Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Natalia A. Vilchinskaya"'
Autor:
Timur M. Mirzoev, Inna I. Paramonova, Sergey V. Rozhkov, Ekaterina P. Kalashnikova, Svetlana P. Belova, Sergey A. Tyganov, Natalia A. Vilchinskaya, Boris S. Shenkman
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 4, Pp 3068-3086 (2023)
Currently, no ideal treatment exists to combat skeletal muscle disuse-induced atrophy and loss of strength. Because the activity of AMP-activated protein kinase (AMPK) in rat soleus muscle is suppressed at the early stages of disuse, we hypothesized
Externí odkaz:
https://doaj.org/article/05997466fa9b47ff9d3c3546c6030e78
Autor:
Natalia A. Vilchinskaya, Sergey V. Rozhkov, Olga V. Turtikova, Timur M. Mirzoev, Boris S. Shenkman
Publikováno v:
Cells, Vol 12, Iss 6, p 920 (2023)
Regrowth of atrophied myofibers depends on muscle satellite cells (SCs) that exist outside the plasma membrane. Muscle atrophy appears to result in reduced number of SCs due to apoptosis. Given reduced AMP-activated protein kinase (AMPK) activity dur
Externí odkaz:
https://doaj.org/article/c6433ea5a2994c25b30a1686a2bdb8eb
Autor:
Margarita Y. Komarova, Sergey V. Rozhkov, Oksana A. Ivanova, Olga V. Turtikova, Timur M. Mirzoev, Renata I. Dmitrieva, Boris S. Shenkman, Natalia A. Vilchinskaya
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9150 (2022)
The structure and function of soleus muscle fibers undergo substantial remodeling under real or simulated microgravity conditions. However, unloading-induced changes in the functional activity of skeletal muscle primary myoblasts remain poorly studie
Externí odkaz:
https://doaj.org/article/9fb3d24a5d914112bf1a90b8059d1d4f
Autor:
Kristina A. Sharlo, Inna I. Paramonova, Irina D. Lvova, Natalia A. Vilchinskaya, Anna E. Bugrova, Tatiana F. Shevchenko, Grigoriy R. Kalamkarov, Boris S. Shenkman
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
It is known that nitric oxide (NO) may affect myosin heavy chain (MyHC) isoform mRNA transcription in skeletal muscles. The content of NO in soleus muscles decreases during rat hindlimb unloading as well as slow MyHC mRNA transcription. We aimed to d
Externí odkaz:
https://doaj.org/article/12c8feafe1cf41a8bde5ea9da98f7146
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1167 (2021)
It is well known that reduced contractile activity of the main postural soleus muscle during long-term bedrest, immobilization, hindlimb unloading, and space flight leads to increased expression of fast isoforms and decreased expression of the slow i
Externí odkaz:
https://doaj.org/article/b858ef8b4b1f4fc0af047323449ffc27
Autor:
Violetta V. Kravtsova, Inna I. Paramonova, Natalia A. Vilchinskaya, Maria V. Tishkova, Vladimir V. Matchkov, Boris S. Shenkman, Igor I. Krivoi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3920 (2021)
Sustained sarcolemma depolarization due to loss of the Na,K-ATPase function is characteristic for skeletal muscle motor dysfunction. Ouabain, a specific ligand of the Na,K-ATPase, has a circulating endogenous analogue. We hypothesized that the Na,K-A
Externí odkaz:
https://doaj.org/article/632d78931b5e42db8f22665c21a05813
Autor:
Sergey A. Tyganov, Ekaterina P. Mochalova, Svetlana P. Belova, Kristina A. Sharlo, Sergey V. Rozhkov, Natalia A. Vilchinskaya, Inna I. Paramonova, Timur M. Mirzoev, Boris S. Shenkman
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
It is known that plantar mechanical stimulation (PMS) is able to attenuate unloading-induced skeletal muscle atrophy and impaired muscle function. However, molecular mechanisms underlying the effect of PMS on skeletal muscle during unloading remain u
Externí odkaz:
https://doaj.org/article/f78966b292b34363af1b1afd20075cea
Autor:
Kristina A. Sharlo, Inna I. Paramonova, Irina D. Lvova, Ekaterina P. Mochalova, Vitaliy E. Kalashnikov, Natalia A. Vilchinskaya, Sergey A. Tyganov, Tatyana S. Konstantinova, Tatiana F. Shevchenko, Grigoriy R. Kalamkarov, Boris S. Shenkman
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1372 (2021)
It was observed that gravitational unloading during space missions and simulated microgravity in ground-based studies leads to both transformation of slow-twitch muscle fibers into fast-twitch fibers and to the elimination of support afferentation, l
Externí odkaz:
https://doaj.org/article/cc3baaab69a84086a5b46d44872887a7
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3558 (2018)
Molecular mechanisms that trigger disuse-induced postural muscle atrophy as well as myosin phenotype transformations are poorly studied. This review will summarize the impact of 5′ adenosine monophosphate -activated protein kinase (AMPK) activity o
Externí odkaz:
https://doaj.org/article/1bc8e7fd3c474a518f31f5fd89952d8e
Publikováno v:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 14:242-248
Gravitational unloading leads to a slow-to-fast shift in the myosin phenotype. The reason for these changes is a decrease in the expression of the genes encoding heavy chains of myosin (MyHC) of the slow type, and an increase in the expression of the