Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors

Autor: Rogier Versteeg, Johan van Nes, Linda J. Valentijn, Jan Koster, Tim van Groningen, Igor Adameyko, Carel J.M. van Noesel, Richard Volckmann, Danny Zwijnenburg, Peter van Sluis, Alvin Chan, Franciska Haneveld, Nurdan Akogul, Boris Bleijlevens, Nancy E. Hasselt, Jennemiek van Arkel, Arjan Lakeman, Natalia E. Nowakowska, Peter Stroeken, Mohamed Hamdi, Ellen M. Westerhout

Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f14876aaaa2f25f4335b62b0c96a3c
https://doi.org/10.1158/0008-5472.22430725.v1

Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors

Autor: Linda J. Valentijn, Ellen M. Westerhout, Rogier Versteeg, Alvin Chan, Arjan Lakeman, Peter van Sluis, Natalia E Nowakowska, Mohamed Hamdi, Igor Adameyko, Nancy E. Hasselt, Boris Bleijlevens, Tim van Groningen, Franciska Haneveld, Jan Koster, Carel J. M. van Noesel, Nurdan Akogul, Richard Volckmann, Peter Stroeken, Danny A. Zwijnenburg, Jennemiek van Arkel, Johan van Nes

Publikováno v: Cancer research, 82(3), 484-496. American Association for Cancer Research Inc.

Cancer therapy frequently fails due to the emergence of resistance. Many tumors include phenotypically immature tumor cells, which have been implicated in therapy resistance. Neuroblastoma cells can adopt a lineage-committed adrenergic (ADRN) or an i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8eca38a6b36d94471b13429c50ac12
http://www.scopus.com/inward/record.url?scp=85124056607&partnerID=8YFLogxK

Neuroblastoma is composed of two super-enhancer-associated differentiation states

Autor: Bart A. Westerman, Rogier Versteeg, Arjan Lakeman, Johannes Bras, Peter van Sluis, Aldo Jongejan, Frank Baas, Antoine H. C. van Kampen, Jan J. Molenaar, Linda Koster, Margriet Huizer-Smit, Carel J. M. van Noesel, Nancy E. Hasselt, Danny A. Zwijnenburg, Lianne van Dijk-Kerkhoven, Marloes Broekmans, Mohamed Hamdi, Richard Volckmann, Tim van Groningen, Godelieve A.M. Tytgat, Franciska Haneveld, Natalia E Nowakowska, Linda J. Valentijn, Jan Koster, Nurdan Akogul, Piet Molenaar, Maria C. Lecca, Ellen M. Westerhout, Alvin Chan, Johan van Nes, Marli E. Ebus

Publikováno v: Nature Genetics, 49(8), 1261
Nature Genetics, 49(8), 1261-1266. Nature Publishing Group
Van Groningen, T, Koster, J, Valentijn, L J, Zwijnenburg, D A, Akogul, N, Hasselt, N E, Broekmans, M, Haneveld, F, Nowakowska, N E, Bras, J, Van Noesel, C J M, Jongejan, A, Van Kampen, A H, Koster, L, Baas, F, Van Dijk-Kerkhoven, L, Huizer-Smit, M, Lecca, M C, Chan, A, Lakeman, A, Molenaar, P, Volckmann, R, Westerhout, E M, Hamdi, M, Van Sluis, P G, Ebus, M E, Molenaar, J J, Tytgat, G A, Westerman, B A, Van Nes, J & Versteeg, R 2017, ' Neuroblastoma is composed of two super-enhancer-associated differentiation states ', Nature Genetics, vol. 49, no. 8, pp. 1261-1266 . https://doi.org/10.1038/ng.3899
Nature genetics, 49(8), 1261-1266. Nature Publishing Group

Neuroblastoma and other pediatric tumors show a paucity of gene mutations, which has sparked an interest in their epigenetic regulation. Several tumor types include phenotypically divergent cells, resembling cells from different lineage development s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f05e663859e4d514b96ffa508717332
https://doi.org/10.1038/ng.3899