Osthole Inhibits Expression of Genes Associated with Toll-like Receptor 2 Signaling Pathway in an Organotypic 3D Skin Model of Human Epidermis with Atopic Dermatitis

Autor: Natalia Karolina Kordulewska, Justyna Topa, Robert Stryiński, Beata Jarmołowska

Publikováno v: Cells, Vol 11, Iss 1, p 88 (2021)

The Toll-like receptor (TLR) family signature has been linked to the etiopathology of atopic dermatitis (AD), a chronic inflammatory skin disease associated with skin barrier dysfunction and immune system imbalance. We aimed to investigate whether os

Externí odkaz: https://doaj.org/article/b14e5425051f4d49989e57452404a1f9

TPH1 gene polymorphism rs211105 influences serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients

Autor: Konrad Wroński, Anna Cieślińska, Elżbieta Kostyra, Huub F. J. Savelkoul, Roman Grzybowski, Maria Latacz, Natalia Karolina Kordulewska, Dominika Rozmus, Janusz Płomiński, Jadwiga Snarska, Ewa Fiedorowicz

Background The role of serotonin and its metabolic pathway in proper functioning of the pancreas has not been thoroughly investigated yet in acute pancreatitis (AP) patients. Tryptophan hydroxylase (TPH) as the rate-limiting enzyme of serotonin synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21fe16ffae4f934c51f701f51bff96b6
https://doi.org/10.21203/rs.3.rs-567244/v2

Vitamin D Binding Protein (VDBP) and Its Gene Polymorphisms—The Risk of Malignant Tumors and Other Diseases

Autor: Alicja Ciesielska, Janusz Płomiński, Natalia Karolina Kordulewska, Roman Grzybowski, Anna Cieślińska, Dominika Rozmus, Huub F. J. Savelkoul, Ewa Fiedorowicz, Elżbieta Kostyra

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 7822, p 7822 (2020)
International Journal of Molecular Sciences, 21(21)
International Journal of Molecular Sciences 21 (2020) 21
International Journal of Molecular Sciences

Vitamin D is an important component of the endocrine system that controls calcium homeostasis and bone mineralization. Because of the very short half-life of free serum vitamin D it is stabilized and transported to target tissues by being bound to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc57b4ee2d73b51269e01b6020ecaa1
https://www.mdpi.com/1422-0067/21/21/7822

Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H1 receptor, COX-2, NF-κB, CCR1, chemokine CCL5/RANTES and interleukin-1β in PBMC allergic and non-allergic patients

Autor: Elżbieta Kostyra, Anna Cieślińska, Michał Matysiewicz, Edyta Sienkiewicz-Szłapka, Natalia Karolina Kordulewska, Ewa Fiedorowicz

Publikováno v: Immunobiology. 222:571-581

Introduction Fexofenadine (FXF) is a third-generation antihistamine drug and osthole is assumed as a natural antihistamine alternative. This paper compares results of histamine, FXF and osthole impact on HRH-1, COX-2, NF-κB-p50, CCR1 mRNA expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c77296c09ce7747c3a524dcc829dd5e
https://doi.org/10.1016/j.imbio.2016.11.004

Role of Milk-Derived Opioid Peptides and Proline Dipeptidyl Peptidase-4 in Autism Spectrum Disorders

Autor: Anna Cieślińska, Marta Bukało, Ewa Fiedorowicz, Małgorzata Moszyńska, Natalia Karolina Kordulewska, Elżbieta Kostyra, Aleksander Świątecki, Beata Jarmołowska

Publikováno v: Nutrients
Volume 11
Issue 1

Opioid peptides released during digestion of dietary proteins such as casein, were suggested to contribute to autism development, leading to the announcement of opioid excess hypothesis of autism. This paper examines role of enzyme proline dipeptidyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d6224a8aeb6e2f693bc9332314a0d8