Figure S6 from Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861

Autor: Kairbaan M. Hodivala-Dilke, Thomas Iskratsch, Maddy Parsons, Bryan Serrels, Bernardo Tavora, Silvia Batista, Annika N. Alexopoulou, Vassiliki Kostourou, Delphine M. Lees, Isabelle Fernandez, Paraskivi Natalia Georgiou, Louise E. Reynolds, Edward P. Carter, Jesus Gomez-Escudero, Natalia Bodrug, Ana-Rita Pedrosa

Supplementary Figure 6. Knocking down Ang-2 in B16F0s cells ablates angiogenic response in ECCre+;FAKY861F/Y861F mice in vivo.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ed9c4100bd25c2f70043fe68231339
https://doi.org/10.1158/0008-5472.22422225.v1

ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning

Autor: Gabriela D'Amico, Isabelle Fernandez, Jesús Gómez-Escudero, Hyojin Kim, Eleni Maniati, Muhammad Syahmi Azman, Faraz K. Mardakheh, Bryan Serrels, Alan Serrels, Maddy Parsons, Anthony Squire, Graeme M. Birdsey, Anna M. Randi, Alfonso Bolado-Carrancio, Rathi Gangeswaran, Louise E. Reynolds, Natalia Bodrug, Yaohe Wang, Jun Wang, Pascal Meier, Kairbaan M. Hodivala-Dilke

Publikováno v: D'amico, G, Fernandez, I, Gómez-escudero, J, Kim, H, Maniati, E, Azman, M S, Mardakheh, F K, Serrels, B, Serrels, A, Parsons, M, Squire, A, Birdsey, G M, Randi, A M, Bolado-carrancio, A, Gangeswaran, R, Reynolds, L E, Bodrug, N, Wang, Y, Wang, J, Meier, P & Hodivala-dilke, K M 2022, ' ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning ', Development, vol. 149, no. 13, dev200528 . https://doi.org/10.1242/dev.200528

Precise vascular patterning is crucial for normal growth and development. The ERG transcription factor drives Delta-like ligand 4 (DLL4)/Notch signalling and is thought to act as a pivotal regulator of endothelial cell (EC) dynamics and developmental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8d1df014fcaf9eb06716278dbabc54
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85134426448

Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells

Autor: Thomas J. Schall, Neil C. Henderson, Natalia Bodrug, Maruan Hijazi, Matthew Dukinfield, Qiong Meng, Penglie Zhang, Louise E. Reynolds, Yu Wang, José M. Muñoz-Félix, Kylie P. Matchett, S. Dreger, Hyojin Kim, John G. Gribben, Irene Rodriguez-Hernandez, Oscar Maiques, Ya-Ming Meng, George Elia, James Campbell, Pedro R. Cutillas, Andrew Clear, Beatriz de Luxán-Delgado, Kairbaan Hodivala-Dilke, Pascal Meier, Stephen D. Robinson, Ping-Pui Wong, Sally Smith, Peter W. Szlosarek, J. Louise Jones, Rajinder Singh, Catherine A. Harwood, Victoria Sanz-Moreno

Publikováno v: Cell. 181:1346-1363.e21

Enhanced blood vessel (BV) formation is thought to drive tumor growth through elevated nutrient delivery. However, this observation has overlooked potential roles for mural cells in directly affecting tumor growth independent of BV function. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9915c367f4f39b1a648daf34fa228c58
https://doi.org/10.1016/j.cell.2020.02.003

Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice

Autor: Annika N, Alexopoulou, Delphine M, Lees, Natalia, Bodrug, Tanguy, Lechertier, Isabelle, Fernandez, Gabriela, D'Amico, Matthew, Dukinfield, Silvia, Batista, Bernardo, Tavora, Bryan, Serrels, Kairbaan, Hodivala-Dilke

Publikováno v: The Journal of Pathology

Focal adhesion kinase (FAK) inhibitors have been developed as potential anticancer agents and are undergoing clinical trials. In vitro activation of the FAK kinase domain triggers autophosphorylation of Y397, Src activation, and subsequent phosphoryl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd80e35ec4b818a6fab319df5cf7e05b
https://pubmed.ncbi.nlm.nih.gov/28444899

The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines

Autor: Quentin Chevy, Gregory Gauvain, Jean Christophe Poncer, Theano Irinopoulou, Ingrid Chamma, Carolina Cabezas, Michèle Carnaud, Natalia Bodrug, Sabine Lévi

Publikováno v: Proceedings of the National Academy of Sciences. 108:15474-15479

The K-Cl cotransporter KCC2 plays an essential role in neuronal chloride homeostasis, and thereby influences the efficacy and polarity of GABA signaling. Although KCC2 is expressed throughout the somatodendritic membrane, it is remarkably enriched in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e493b2582eb8832134b66224f92d2d
https://doi.org/10.1073/pnas.1107893108