Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

Autor: Fred D Mast, Peter C Fridy, Natalia E Ketaren, Junjie Wang, Erica Y Jacobs, Jean Paul Olivier, Tanmoy Sanyal, Kelly R Molloy, Fabian Schmidt, Magdalena Rutkowska, Yiska Weisblum, Lucille M Rich, Elizabeth R Vanderwall, Nicholas Dambrauskas, Vladimir Vigdorovich, Sarah Keegan, Jacob B Jiler, Milana E Stein, Paul Dominic B Olinares, Louis Herlands, Theodora Hatziioannou, D Noah Sather, Jason S Debley, David Fenyö, Andrej Sali, Paul D Bieniasz, John D Aitchison, Brian T Chait, Michael P Rout

Publikováno v: eLife, Vol 10 (2021)

The emergence of SARS-CoV-2 variants threatens current vaccines and therapeutic antibodies and urgently demands powerful new therapeutics that can resist viral escape. We therefore generated a large nanobody repertoire to saturate the distinct and hi

Externí odkaz: https://doaj.org/article/81f21ae91fa645928a68302720f1052b

From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae.

Autor: Con Dogovski, Michael A Gorman, Natalia E Ketaren, Judy Praszkier, Leanne M Zammit, Haydyn D Mertens, Gary Bryant, Ji Yang, Michael D W Griffin, F Grant Pearce, Juliet A Gerrard, Geoffrey B Jameson, Michael W Parker, Roy M Robins-Browne, Matthew A Perugini

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e83419 (2013)

Given the rise in drug-resistant Streptococcus pneumoniae, there is an urgent need to discover new antimicrobials targeting this pathogen and an equally urgent need to characterize new drug targets. A promising antibiotic target is dihydrodipicolinat

Externí odkaz: https://doaj.org/article/576bb07699574f23beff6f14ff20f259

Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

Autor: Jean Paul Olivier, Erica Y Jacobs, Junjie Wang, Natalia E Ketaren, Peter C Fridy, Fred D Mast, Tanmoy Sanyal, Kelly R Molloy, Fabian Schmidt, Magdalena Rutkowska, Yiska Weisblum, Lucille M Rich, Elizabeth R Vanderwall, Nicholas Dambrauskas, Vladimir Vigdorovich, Sarah Keegan, Jacob B Jiler, Milana E Stein, Paul Dominic B Olinares, Louis Herlands, Theodora Hatziioannou, D Noah Sather, Jason S Debley, David Fenyö, Andrej Sali, Paul D Bieniasz, John D Aitchison, Brian T Chait, Michael P Rout

Publikováno v: bioRxiv
article-version (status) pre
article-version (number) 1
eLife, Vol 10 (2021)

SUMMARY Despite the great promise of vaccines, the COVID-19 pandemic is ongoing and future serious outbreaks are highly likely, so that multi-pronged containment strategies will be required for many years. Nanobodies are the smallest naturally occurr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256e222ad1c80762e3e30acaf14d6531
https://doi.org/10.7554/elife.73027

Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2

Autor: Brian T. Chait, Kelly R. Molloy, Fabian Schmidt, Erica Y. Jacobs, L.M. Rich, Fred D. Mast, Sarah Keegan, Magdalena Rutkowska, Olinares Pdb, Jiler Jb, Jiayi Wang, Michael P. Rout, Paul D. Bieniasz, Andrej Sali, Jason S. Debley, Jean Paul Olivier, Tanmoy Sanyal, Stein Me, Yiska Weisblum, Natalia E. Ketaren, Vigdorovich, E. R. Vanderwall, Nicholas Dambrauskas, David Fenyö, D. N. Sather, Peter C. Fridy, Theodora Hatziioannou, John D. Aitchison

Publikováno v: eLife

SUMMARYDespite the great promise of vaccines, the COVID-19 pandemic is ongoing and future serious outbreaks are highly likely, so that multi-pronged containment strategies will be required for many years. Nanobodies are the smallest naturally occurri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4659b3535ad23310db59271ee7fd618a
https://doi.org/10.1101/2021.04.08.438911

Purification and analysis of endogenous human RNA exosome complexes

Autor: Kelly R. Molloy, Michal Domanski, Torben Heick Jensen, John LaCava, William J. Rice, Natalia E. Ketaren, Michael P. Rout, David L. Stokes, Paula Upla

Publikováno v: Domanski, M, Upla, P, Rice, W J, Molloy, K R, Ketaren, N E, Stokes, D L, Jensen, T H, Rout, M P & Lacava, J 2016, ' Purification and analysis of endogenous human RNA exosome complexes ', RNA, vol. 22, no. 9, pp. 1467-1475 . https://doi.org/10.1261/rna.057760.116

As a result of its importance in key RNA metabolic processes, the ribonucleolytic RNA exosome complex has been the focus of intense study for almost two decades. Research on exosome subunit assembly, cofactor and substrate interaction, enzymatic cata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a00e46a45bfcc94d2db82cffde76241
https://doi.org/10.1261/rna.057760.116