Výsledky vyhledávání - "Natalia Girola"

Akademický článek

Molecular, Biological and Structural Features of VL CDR-1 Rb44 Peptide, Which Targets the Microtubule Network in Melanoma Cells

Autor: Natalia Girola, Pedro T. Resende-Lara, Carlos R. Figueiredo, Mariana H. Massaoka, Ricardo A. Azevedo, Rodrigo L. O. R. Cunha, Luciano Polonelli, Luiz R. Travassos

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

Microtubules are important drug targets in tumor cells, owing to their role in supporting and determining the cell shape, organelle movement and cell division. The complementarity-determining regions (CDRs) of immunoglobulins have been reported to be

Externí odkaz: https://doaj.org/article/127e3ac58e2645fbbcd2d8258bdd7894

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Akademický článek

Blockade of MIF–CD74 Signalling on Macrophages and Dendritic Cells Restores the Antitumour Immune Response Against Metastatic Melanoma

Autor: Carlos R. Figueiredo, Ricardo A. Azevedo, Sasha Mousdell, Pedro T. Resende-Lara, Lucy Ireland, Almudena Santos, Natalia Girola, Rodrigo L. O. R. Cunha, Michael C. Schmid, Luciano Polonelli, Luiz R. Travassos, Ainhoa Mielgo

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Mounting an effective immune response against cancer requires the activation of innate and adaptive immune cells. Metastatic melanoma is the most aggressive form of skin cancer. While immunotherapies have shown a remarkable success in melanoma treatm

Externí odkaz: https://doaj.org/article/2187804bb43e499384595d4ef3ffd93e

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Akademický článek

Antitumor Activity of Kielmeyera Coriacea Leaf Constituents in Experimental Melanoma, Tested in Vitro and in Vivo in Syngeneic Mice

Autor: Carlos Rogério Figueiredo, Alisson Leonardo Matsuo, Mariana Hiromi Massaoka, Natalia Girola, Ricardo Alexandre Azevedo, Aline Nogueira Rabaça, Camyla Fernandes Farias, Felipe Valença Pereira, Natalia Silva Matias, Luciana Pereira Silva, Elaine Guadelupe Rodrigues, João Henrique Guilardi Lago, Luiz Rodolpho Travassos, Regildo Márcio Gonçalves Silva

Publikováno v: Advanced Pharmaceutical Bulletin, Vol 4, Iss suppl 1, Pp 429-436 (2014)

Purpose: The antitumor activity of Kielmeyera coriacea (Clusiaceae), a medicinal plant used in the treatment of parasitic, as well as fungal and bacterial infections by the Brazilian Cerrado population, was investigated. Methods: A chloroform extrac

Externí odkaz: https://doaj.org/article/c35697c5444c4abcba33ebded4625025

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Akademický článek

A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno- and syngeneic systems

Autor: Mariana H. Massaoka, Alisson L. Matsuo, Carlos R. Figueiredo, Natalia Girola, Camyla F. Faria, Ricardo A. Azevedo, Luiz R. Travassos

Publikováno v: FEBS Open Bio, Vol 4, Iss C, Pp 153-161 (2014)

The Wilms tumor protein 1 (WT1) transcription factor has been associated in malignant melanoma with cell survival and metastasis, thus emerging as a candidate for targeted therapy. A lysine–arginine rich peptide, WT1-pTj, derived from the ZF domain

Externí odkaz: https://doaj.org/article/662503c711fb4c138eb788bb6790a70c

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Terpenoids from Leaves of Guarea macrophylla Display In Vitro Cytotoxic Activity and Induce Apoptosis In Melanoma Cells

Autor: João Henrique G. Lago, Natalia Girola, Guilherme Medeiros Antar, Patricia Sartorelli, Carlos R. Figueiredo, Marisi G. Soares, Sasha Mousdell, Geanne A. Alves Conserva, Ricardo A. Azevedo

Publikováno v: Planta medica

Guarea macrophylla is a Brazilian plant species that has been used in folk medicine to treat a range of diseases. Our ongoing work focuses on the discovery of new bioactive natural products derived from Brazilian flora. The current study describes th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a1eb7e9b2c1f0e6675abb5588c53ce
https://doi.org/10.1055/s-0043-107241

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AC‐1001 H3 CDR peptide induces apoptosis and signs of autophagy in vitro and exhibits antimetastatic activity in a syngeneic melanoma model

Autor: Pedro Ismael da Silva Junior, Mariana H. Massaoka, Aline Nogueira Rabaca, Camyla F. Farias, Renato A. Mortara, Carlos R. Figueiredo, Vera S. C. Maia, Fernando Real, Natalia Girola, Luiz R. Travassos, Dayane Batista Tada, Luciano Polonelli, Denise C. Arruda

Publikováno v: FEBS Open Bio
FEBS OPEN BIO

Antibody-derived peptides modulate functions of the immune system and are a source of anti-infective and antitumor substances. Recent studies have shown that they comprise amino acid sequences of immunoglobulin complementarity-determining regions, bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94310f0c129ef452793397645808cff1
http://europepmc.org/articles/PMC5011487

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Molecular, Biological and Structural Features of V

Autor: Natalia, Girola, Pedro T, Resende-Lara, Carlos R, Figueiredo, Mariana H, Massaoka, Ricardo A, Azevedo, Rodrigo L O R, Cunha, Luciano, Polonelli, Luiz R, Travassos

Publikováno v: Frontiers in Oncology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e8cbdd48c940a00a846afcfd2de3f1b
https://pubmed.ncbi.nlm.nih.gov/30740361

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Understanding the cytotoxic effects of new isovanillin derivatives through phospholipid Langmuir monolayers

Autor: Luciano Caseli, Ana Carolina de Carvalho, André C. Machado, Carlos R. Figueiredo, Natalia Girola, Thiago André Moura Veiga, Rafael C. Guadagnin, Lívia Soman de Medeiros

Publikováno v: Bioorganic chemistry. 83

Twenty-one isovanillin derivatives were prepared in order to evaluate their cytotoxic properties against the cancer cell lines B16F10-Nex2, HL-60, MCF-7, A2058 and HeLa. Among them, seven derivatives exhibited cytotoxic activity. We observed that for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bbc84737981c50d14806a3a9b2e280
https://pubmed.ncbi.nlm.nih.gov/30380449

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Interfering with MIF-CD74 signalling on macrophages and dendritic cells with a peptide-based approach restores the immune response against metastatic melanoma

Autor: Ainhoa Mielgo, Luiz R. Travassos, Sasha Mousdell, Ricardo A. Azevedo, Pedro T. Resende-Lara, Luciano Polonelli, Michael C. Schmid, Lucy Ireland, Carlos R. Figueiredo, Rodrigo L. O. R. Cunha, Almudena Santos, Natalia Girola

Mounting an effective immune response against cancer requires the activation of innate and adaptive immune cells. Metastatic melanoma is the most aggressive form of skin cancer. Immunotherapies that boost the activity of effector T cells have shown a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576c780b707bc2fa735f8699dcd20db0

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