A phase III study to access the safety and efficacy of prolgolimab 250 mg fixed dose administered every 3 weeks versus prolgolimab 1 mg/kg every 2 weeks in patients with metastatic melanoma (FLAT)

Autor: Lev Demidov, Galina Kharkevich, Natalia Petenko, Vladimir Moiseenko, Svetlana Protsenko, Tatiana Semiglazova, Anastasia Zimina, Nadezhda Kovalenko, Natalia Fadeeva, Dmitry Kirtbaya, Igor Belogortsev, Denis Tantsyrev, Svetlana Odintsova, Alfia Nesterova, Karina Vorontsova, Yulia Makarycheva, Yulia Linkova, Arina Zinkina-Orikhan, Anna Siliutina, Irina Sorokina, Daria Liaptseva, Vladimir Chistyakov, Anton Lutsky

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

BackgroundProlgolimab is the first Russian PD-1 inhibitor approved for the first-line treatment of unresectable or metastatic melanoma and advanced non-small cell lung cancer. It was approved in two weight-based regimens of 1 mg/kg Q2W and 3 mg/kg Q3

Externí odkaz: https://doaj.org/article/f9e274f24e4c449f852c192658eb49c8

About the weathering effect on sedimentary rocks organic matter

Autor: Mikhail Delengov, Natalia Fadeeva, Maria Bolshakova, Elena Kozlova

Publikováno v: Georesursy. 24:36-46

To get properties and characteristics of oil and gas source rocks and for other geological aims, geologists analyzes core samples from wells and outcrop samples. But we should probably somehow correct geochemical source rock properties data we get on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcb131eceb3423b1a730fda6e914a49b
https://doi.org/10.18599/grs.2022.2.7

Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial

Autor: Kohei Shitara, Mustafa Özgüroğlu, Yung-Jue Bang, Maria Di Bartolomeo, Mario Mandalà, Min-Hee Ryu, Lorenzo Fornaro, Tomasz Olesiński, Christian Caglevic, Hyun C Chung, Kei Muro, Eray Goekkurt, Wasat Mansoor, Raymond S McDermott, Einat Shacham-Shmueli, Xinqun Chen, Carlos Mayo, S Peter Kang, Atsushi Ohtsu, Charles S Fuchs, Guillermo Lerzo, Juan Manuel O'Connor, Guillermo Ariel Mendez, James Lynam, Niall Tebbutt, Mark Wong, Andrew Strickland, Chris Karapetis, David Goldstein, Paul Vasey, Jean-Luc Van Laethem, Eric Van Cutsem, Scott Berry, Mark Vincent, Bettina Muller, Felipe Rey, Angela Zambrano, Joaquin Guerra, Merete Krogh, Lene Baeksgaard, Mette Yilmaz, Anneli Elme, Andrus Magi, Paivi Auvinen, Tuomo Alanko, Markus Moehler, Volker Kunzmann, Thomas Seufferlein, Peter Thuss-Patience, Thomas Hoehler, Georg Haag, Salah-Eddin Al-Batran, Hugo Castro, Karla Lopez, Mynor Aguilar Vasquez, Mario Sandoval, Ka On Lam, Sinead Cuffe, Cathy Kelly, Ravit Geva, Ayala Hubert, Alex Beny, Baruch Brenner, Aprile Giuseppe, Alfredo Falcone, Evaristo Maiello, Rodolfo Passalacqua, Vincenzo Montesarchio, Hiroki Hara, Keisho Chin, Tomohiro Nishina, Yoshito Komatsu, Nozumo Machida, Shuichi Hironaka, Taroh Satoh, Takao Tamura, Naotaoshi Sugimoto, Haruhiko Cho, Yashushi Omuro, Ken Kato, Masahiro Goto, Ichinosuke Hyodo, Kazuhiro Yoshida, Hideo Baba, Taito Esaki, Junji Furuse, Wan Zamaniah Wan Mohammed, Carlos Hernandez Hernandez, Juan Casas Garcia, Adriana Dominguez Andrade, Katriona Clarke, Geir Hjortland, Nils Glenjen, Tomasz Kubiatowski, Jassem Jacek, Marek Wojtukiewicz, Sergey Lazarev, Yuri Lancukhay, Sergey Afanasayev, Vladimir Moiseyenko, Vladimir Kostorov, Svetlana Protsenko, Vadim Shirinkin, Dina Sakaeva, Natalia Fadeeva, Wei Peng Yong, Chau Hsien Matthew Ng, Barbara Robertson, Bernardo Rapaport, Graham Cohen, Lydia Dreosti, Paul Ruff, Conrad Jacobs, Gregory Landers, Waldemar Szpak, Sang-Young Roh, Jeeyun Lee, Yeul Hong Kim, Hyun Cheol Chung, Maria Alsina Maqueda, Federico Longo Munoz, Andres Cervantes Aguilar, Enrique Aranda Aguilar, Pilar Garcia Alfonso, Fernando Rivera, Jaime Feliu Batle, Roberto Pazo Cid, Kun-Huei Yeh, Jen-Shi Chen, Yee Chao, Chia-Jui Yen, Oguz Kara, Suayib Yalcin, Daniel Hochhauser, Ian Chau, Al Benson, Veena Shankaran, Walid Shaib, Philip Philip, Vivek Sharma, Robert Siegel, Weijing Sun, Zev Wainberg, Ben George, Andrea Bullock, Samuel Myrick, Josephine Faruol, Richard Siegel, Timothy Larson, Carlos Becerra, Suresh Ratnam, Donald A. Richards, Stephen L. Riche

Publikováno v: The Lancet. 392:123-133

Summary Background Patients with advanced gastric or gastro-oesophageal junction cancer that progresses on chemotherapy have poor outcomes. We compared pembrolizumab with paclitaxel in patients with advanced gastric or gastro-oesophageal junction can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bba2ed478ffd93b7a80cdb96e7ab7b
https://doi.org/10.1016/s0140-6736(18)31257-1

Admirandus multicavus and Adoncholaimus ussuriensis sp. n. (Nematoda: Enoplida: Oncholaimidae) from the Sea of Japan

Autor: Natalia Fadeeva, Victoria Yagodina, Dmitry Atopkin, Julia Zograf, Vladimir V. Mordukhovich

Publikováno v: Nematology. 17:1229-1244

A description of one new, and redescription of one known, species of the subfamily Adoncholaiminae (Nematoda: Oncholaimidae) from Peter the Great Bay (Sea of Japan) are provided. Adoncholaimus ussuriensis sp. n. is characterised by relatively large b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0452090d1dd13ed123aa04cb0a400f5d
https://doi.org/10.1163/15685411-00002937

Phase II trial (BCD-100-2/MIRACULUM) of the novel PD-1 inhibitor (BCD-100) in patients with advanced melanoma

Autor: Aleksey Andreev, Svetlana V. Odintsova, Dina Sakaeva, Mariia Shustova, Natalia Fadeeva, Anna Tarasova, Tatiana Semiglazova, Ruslan Zukov, Lev V. Demidov, Roman Ivanov, Sergey Fogt, Olesya Gavrilova, Yuliya Makarova, Vladimir Moiseyenko, Marina Nechaeva, Svetlana Protsenko, Sergey Lazarev, Sergei Tjulandin

Publikováno v: Journal of Clinical Oncology. 37:9549-9549

9549 Background: MIRACULUM (NCT03269565) is a multicenter open-label parallel-arm phase II study investigating the antitumor activity of BCD-100, an IgG1 anti-PD-1 monoclonal antibody with Fc silencing “LALA” mutation, in patients with advanced m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ede6e7a56b3fd81e5edaeb39dca541c
https://doi.org/10.1200/jco.2019.37.15_suppl.9549