Interlaboratory proficiency processing scheme in CSF aliquoting: implementation and assessment based on biomarkers of Alzheimer’s disease

Autor: Piotr Lewczuk, Amélie Gaignaux, Olga Kofanova, Natalia Ermann, Fay Betsou, Sebastian Brandner, Barbara Mroczko, Kaj Blennow, Dominik Strapagiel, Silvia Paciotti, Jonathan Vogelgsang, Michael H. Roehrl, Sandra Mendoza, Johannes Kornhuber, Charlotte Teunissen

Publikováno v: Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-9 (2018)

Abstract Background In this study, we tested to which extent possible between-center differences in standardized operating procedures (SOPs) for biobanking of cerebrospinal fluid (CSF) samples influence the homogeneity of the resulting aliquots and,

Externí odkaz: https://doaj.org/article/06a4c8af5f0a46baa4f8f0d1d8d230d4

A Specific Reduction in Aβ1−42 vs. a Universal Loss of Aβ Peptides in CSF Differentiates Alzheimer's Disease From Meningitis and Multiple Sclerosis

Autor: Philipp Spitzer, Roland Lang, Timo J. Oberstein, Piotr Lewczuk, Natalia Ermann, Hagen B. Huttner, Ilias Masouris, Johannes Kornhuber, Uwe Ködel, Juan M. Maler

Publikováno v: Frontiers in Aging Neuroscience, Vol 10 (2018)

A reduced concentration of Aβ1−42 in CSF is one of the established biomarkers of Alzheimer's disease. Reduced CSF concentrations of Aβ1−42 have also been shown in multiple sclerosis, viral encephalitis and bacterial meningitis. As neuroinflamma

Externí odkaz: https://doaj.org/article/e171ea72a63647559dd777a9a9272aed

CSF nonphosphorylated Tau as a biomarker for the discrimination of AD from CJD

Autor: Matthias Schmitz, Johannes Kornhuber, Piotr Lewczuk, Stefan Goebel, Peter Lange, Natalia Ermann, Franc Llorens, Inga Zerr, Tobias Knipper

Publikováno v: Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology 5(7), 883-887 (2018). doi:10.1002/acn3.584

Creutzfeldt–Jakob disease and Alzheimer's disease are characterized by the presence of elevated total‐Tau cerebrospinal fluid concentrations while the presence of hyperphosphorylated Tau forms in the cerebrospinal fluid is rather a hallmark of Al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424373dd598dfa75a49d500ab7c1bade
https://doi.org/10.1002/acn3.584

Interlaboratory proficiency processing scheme in CSF aliquoting: implementation and assessment based on biomarkers of Alzheimer’s disease

Autor: Sebastian Brandner, Fay Betsou, Johannes Kornhuber, Sandra Mendoza, Olga Kofanova, Kaj Blennow, Silvia Paciotti, Michael H.A. Roehrl, Piotr Lewczuk, Barbara Mroczko, Dominik Strapagiel, Natalia Ermann, Jonathan Vogelgsang, Amélie Gaignaux, Charlotte E. Teunissen

Publikováno v: Alzheimer's Research and Therapy, 10(1):87. BioMed Central
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-9 (2018)
Alzheimer's Research & Therapy
Lewczuk, P, Gaignaux, A, Kofanova, O, Ermann, N, Betsou, F, Brandner, S, Mroczko, B, Blennow, K, Strapagiel, D, Paciotti, S, Vogelgsang, J, Roehrl, M H, Mendoza, S, Kornhuber, J & Teunissen, C 2018, ' Interlaboratory proficiency processing scheme in CSF aliquoting: Implementation and assessment based on biomarkers of Alzheimer's disease ', Alzheimer's Research and Therapy, vol. 10, no. 1, 87 . https://doi.org/10.1186/s13195-018-0418-3

Background In this study, we tested to which extent possible between-center differences in standardized operating procedures (SOPs) for biobanking of cerebrospinal fluid (CSF) samples influence the homogeneity of the resulting aliquots and, consequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c91554b90a3761da61e460932364deb
http://resolver.sub.uni-goettingen.de/purl?gs-1/15311