Figure S6 from Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861

Autor: Kairbaan M. Hodivala-Dilke, Thomas Iskratsch, Maddy Parsons, Bryan Serrels, Bernardo Tavora, Silvia Batista, Annika N. Alexopoulou, Vassiliki Kostourou, Delphine M. Lees, Isabelle Fernandez, Paraskivi Natalia Georgiou, Louise E. Reynolds, Edward P. Carter, Jesus Gomez-Escudero, Natalia Bodrug, Ana-Rita Pedrosa

Supplementary Figure 6. Knocking down Ang-2 in B16F0s cells ablates angiogenic response in ECCre+;FAKY861F/Y861F mice in vivo.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ed9c4100bd25c2f70043fe68231339
https://doi.org/10.1158/0008-5472.22422225.v1

Data from Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861

Autor: Kairbaan M. Hodivala-Dilke, Thomas Iskratsch, Maddy Parsons, Bryan Serrels, Bernardo Tavora, Silvia Batista, Annika N. Alexopoulou, Vassiliki Kostourou, Delphine M. Lees, Isabelle Fernandez, Paraskivi Natalia Georgiou, Louise E. Reynolds, Edward P. Carter, Jesus Gomez-Escudero, Natalia Bodrug, Ana-Rita Pedrosa

Expression of focal adhesion kinase (FAK) in endothelial cells (EC) is essential for angiogenesis, but how FAK phosphorylation at tyrosine-(Y)397 and Y861 regulate tumor angiogenesis in vivo is unknown. Here, we show that tumor growth and angiogenesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1eee9a002e76a2569618268b1a0af530
https://doi.org/10.1158/0008-5472.c.6511158.v1

Figure S7 from Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861

Autor: Kairbaan M. Hodivala-Dilke, Thomas Iskratsch, Maddy Parsons, Bryan Serrels, Bernardo Tavora, Silvia Batista, Annika N. Alexopoulou, Vassiliki Kostourou, Delphine M. Lees, Isabelle Fernandez, Paraskivi Natalia Georgiou, Louise E. Reynolds, Edward P. Carter, Jesus Gomez-Escudero, Natalia Bodrug, Ana-Rita Pedrosa

Supplementary Figure 7. Loss of endothelial cell FAK-Y397 or FAK-Y861-phosphorylation does not affect total levels of β1 Integrin, but affects clustering at focal contact sites.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8d3777bbcd7178823c9b386a6b6e0f
https://doi.org/10.1158/0008-5472.22422222

ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning

Autor: Gabriela D'Amico, Isabelle Fernandez, Jesús Gómez-Escudero, Hyojin Kim, Eleni Maniati, Muhammad Syahmi Azman, Faraz K. Mardakheh, Bryan Serrels, Alan Serrels, Maddy Parsons, Anthony Squire, Graeme M. Birdsey, Anna M. Randi, Alfonso Bolado-Carrancio, Rathi Gangeswaran, Louise E. Reynolds, Natalia Bodrug, Yaohe Wang, Jun Wang, Pascal Meier, Kairbaan M. Hodivala-Dilke

Publikováno v: D'amico, G, Fernandez, I, Gómez-escudero, J, Kim, H, Maniati, E, Azman, M S, Mardakheh, F K, Serrels, B, Serrels, A, Parsons, M, Squire, A, Birdsey, G M, Randi, A M, Bolado-carrancio, A, Gangeswaran, R, Reynolds, L E, Bodrug, N, Wang, Y, Wang, J, Meier, P & Hodivala-dilke, K M 2022, ' ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning ', Development, vol. 149, no. 13, dev200528 . https://doi.org/10.1242/dev.200528

Precise vascular patterning is crucial for normal growth and development. The ERG transcription factor drives Delta-like ligand 4 (DLL4)/Notch signalling and is thought to act as a pivotal regulator of endothelial cell (EC) dynamics and developmental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8d1df014fcaf9eb06716278dbabc54
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85134426448

Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells

Autor: Thomas J. Schall, Neil C. Henderson, Natalia Bodrug, Maruan Hijazi, Matthew Dukinfield, Qiong Meng, Penglie Zhang, Louise E. Reynolds, Yu Wang, José M. Muñoz-Félix, Kylie P. Matchett, S. Dreger, Hyojin Kim, John G. Gribben, Irene Rodriguez-Hernandez, Oscar Maiques, Ya-Ming Meng, George Elia, James Campbell, Pedro R. Cutillas, Andrew Clear, Beatriz de Luxán-Delgado, Kairbaan Hodivala-Dilke, Pascal Meier, Stephen D. Robinson, Ping-Pui Wong, Sally Smith, Peter W. Szlosarek, J. Louise Jones, Rajinder Singh, Catherine A. Harwood, Victoria Sanz-Moreno

Publikováno v: Cell. 181:1346-1363.e21

Enhanced blood vessel (BV) formation is thought to drive tumor growth through elevated nutrient delivery. However, this observation has overlooked potential roles for mural cells in directly affecting tumor growth independent of BV function. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9915c367f4f39b1a648daf34fa228c58
https://doi.org/10.1016/j.cell.2020.02.003