Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Natalia Delis"'
Autor:
Vida Vafaizadeh, Bernd Groner, Boris Brill, Natalia Delis, Richard Moriggl, Corina Borghouts, Christian Brendel, Axel Weber
Publikováno v:
Pharmaceuticals, Vol 6, Iss 8, Pp 960-987 (2013)
The signal transducer and activator of transcription Stat5 is transiently activated by growth factor and cytokine signals in normal cells, but its persistent activation has been observed in a wide range of human tumors. Aberrant Stat5 activity was in
Externí odkaz:
https://doaj.org/article/90b771fd216f485f8c85940a24bd80e8
Autor:
Natalia Delis, Corina Borghouts, Christian Brendel, Richard Moriggl, Bernd Groner, Vida Vafaizadeh, Boris Brill, Axel Weber
Publikováno v:
Cancers, Vol 7, Iss 1, Pp 503-537 (2015)
Cancers
Volume 7
Issue 1
Pages 503-537
Cancers
Volume 7
Issue 1
Pages 503-537
Signal transducers and activators of transcription (Stats) play central roles in the conversion of extracellular signals, e.g., cytokines, hormones and growth factors, into tissue and cell type specific gene expression patterns. In normal cells, thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae402e0f620ff86992ca206e00b3fe1
http://www.mdpi.com/2072-6694/7/1/503
http://www.mdpi.com/2072-6694/7/1/503
Publikováno v:
Analytical Biochemistry. 466:83-88
The presence of endotoxins in preparations of recombinantly produced therapeutic proteins poses serious problems for patients. Endotoxins can cause fever, respiratory distress syndromes, intravascular coagulation, or endotoxic shock. A number of meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37ae801bc4ef7d94039a9d8419c24a7
https://doi.org/10.1016/j.ab.2014.08.020
https://doi.org/10.1016/j.ab.2014.08.020
Autor:
Diane Richter, Chul Min Yang, Viktoria von Manstein, Vida Vafaizadeh, Bernd Groner, Natalia Delis
Publikováno v:
Current Signal Transduction Therapy
Scopus-Elsevier
Scopus-Elsevier
The emergence of low molecular weight kinase inhibitors as "targeted" drugs has led to remarkable advances in the treatment of cancer patients. The clinical benefits of these tumor therapies, however, vary widely in patient populations and with durat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8d98e43502b25c814da3181b82b810
https://doi.org/10.2174/1574362409666140206221931
https://doi.org/10.2174/1574362409666140206221931
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 138:1205-1220
Background Proteins involved in the aberrant regulation of signaling pathways and their downstream effectors are promising targets for cancer therapy. Survivin is an antiapoptotic and cell cycle-promoting protein, which is consistently overexpressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa613586e1e5f03a000977959a04ca8
https://doi.org/10.1007/s00432-012-1195-1
https://doi.org/10.1007/s00432-012-1195-1
Autor:
Boris Brill, Laura Mack, Corina Borghouts, Natalia Delis, Peter Lucks, Astrid Weiss, Bernd Groner
Publikováno v:
JAK-STAT
Cancer cells are characterized by the aberrant activation of signaling pathways governing proliferation, survival, angiogenesis, migration and immune evasion. These processes are partially regulated by the transcription factor STAT3. This factor is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc46c9343fe867cd4312ba84db77dea
https://doi.org/10.4161/jkst.18947
https://doi.org/10.4161/jkst.18947
Autor:
Corina Borghouts, Bernd Groner, Boris Brill, Hannah Schöneberger, Astrid Weiss, Natalia Delis
Publikováno v:
Hormone Molecular Biology and Clinical Investigation. 5:1-9
We are characterizing peptides which are able to interact with functional domains of oncoproteins and thus inhibit their activity. The yeast two-hybrid system was used to derive a peptide sequence which specifically interacts with the dimerization do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb423e307bab67250d1705ca62b3d88
https://doi.org/10.1515/hmbci.2011.013
https://doi.org/10.1515/hmbci.2011.013
Publikováno v:
Molecular Cancer Research. 6:267-281
Signal transduction events often involve the assembly of protein complexes dependent on modular interactions. The inappropriate assembly of modular components plays a role in oncogenic transformation and can be exploited for therapeutic purposes. Sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d32d152c068ea3f1b731d27e0773416
https://doi.org/10.1158/1541-7786.mcr-07-0245
https://doi.org/10.1158/1541-7786.mcr-07-0245
Autor:
Tomohiro Chiba, Boris Brill, Viktoria von Manstein, Vida Vafaizadeh, Thomas Oellerich, Natalia Delis, Bernd Groner, Chul Min Yang
Publikováno v:
International Journal of Cancer
Cellular transformation is initiated by the activation of oncogenes and a closely associated developmental reprogramming of the epigenetic landscape. Transcription factors, regulators of chromatin states and microRNAs influence cell fates in developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9b110e500168d61d0b422e2d6ed2a4
https://pubmed.ncbi.nlm.nih.gov/25991553
https://pubmed.ncbi.nlm.nih.gov/25991553
Autor:
Corina Borghouts, Bernd Groner, Boris Brill, Christian Brendel, Vida Vafaizadeh, Axel Weber, Natalia Delis, Richard Moriggl
Publikováno v:
Pharmaceuticals
Volume 6
Issue 8
Pages 960-987
Pharmaceuticals, Vol 6, Iss 8, Pp 960-987 (2013)
Volume 6
Issue 8
Pages 960-987
Pharmaceuticals, Vol 6, Iss 8, Pp 960-987 (2013)
The signal transducer and activator of transcription Stat5 is transiently activated by growth factor and cytokine signals in normal cells, but its persistent activation has been observed in a wide range of human tumors. Aberrant Stat5 activity was in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8436269d0a23d18a5b79570c4bb4a78a