Endocrinology and the brain: corticotropin-releasing hormone signaling

Autor: Carolina Inda, Natalia G Armando, Paula A dos Santos Claro, Susana Silberstein

Publikováno v: Endocrine Connections, Vol 6, Iss 6, Pp R99-R120 (2017)

Corticotropin-releasing hormone (CRH) is a key player of basal and stress-activated responses in the hypothalamic–pituitary–adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and be

Externí odkaz: https://doaj.org/article/f50434971a6f4ae78cf4fc2e376dd447

Bi-allelic variants in NAE1 cause intellectual disability, ischiopubic hypoplasia, stress-mediated lymphopenia and neurodegeneration

Autor: Irena J.J. Muffels, Imre F. Schene, Holger Rehmann, Maarten P.G. Massink, Maria M. van der Wal, Corinna Bauder, Martha Labeur, Natalia G. Armando, Maarten H. Lequin, Michiel L. Houben, Jaques C. Giltay, Saskia Haitjema, Albert Huisman, Fleur Vansenne, Judith Bluvstein, John Pappas, Lala V. Shailee, Yuri A. Zarate, Michal Mokry, Gijs W. van Haaften, Edward E.S. Nieuwenhuis, Damian Refojo, Femke van Wijk, Sabine A. Fuchs, Peter M. van Hasselt

Publikováno v: Am. J. Hum. Genet. 110, 146-160 (2023)
Am J Hum Genet

Neddylation has been implicated in various cellular pathways and in the pathophysiology of numerous diseases. We identified four individuals with bi-allelic variants in NAE1, which encodes the neddylation E1 enzyme. Pathogenicity was supported by dec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c527b80bc5f1809a16c16e4c32929181
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=67154

Endocrinology and the brain: corticotropin-releasing hormone signaling

Autor: Paula A dos Santos Claro, Natalia G Armando, Susana Silberstein, Carolina Inda

Publikováno v: Endocrine Connections
Endocrine Connections, Vol 6, Iss 6, Pp R99-R120 (2017)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Corticotropin-releasing hormone (CRH) is a key player of basal and stress activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d1b74e3969044c1649e3dbbec23505
https://doi.org/10.1530/ec-17-0111

A fluorescence nanoscopy marker for corticotropin-releasing hormone type 1 receptor: Computer design, synthesis, signaling effects, super-resolved fluorescence imaging, and: In situ affinity constant in cells

Autor: Fernando D. Stefani, Claudio N. Cavasotto, Alan M. Szalai, Natalia G. Armando, Sara E. Bari, Luciana Giordano, Susana Silberstein, Federico Martín Barabas, Pedro F Aramendía

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Class B G protein-coupled receptors (GPCRs) are involved in a variety of human pathophysiological states. These groups of membrane receptors are less studied than class A GPCRs due to the lack of structural information, delayed small molecule drug di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593a306c23b8e4383ecdff731cec665e
https://pubs.rsc.org/en/content/articlelanding/2018/CP/C8CP06196C