Výsledky vyhledávání - "Natalia B Carvalho"

Akademický článek

MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infection.

Autor: Leonardo A de Almeida, Natalia B Carvalho, Fernanda S Oliveira, Thais L S Lacerda, Anilton C Vasconcelos, Lucas Nogueira, Andre Bafica, Aristóbolo M Silva, Sergio C Oliveira

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23135 (2011)

Type I interferons (IFNs) are cytokines that orchestrate diverse immune responses to viral and bacterial infections. Although typically considered to be most important molecules in response to viruses, type I IFNs are also induced by most, if not all

Externí odkaz: https://doaj.org/article/3ba03d11c2c04264a8176780cec9f668

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Toll-like receptor 6 sensesMycobacterium aviumand is required for efficient control of mycobacterial infection

Autor: Natalia B. Carvalho, Sergio C. Oliveira, Fernanda S. Oliveira, Rafaella R. de Paula, Marcelo Vidigal Caliari, Leonardo A. de Almeida, Fábio V. Marinho, Aline C. Mendes, Marco Túlio R. Gomes

Publikováno v: European Journal of Immunology. 43:2373-2385

Mycobacterium avium has been reported to signal through both Toll-like receptor (TLR2) and TLR9. To investigate the role of TLR6 in innate immune responses to M. avium, TLR6, MyD88, TLR2, and TLR2/6 KO mice were infected with this pathogen. Bacterial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e290fd67b909aa38fd359809e438fc44
https://doi.org/10.1002/eji.201243208

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Update on the role of innate immune receptors during Brucella abortus infection

Autor: Leonardo A. de Almeida, Sergio C. Oliveira, Thais Lourdes Santos Lacerda, Natalia B. Carvalho, Fernanda S. Oliveira

Publikováno v: Veterinary Immunology and Immunopathology. 148:129-135

The innate immune system constitutes an efficient defense mechanism against invading microbial pathogens. Recent studies have revealed the intracellular signaling cascades involved in the TLR-initiated immune response to Brucella spp. infection. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f996fd2450b5707f5d6abab6e7ba9174
https://doi.org/10.1016/j.vetimm.2011.05.036

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Nucleotide-Binding Oligomerization Domain-1 and -2 Play No Role in ControllingBrucella abortusInfection in Mice

Autor: Natalia B. Carvalho, Fernanda S. Oliveira, Dario S. Zamboni, Sergio C. Oliveira

Publikováno v: Clinical and Developmental Immunology, Vol 2012 (2012)
Clinical and Developmental Immunology

Nucleotide-binding oligomerization domain proteins (NODs) are modular cytoplasmic proteins implicated in the recognition of peptidoglycan-derived molecules. Further, severalin vivostudies have demonstrated a role for Nod1 and Nod2 in host defense aga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f636dbc597498474398ac4b9e2a6f22c
https://doi.org/10.1155/2012/861426

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Toll-Like Receptor 9 Is Required for Full Host Resistance to Mycobacterium avium Infection but Plays No Role in Induction of Th1 Responses

Autor: Rui Appelberg, Manuela Flórido, Sergio C. Oliveira, Luana O Prata, Fernanda do Valle Durães, Fernanda S. Oliveira, Leonardo A. de Almeida, Natalia B. Carvalho, Marcelo Vidigal Caliari

Publikováno v: Infection and Immunity. 79:1638-1646

To investigate the role of Toll-like receptor 9 (TLR9) in innate immunity to Mycobacterium avium , TLR9, TLR2, and MyD88 knockout (KO) mice were infected with this bacterium. Bacterial burdens were higher in the spleens, livers, and lungs of infected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e7bcfd2c2a523f5325432d040f872d
https://doi.org/10.1128/iai.01030-10

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IL-12 and TNF-α production by dendritic cells stimulated with Schistosoma mansoni schistosomula tegument is TLR4- and MyD88-dependent

Autor: Sergio C. Oliveira, Fernanda do Valle Durães, Tatiane Teixeira de Melo, Cristina Toscano Fonseca, Natalia B. Carvalho

Publikováno v: Immunology Letters. 125:72-77

Schistosoma mansoni schistosomula are the most susceptible parasite life stage to host immune system attack. Complex host-parasite interactions take place on Schistosoma tegument, which is a unique double membrane structure involved in nutrition and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfbac4102d5918bc3ee64c2dd82b38ba
https://doi.org/10.1016/j.imlet.2009.06.004

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5-Lipoxygenase Negatively Regulates Th1 Response during Brucella abortus Infection in Mice

Autor: Sergio C. Oliveira, Mariana Bueno de Souza, Marco Túlio R. Gomes, Patricia P. Corsetti, Fábio V. Marinho, Leonardo A. de Almeida, Natalia B. Carvalho, Júlia S. Fahel, Marcelo Vidigal Caliari, Fabiana S. Machado

Brucella abortus is a Gram-negative bacterium that infects humans and cattle, causing a chronic inflammatory disease known as brucellosis. A Th1-mediated immune response plays a critical role in host control of this pathogen. Recent findings indicate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b111305c72c9822d6395f518dcadd8e
https://europepmc.org/articles/PMC4333460/

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Nucleotide-binding oligomerization domain-2 (NOD2) regulates type-1 cytokine responses to Mycobacterium avium but is not required for host control of infection

Autor: Natalia B. Carvalho, Fábio V. Marinho, Júlia S. Fahel, Leonardo A. de Almeida, Antonio Gigliotti Rothfuchs, André Báfica, Fernanda S. Oliveira, Dario S. Zamboni, Sergio C. Oliveira, Marcelo Vidigal Caliari

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Nucleotide-binding oligomerization domain-2 (NOD2) is an innate immune receptor that recognizes peptidoglycan-derived muramyl dipeptide from intracellular bacteria and triggers proinflammatory signals. In this study, we sought to evaluate the role pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46e90d1586ac67d6ca939ed07c5422b
https://pubmed.ncbi.nlm.nih.gov/25817335

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Key role of Toll-like receptor 2 in the inflammatory response and major histocompatibility complex class ii downregulation in Brucella abortus-infected alveolar macrophages

Autor: Natalia B. Carvalho, Paula Barrionuevo, Pablo C. Baldi, M. Soledad Hielpos, Mariana C. Ferrero, Sergio C. Oliveira, Patricia P. Corsetti, Guillermo H. Giambartolomei

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Alveolar macrophages (AM) seem to constitute the main cellular target of inhaled brucellae. Here, we show that Brucella abortus invades and replicates in murine AM without inducing cytotoxicity. B. abortus infection induced a statistically significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5486d65c43c925d4cc3b667d1d23838d
https://pubmed.ncbi.nlm.nih.gov/24478078

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Host Susceptibility to Brucella abortus Infection Is More Pronounced in IFN-γ knockout than IL-12/β2-Microglobulin Double-Deficient Mice

Autor: Sergio C. Oliveira, Vasco Azevedo, Gilson Costa Macedo, Ana Paula Macedo de Souza Brandão, Leda Quercia Vieira, Natalia B. Carvalho, Fernanda S. Oliveira

Publikováno v: Clinical and Developmental Immunology
Clinical and Developmental Immunology, Vol 2012 (2012)

Brucella abortusis a facultative intracellular bacterial pathogen that causes abortion in domestic animals and undulant fever in humans. IFN-γ, IL-12, and CD8+ T lymphocytes are important components of host immune responses againstB. abortus. Herein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018ca87407b882e238ef266b02c59c4c
http://europepmc.org/articles/PMC3238360

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