Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Natalia De Val"'
Autor:
Nan Li, Alex Quan, Dan Li, Jiajia Pan, Hua Ren, Gerard Hoeltzel, Natalia de Val, Dana Ashworth, Weiming Ni, Jing Zhou, Sean Mackay, Stephen M. Hewitt, Raul Cachau, Mitchell Ho
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Glypican-1 (GPC1) expression is elevated in pancreatic cancer and has been exploited as a therapeutic target. Here the authors report the development of VHH nanobody-based CAR-T cells targeting GPC1, showing anti-tumor activity in pancreatic cancer p
Externí odkaz:
https://doaj.org/article/a61d87f106544eda8b190f53207ab475
Autor:
Holly Y Chen, Manju Swaroop, Samantha Papal, Anupam K Mondal, Hyun Beom Song, Laura Campello, Gregory J Tawa, Florian Regent, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Samuel G Jacobson, Wei Zheng, Anand Swaroop
Publikováno v:
eLife, Vol 12 (2023)
Ciliopathies manifest from sensory abnormalities to syndromic disorders with multi-organ pathologies, with retinal degeneration a highly penetrant phenotype. Photoreceptor cell death is a major cause of incurable blindness in retinal ciliopathies. To
Externí odkaz:
https://doaj.org/article/d7b516710de643d58647394ef7678b1a
Autor:
Nan Gao, Yanxin Gai, Lina Meng, Chu Wang, Wei Wang, Xiaojun Li, Tiejun Gu, Mark K. Louder, Nicole A. Doria‐Rose, Kevin Wiehe, Alexandra F. Nazzari, Adam S. Olia, Jason Gorman, Reda Rawi, Wenmin Wu, Clayton Smith, Htet Khant, Natalia de Val, Bin Yu, Junhong Luo, Haitao Niu, Yaroslav Tsybovsky, Huaxin Liao, Thomas B. Kepler, Peter D. Kwong, John R. Mascola, Chuan Qin, Tongqing Zhou, Xianghui Yu, Feng Gao
Publikováno v:
Advanced Science, Vol 9, Iss 15, Pp n/a-n/a (2022)
Abstract Understanding maturation pathways of broadly neutralizing antibodies (bnAbs) against HIV‐1 can be highly informative for HIV‐1 vaccine development. A lineage of J038 bnAbs is now obtained from a long‐term SHIV‐infected macaque. J038
Externí odkaz:
https://doaj.org/article/bb2780d69c034667a7617667bf5974ca
Autor:
Adrian Lita, Artem Pliss, Andrey Kuzmin, Tomohiro Yamasaki, Lumin Zhang, Tyrone Dowdy, Christina Burks, Natalia de Val, Orieta Celiku, Victor Ruiz-Rodado, Elena-Raluca Nicoli, Michael Kruhlak, Thorkell Andresson, Sudipto Das, Chunzhang Yang, Rebecca Schmitt, Christel Herold-Mende, Mark R. Gilbert, Paras N. Prasad, Mioara Larion
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The understanding of altered lipid metabolism by isocitrate dehydrogenase 1 (IDH1) mutations in gliomas at a compartment-specific level is limited. Here, the authors use Raman spectroscopy to monitor organelle-specific metabolic changes and report th
Externí odkaz:
https://doaj.org/article/1908125b7bca48998003ff46dab75493
Autor:
Giuseppe Cimicata, Gil Fridkin, Tanaya Bose, Zohar Eyal, Yehuda Halfon, Elinor Breiner-Goldstein, Tara Fox, Ella Zimmerman, Anat Bashan, Natalia de Val, Alexander Wlodawer, Ada Yonath
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT The ribosome, a multicomponent assembly consisting of RNA and proteins, is a pivotal macromolecular machine that translates the genetic code into proteins. The large ribosomal subunit rRNA helix 68 (H68) is a key element in the protein synth
Externí odkaz:
https://doaj.org/article/d0fed25417f0439887632ec8537d4997
Autor:
Matthew J. Brooks, Holly Y. Chen, Ryan A. Kelley, Anupam K. Mondal, Kunio Nagashima, Natalia De Val, Tiansen Li, Vijender Chaitankar, Anand Swaroop
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 891-905 (2019)
Summary: Stem cell-derived retinal organoids recapitulate many landmarks of in vivo differentiation but lack functional maturation of distinct cell types, especially photoreceptors. Using comprehensive temporal transcriptome analyses, we show that tr
Externí odkaz:
https://doaj.org/article/55d75f04bc144eb088aab1172e9f26fa
Autor:
Istvan Botos, George T. Lountos, Weimin Wu, Scott Cherry, Rodolfo Ghirlando, Arsen M. Kudzhaev, Tatyana V. Rotanova, Natalia de Val, Joseph E. Tropea, Alla Gustchina, Alexander Wlodawer
Publikováno v:
Current Research in Structural Biology, Vol 1, Iss , Pp 13-20 (2019)
Energy-dependent Lon proteases play a key role in cellular regulation by degrading short-lived regulatory proteins and misfolded proteins in the cell. The structure of the catalytically inactive S679A mutant of Escherichia coli LonA protease (EcLon)
Externí odkaz:
https://doaj.org/article/3a4bafe2973a426e8039983c811a2c88
Autor:
Yuan Liu, Adrian Lankenau Ahumada, Emine Bayraktar, Paul Schwartz, Mamur Chowdhury, Sixiang Shi, Manu M. Sebastian, Htet Khant, Natalia de Val, Nazende Nur Bayram, Guodong Zhang, Thanh Chung Vu, Zuliang Jie, Nicholas B. Jennings, Cristian Rodriguez-Aguayo, Jody Swain, Elaine Stur, Lingegowda S. Mangala, Yutuan Wu, Supriya Nagaraju, Brooke Ermias, Chun Li, Gabriel Lopez-Berestein, Janet Braam, Anil K. Sood
Publikováno v:
Journal of Controlled Release. 357:472-483
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a8e2b2b122da5197462cc855b0056ea
https://doi.org/10.1016/j.jconrel.2023.03.056
https://doi.org/10.1016/j.jconrel.2023.03.056
Autor:
Nan Li, Madeline B. Torres, Madeline R. Spetz, Ruixue Wang, Luyi Peng, Meijie Tian, Christopher M. Dower, Rosa Nguyen, Ming Sun, Chin-Hsien Tai, Natalia de Val, Raul Cachau, Xiaolin Wu, Stephen M. Hewitt, Rosandra N. Kaplan, Javed Khan, Brad St Croix, Carol J. Thiele, Mitchell Ho
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 6, Pp 100297- (2021)
Summary: Targeting solid tumors must overcome several major obstacles, in particular, the identification of elusive tumor-specific antigens. Here, we devise a strategy to help identify tumor-specific epitopes. Glypican 2 (GPC2) is overexpressed in ne
Externí odkaz:
https://doaj.org/article/1562370b31514de19b560ba348a2c0f6
Autor:
Fangping Cai, Wei-Hung Chen, Weimin Wu, Julia A Jones, Misook Choe, Neelakshi Gohain, Xiaoying Shen, Celia LaBranche, Amanda Eaton, Laura Sutherland, Esther M Lee, Giovanna E Hernandez, Nelson R Wu, Richard Scearce, Michael S Seaman, M Anthony Moody, Sampa Santra, Kevin Wiehe, Georgia D Tomaras, Kshitij Wagh, Bette Korber, Mattia Bonsignori, David C Montefiori, Barton F Haynes, Natalia de Val, M Gordon Joyce, Kevin O Saunders
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009624 (2021)
A primary goal of HIV-1 vaccine development is the consistent elicitation of protective, neutralizing antibodies. While highly similar neutralizing antibodies (nAbs) have been isolated from multiple HIV-infected individuals, it is unclear whether vac
Externí odkaz:
https://doaj.org/article/49af7daf7eef4bd3a19720f1036c1e68