Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Natalia F. Krynetskaia"'
The identification of new molecular components of the DNA damage signaling cascade opens novel avenues to enhance the efficacy of chemotherapeutic drugs. High-mobility group protein 1 (HMGB1) is a DNA damage sensor responsive to the incorporation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a27133b321d34e0af16e2a563f510ce
https://doi.org/10.1158/1535-7163.c.6531837
https://doi.org/10.1158/1535-7163.c.6531837
Supplementary Fig. S3 from Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b26d4bbd64a32c0c46815f7b1a5a542
https://doi.org/10.1158/1535-7163.22485225
https://doi.org/10.1158/1535-7163.22485225
Supplementary Fig. S2 from Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ae954d34e9c30d0d273c0d93a6ad85
https://doi.org/10.1158/1535-7163.22485228.v1
https://doi.org/10.1158/1535-7163.22485228.v1
Supplementary Table from Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a485e543e2e66e277f23684e6bd4754
https://doi.org/10.1158/1535-7163.22485216
https://doi.org/10.1158/1535-7163.22485216
Publikováno v:
Anti-Cancer Drugs. 24:366-374
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays a central role in glycolysis. Because cancer cells rely on aerobic glycolysis rather than oxidative phosphorylation, GAPDH-depleting agents have a therapeutic potential to impede cancer cell prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d80f5bc231101ea3de119f21b1728de
https://doi.org/10.1097/cad.0b013e32835e3378
https://doi.org/10.1097/cad.0b013e32835e3378
Autor:
Yiping Fan, William E. Evans, Meyling Cheok, Cheng Cheng, Wenjian Yang, Peggy Hsieh, Mary V. Relling, Deqing Pei, Barthelemy Diouf, Hui Geng, Charles G. Mullighan, Siying Chen, Qing Cheng, William E. Thierfelder, Natalia F. Krynetskaia, Ching-Hon Pui, James R. Downing, Evgeny Y. Krynetskiy
Publikováno v:
Nature medicine
DNA mismatch repair enzymes (for example, MSH2) maintain genomic integrity, and their deficiency predisposes to several human cancers and to drug resistance. We found that leukemia cells from a substantial proportion of children (∼11%) with newly d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fba2ae7f9e4f4b947486b2107794bf
https://doi.org/10.1038/nm.2430
https://doi.org/10.1038/nm.2430
Autor:
Eugene Y. Krynetski, Elena Samochatova, William E. Evans, Natalia V. Chupova, Anastassia Rudneva, Olga A. Maiorova, Tatyana V. Nasedkina, Raul C. Ribeiro, Olga Makarova, O. E. Fedorova, Natalia F. Krynetskaia, Alexander G. Roumyantsev, Andrei S. Glotov, Zh. M. Kozhekbaeva
Publikováno v:
Pediatric Blood & Cancer. 52:203-208
Background Polymorphisms that reduce the activity of thiopurine S-methyltransferase (TPMT) cause adverse reactions to conventional doses of thiopurines, routinely used for antileukemic and immunosuppressive treatment. There are more than 20 variant a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::783889740afc898c1fad5af311de955b
https://doi.org/10.1002/pbc.21837
https://doi.org/10.1002/pbc.21837
Autor:
O. E. Fedorova, Raul C. Ribeiro, Elena Samochatova, Andrei S. Glotov, Victor Barsky, Natalia F. Krynetskaia, Janna M Kozhekbaeva, Olga A. Maiorova, Alexander V. Chudinov, Cheng Cheng, Anastasia E. Roudneva, Natalia V. Chupova, Tatyana V. Nasedkina, Valeria V Zemlyakova, Eugene Y Krynetskiy, Alexander G. Roumyantsev, Roman A Yurasov, William E. Evans, Alexander S. Zasedatelev
Publikováno v:
European Journal of Human Genetics. 14:991-998
Thiopurine drugs are metabolized, in part, by S-methylation catalyzed by thiopurine S-methyltransferase (TPMT). Patients with very low or undetectable TPMT activity are at high risk of severe, potentially fatal hematopoietic toxicity when they are tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cee3a73eccbf5fa9189c8a81f98877
https://doi.org/10.1038/sj.ejhg.5201647
https://doi.org/10.1038/sj.ejhg.5201647
Autor:
John C. Panetta, Timothy L. Brenner, Natalia F. Krynetskaia, Eugene Y. Krynetski, William E. Evans, Pui Ching-Hon, Weinan Du
Publikováno v:
Molecular Pharmacology. 64:456-465
The amount of MSH2 protein, a major component of the mismatch repair system, was found to differ >10-fold in leukemia cells from children with newly diagnosed acute lymphoblastic leukemia, with a subgroup of patients (17%) having undetectable MSH2 pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8054673608eb5602d5297e28aa6f4cdd
https://doi.org/10.1124/mol.64.2.456
https://doi.org/10.1124/mol.64.2.456
Autor:
Eugene Y. Krynetski, Richard D. Beger, Richard W. Kriwacki, Natalia F. Krynetskaia, William E. Evans, Craig A. Marhefka, Weixing Zhang, Lilla Somerville
Publikováno v:
Journal of Biological Chemistry. 278:1005-1011
Mercaptopurine and thioguanine, two of the most widely used antileukemic agents, exert their cytotoxic, therapeutic effects by being incorporated into DNA as deoxy-6-thioguanosine. However, the molecular mechanism(s) by which incorporation of these t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acbd17371d0bc11247aa877e70c4d88f
https://doi.org/10.1074/jbc.m204243200
https://doi.org/10.1074/jbc.m204243200