5
Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome
Autor:
Natalia Khalatyan, Jeffrey N. Savas, Leonardo E. Dionisio, Nicolas H. Piguel, Peter Penzes, Sehyoun Yoon
Publikováno v:
Molecular Psychiatry
Homer1 is a synaptic scaffold protein that regulates glutamatergic synapses and spine morphogenesis. HOMER1 knockout (KO) mice show behavioral abnormalities related to psychiatric disorders, and HOMER1 has been associated with psychiatric disorders s
Autor:
Roger S. Smith, Seesha R. Takagishi, David R. Amici, Kyle Metz, Sitaram Gayatri, Milad J. Alasady, Yaqi Wu, Sonia Brockway, Stephanie L. Taiberg, Natalia Khalatyan, Mikko Taipale, Sandro Santagata, Luke Whitesell, Susan Lindquist, Jeffrey N. Savas, Marc L. Mendillo
Publikováno v:
Science advances. 8(11)
Heat shock factor 1 (HSF1) is well known for its role in the heat shock response (HSR), where it drives a transcriptional program comprising heat shock protein (HSP) genes, and in tumorigenesis, where it drives a program comprising HSPs and many nonc
Autor:
Shimaa Soliman, Jeffrey N. Savas, Ali Shilatifard, Andrea Piunti, Marc A. Morgan, Ryan Rickels, Edwin R. Smith, Lu Wang, Emily J. Rendleman, Natalia Khalatyan, Marta Iwanaszko, Patrick A. Ozark
Publikováno v:
Genes Dev
Catalytic-inactivating mutations within the Drosophila enhancer H3K4 mono-methyltransferase Trr and its mammalian homologs, MLL3/4, cause only minor changes in gene expression compared with whole-gene deletions for these COMPASS members. To identify
Autor:
M Dolores, Martín-de-Saavedra, Marc, Dos Santos, Lorenza, Culotta, Olga, Varea, Benjamin P, Spielman, Euan, Parnell, Marc P, Forrest, Ruoqi, Gao, Sehyoun, Yoon, Emmarose, McCoig, Hiba A, Jalloul, Kristoffer, Myczek, Natalia, Khalatyan, Elizabeth A, Hall, Liam S, Turk, Antonio, Sanz-Clemente, Davide, Comoletti, Stefan F, Lichtenthaler, Jeffrey S, Burgdorf, Maria V, Barbolina, Jeffrey N, Savas, Peter, Penzes
Publikováno v:
Neuron
While many neuronal, membrane proteins undergo proteolytic cleavage, little is known about the biological significance of neuronal ectodomain shedding (ES). Here, we show that the neuronal sheddome is detectable in human cerebrospinal fluid (hCSF) an
Autor:
Emily J. Rendleman, Scott B. Rothbart, Robert M. Vaughan, Irina K. Popova, Michael-Christopher Keogh, Anup Vaidya, Sarah A. Howard, Zachary J. Dumar, Matthew J. Meiners, Ali Shilatifard, Marc A. Morgan, Rachel Watson, Jonathan M. Burg, Natalia Khalatyan, Matthew R. Marunde
Publikováno v:
Genesdevelopment. 35(23-24)
Mutations in thePHIP/BRWD2chromatin regulator cause the human neurodevelopmental disorder Chung-Jansen syndrome, while alterations inPHIPexpression are linked to cancer. Precisely how PHIP functions in these contexts is not fully understood. Here we
Publikováno v:
eNeuro
The striatum plays a key role in both reward-related and affective behaviors and disruptions to this circuit contributes to depression and drug addiction. However, our understanding of the molecular factors that facilitate and modify these processes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363317e93cacb3326b7e78dc210a39de
Autor:
Travis J. Kochan, Sophia H. Nozick, Rachel L. Medernach, Bettina H. Cheung, Samuel W.M. Gatesy, Marine Lebrun-Corbin, Sumitra D. Mitra, Natalia Khalatyan, Fiorella Krapp, Chao Qi, Egon A. Ozer, Alan R. Hauser
BackgroundKlebsiella pneumoniae (K. pneumoniae) strains have been divided into two major categories: classical K. pneumonia, which are frequently multidrug-resistant and cause hospital-acquired infections in patients with impaired defenses, and hyper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70b1f6a4a4ae232cfe44b54f69d32d84
https://doi.org/10.1101/2020.12.04.410209
https://doi.org/10.1101/2020.12.04.410209
Autor:
M. Dolores Martín-de-Saavedra, Marc Dos Santos, Lorenza Culotta, Olga Varea, Benjamin P. Spielman, Euan Parnell, Marc P. Forrest, Ruoqi Gao, Sehyoun Yoon, Emmarose McCoig, Hiba A. Jalloul, Kristoffer Myczek, Natalia Khalatyan, Elizabeth A. Hall, Liam S. Turk, Antonio Sanz-Clemente, Davide Comoletti, Stefan F. Lichtenthaler, Jeffrey S. Burgdorf, Maria V. Barbolina, Jeffrey N. Savas, Peter Penzes
Publikováno v:
Neuron 110(4), 627-643.e9 (2022). doi:10.1016/j.neuron.2021.11.025
Although many neuronal membrane proteins undergo proteolytic cleavage, little is known about the biological significance of neuronal ectodomain shedding (ES). Here, we show that the neuronal sheddome is detectable in human cerebrospinal fluid (hCSF)