Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Natalia A. Tamarina"'
Publikováno v:
Frontiers in Endocrinology, Vol 7 (2016)
Growth hormone-releasing hormone (GHRH) is produced by the hypothalamus and stimulates growth hormone synthesis and release in the anterior pituitary gland. In addition GHRH is an important regulator of cellular functions in many cells and organs. Ex
Externí odkaz:
https://doaj.org/article/c43ea212ce3a47508f16a948f55a64aa
Autor:
Fan Fan, Dan Nerad, Xuelin Lou, Adam Rizk, Natalia A. Tamarina, Manami Hara, Chen Ji, Yumei Wu
Publikováno v:
Proc Natl Acad Sci U S A
Pancreatic β cells operate with a high rate of membrane recycling for insulin secretion, yet endocytosis in these cells is not fully understood. We investigate this process in mature mouse β cells by genetically deleting dynamin GTPase, the membran
Autor:
Christopher J. Rhodes, Louis H. Philipson, Lynn W. Enquist, Inderroop Singh, Jonathan N. Flak, Thomas C. Becker, Natalia A. Tamarina, Martin G. Myers, Christa M. Patterson, Wilfredo Rosario, Arnaud Wautlet, Almas Ali
Publikováno v:
Diabetes. 65:2711-2723
The brain influences glucose homeostasis, partly by supplemental control over insulin and glucagon secretion. Without this central regulation, diabetes and its complications can ensue. Yet, the neuronal network linking to pancreatic islets has never
Autor:
Yumei Wu, Louis H. Philipson, Pietro De Camilli, Natalia A. Tamarina, Jenifer Wendlick, Shawn M. Ferguson, Fan Fan, Xuelin Lou
Publikováno v:
Biophysical Journal. 118:488a
Autor:
Chen Ji, Fan Fan, Louis H. Philipson, Xuelin Lou, Natalia A. Tamarina, Shawn M. Ferguson, Yumei Wu
Publikováno v:
Journal of Clinical Investigation. 125:4026-4041
Alterations in insulin granule exocytosis and endocytosis are paramount to pancreatic β cell dysfunction in diabetes mellitus. Here, using temporally controlled gene ablation specifically in β cells in mice, we identified an essential role of dynam
Autor:
Jun Namkung, Chang-Myung Oh, Gerard Karsenty, Natalia A. Tamarina, Hail Kim, Mica Ohara-Imaizumi, Sangkyu Park, Louis H. Philipson, Michael S. German, Kyuho Kim, Shinya Nagamatsu, Vijay K. Yadav, Michael W. Roe
Publikováno v:
Endocrinology. 156:444-452
The physiological role of serotonin, or 5-hydroxytryptamine (5-HT), in pancreatic β-cell function was previously elucidated using a pregnant mouse model. During pregnancy, 5-HT increases β-cell proliferation and glucose-stimulated insulin secretion
Autor:
Julien Ghislain, Louis H. Philipson, Natalia A. Tamarina, Kevin Vivot, Vincent Poitout, Jens Fielitz, Valérie Bergeron
Publikováno v:
Diabetes
Ββ-Cell adaptation to insulin resistance is necessary to maintain glucose homeostasis in obesity. Failure of this mechanism is a hallmark of type 2 diabetes (T2D). Hence, factors controlling functional β-cell compensation are potentially important
Autor:
Louis H. Philipson, Natalia A. Tamarina, Eric P. Smith, David A. D'Alessio, Bailing Li, Eric B. Cohen, Diego Perez-Tilve, Alfor G. Lewis, Darleen A. Sandoval, Parinaz Mahbod, Constance Wagner, Doris A. Stoffers, Zhibo An, Randy J. Seeley
Publikováno v:
Cell Metabolism. 19:1050-1057
Glucagon-like peptide-1 (GLP-1), an insulinotropic peptide released from the intestine after eating, is essential for normal glucose tolerance (GT). To determine whether this effect is mediated directly by GLP-1 receptors (GLP1R) on islet β-cells, w
Autor:
Michael W. Roe, Lorna M. Dickson, Natalia A. Tamarina, David A. Jacobson, Louis H. Philipson, Barton Wicksteed, Kelly Kaihara
Publikováno v:
Diabetes
Acute insulin secretion determines the efficiency of glucose clearance. Moreover, impaired acute insulin release is characteristic of reduced glucose control in the prediabetic state. Incretin hormones, which increase β-cell cAMP, restore acute-phas
Bursting and calcium oscillations in pancreatic β-cells: specific pacemakers for specific mechanisms
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 299:E517-E532
Oscillatory phenomenon in electrical activity and cytoplasmic calcium concentration in response to glucose are intimately connected to multiple key aspects of pancreatic β-cell physiology. However, there is no single model for oscillatory mechanisms