Zobrazeno 1 - 10
of 485
pro vyhledávání: '"Natalia A Trayanova"'
Autor:
Yingnan Zhang, Kelly Zhang, Adityo Prakosa, Cynthia James, Stefan L Zimmerman, Richard Carrick, Eric Sung, Alessio Gasperetti, Crystal Tichnell, Brittney Murray, Hugh Calkins, Natalia A Trayanova
Publikováno v:
eLife, Vol 12 (2023)
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic cardiac disease that leads to ventricular tachycardia (VT), a life-threatening heart rhythm disorder. Treating ARVC remains challenging due to the complex underlying arrhythmogenic m
Externí odkaz:
https://doaj.org/article/729a8dbf99ec498d91aab5b43d975173
Autor:
Ryan P O'Hara, Edem Binka, Adityo Prakosa, Stefan L Zimmerman, Mark J Cartoski, M Roselle Abraham, Dai-Yin Lu, Patrick M Boyle, Natalia A Trayanova
Publikováno v:
eLife, Vol 11 (2022)
Hypertrophic cardiomyopathy (HCM) is associated with risk of sudden cardiac death (SCD) due to ventricular arrhythmias (VAs) arising from the proliferation of fibrosis in the heart. Current clinical risk stratification criteria inadequately identify
Externí odkaz:
https://doaj.org/article/41a1869802864523a63dd249be178dd7
Publikováno v:
Arrhythmia & Electrophysiology Review, Vol 8, Iss 3, Pp 210-219 (2019)
Externí odkaz:
https://doaj.org/article/27f2c0b40a0f402f8e385c546511d517
Autor:
Kathleen S McDowell, Sohail Zahid, Fijoy Vadakkumpadan, Joshua Blauer, Rob S MacLeod, Natalia A Trayanova
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156189 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0117110.].
Externí odkaz:
https://doaj.org/article/3735ea9938d64daa83ea51312ba0fde8
Autor:
Kathleen S McDowell, Sohail Zahid, Fijoy Vadakkumpadan, Joshua Blauer, Rob S MacLeod, Natalia A Trayanova
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117110 (2015)
Research has indicated that atrial fibrillation (AF) ablation failure is related to the presence of atrial fibrosis. However it remains unclear whether this information can be successfully used in predicting the optimal ablation targets for AF termin
Externí odkaz:
https://doaj.org/article/a4805994ab49422280fd6dc127d2c4bd
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 12, p e1004011 (2014)
Atrial fibrillation (AF) is the most common cardiac arrhythmia, but our knowledge of the arrhythmogenic substrate is incomplete. Alternans, the beat-to-beat alternation in the shape of cardiac electrical signals, typically occurs at fast heart rates
Externí odkaz:
https://doaj.org/article/62fe6d74723145ef8c28629095dc348b
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Under diseased conditions, remodeling of the cardiac tissue properties (passive properties) takes place; these are aspects of electrophysiological behavior that are not associated with active ion transport across cell membranes. Remodeling of the pas
Externí odkaz:
https://doaj.org/article/caecc77337314697b6b6731ed145d1ac
Autor:
Patrick M Boyle, Carolyn J Park, Hermenegild J Arevalo, Edward J Vigmond, Natalia A Trayanova
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86947 (2014)
Organ-scale arrhythmogenic consequences of source-sink mismatch caused by impaired excitability remain unknown, hindering the understanding of pathophysiology in disease states like Brugada syndrome and ischemia.We sought to determine whether sodium
Externí odkaz:
https://doaj.org/article/cd668bb0634041ec807bf22b8bdf0dea
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60287 (2013)
Recruitment of stretch-activated channels, one of the mechanisms of mechano-electric feedback, has been shown to influence the stability of scroll waves, the waves that underlie reentrant arrhythmias. However, a comprehensive study to examine the eff
Externí odkaz:
https://doaj.org/article/a3db4a92ec2e4f63befad652b429923b
Autor:
Natalia A Trayanova, John Jeremy Rice
Publikováno v:
Frontiers in Physiology, Vol 2 (2011)
The heart is a multiphysics and multiscale system that has driven the development of the most sophisticated mathematical models at the frontiers of computation physiology and medicine. This review focuses on electromechanical (EM) models of the heart
Externí odkaz:
https://doaj.org/article/62ddd6c203c2449e9cb4b5ee9cab45b5