P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles

Autor: Robin M. H. Rumney, Justyna Róg, Natalia Chira, Alexander P. Kao, Rasha Al-Khalidi, Dariusz C. Górecki

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly with macrophage infiltration, suggesting a link between ectopic mineral depo

Externí odkaz: https://doaj.org/article/37e4dfc22c994e55a84943a00d70969a

Total Absence of Dystrophin Expression Exacerbates Ectopic Myofiber Calcification and Fibrosis and Alters Macrophage Infiltration Patterns

Autor: J. Dunlop, Darek Gorecki, Aleksandra Oksiejuk, Maxime R. F. Gosselin, Kacper Łukasiewicz, Natalia Chira, Paweł Matryba, Robin M. H. Rumney, Alexander P. Kao, Christopher N. J. Young, Samuel Robson, Krzysztof Zabłocki, Lukasz Bozycki

Publikováno v: Young, C, Gosselin, M R F, Rumney, R M H, Oksiejuk, A, Chira, N, Bozycki, L, Matryba, P, Łukasiewicz, K, Kao, A, Dunlop, J N, Robson, S, Zabłocki, K & Gorecki, D 2020, ' Total absence of dystrophin expression exacerbates ectopic myofiber calcification and fibrosis and alters macrophage infiltration patterns ', American Journal of Pathology, vol. 190, no. 1, pp. 190-205 . https://doi.org/10.1016/j.ajpath.2019.09.021

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Duchenne muscular dystrophy (DMD) causes severe disability and death of young men due to progressive m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2421c92eb4330bb99f188781cca4375
https://pubmed.ncbi.nlm.nih.gov/31726040