Polyurethane–polyurea hybrid nanocapsules as efficient delivery systems of anticancer Ir(iii) metallodrugs

Autor: Joaquín Bonelli, Enrique Ortega-Forte, Gloria Vigueras, Manel Bosch, Natalia Cutillas, Josep Rocas, José Ruiz, Vicente Marchán

Publikováno v: Inorganic Chemistry Frontiers. 9:2123-2138

Cyclometalated Ir(III) complexes hold great promise as an alternative to platinum metallodrugs for the therapy and diagnosis of cancer. However, their low aqueous solubility and poor cell membrane permeability are obstacles for in vivo applications.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46685c8cb0dec0a2672802fea64173cf
https://doi.org/10.1039/d1qi01542g

A photoactivated Ir(iii) complex targets cancer stem cells and induces secretion of damage-associated molecular patterns in melanoma cells characteristic of immunogenic cell death

Autor: Viktor Brabec, Natalia Cutillas, Hana Kostrhunova, Jana Kasparkova, Vojtech Novohradsky, José Ruiz, Gloria Vigueras, Alicia Marco, Lenka Markova

Publikováno v: Inorganic Chemistry Frontiers. 8:4696-4711

Several anticancer chemotherapies, while eliminating the bulk of tumor cells, often fail, as they do not obliterate a small fraction of malignant cancer stem cells (CSCs). Thus, developing chemotherapeutics capable of targeting and abrogating CSCs, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17f531af03fa8dd14a50f430907452d8
https://doi.org/10.1039/d1qi00856k

Exploring the Effect of Polypyridyl Ligands on the Anticancer Activity of Phosphorescent Iridium(III) Complexes: From Proteosynthesis Inhibitors to Photodynamic Therapy Agents

Autor: Jitka Pracharova, Gloria Vigueras, Jana Kasparkova, Natalia Cutillas, Hana Kostrhunova, Vojtech Novohradsky, Christoph Janiak, José Ruiz, Viktor Brabec

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 24(18)

A series of five kinetically inert bis-cyclometalated IrIII complexes of general formula [Ir(C^N)2 (N^N)][PF6 ] [C^N=2-phenyl-1-[4-(trifluoromethyl)benzyl]-1H-benzo[d]imidazol-κN,C; N^N=1,10-phenanthroline (phen, 1), dipyrido[3,2-d:2',3'-f]quinoxali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd7729ff6c2f501bd866e14f775b994
https://pubmed.ncbi.nlm.nih.gov/29369444

Anticancer cyclometalated complexes of platinum group metals and gold

Autor: Consuelo Vicente, Natalia Cutillas, José Ruiz, Concepción de Haro, Gorakh S. Yellol, Venancio Rodríguez

Publikováno v: DIGITUM: Depósito Digital Institucional de la Universidad de Murcia
Universidad de Murcia
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
instname

The clinical success of cisplatin and its derivatives has had an enormous impact on the discovery of novel metal-based drugs. Extensive studies have focused on the interaction of metal complexes with their potential targets. The array of organometall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562dc43672de7e6bf06e2c9c855ef1d9
https://doi.org/10.1016/j.ccr.2013.03.024

A Potent Ruthenium(II) Antitumor Complex Bearing a Lipophilic Levonorgestrel Group

Autor: José Ruiz, Natalia Cutillas, Arturo Espinosa, Venancio Rodríguez, Michael J. Hannon

Publikováno v: Inorganic Chemistry. 50:9164-9171

The novel steroidal conjugate 17-α-[2-phenylpyridyl-4-ethynyl]-19-nortestosterone (LEV-ppy) (1) and the steroid-C,N-chelate ruthenium(II) conjugate [Ru(η(6)-p-cymene)(LEV-ppy)Cl] (2) have been prepared. At 48 h incubation time, complex 2 is more ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0a45ef2dfc0203055a0b020f0e8aef
https://doi.org/10.1021/ic201388n