Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Natalia A Riobo-Del Galdo"'
Autor:
David Mellis, Katherine A Staines, Silvia Peluso, Ioanna Ch Georgiou, Natalie Dora, Malgorzata Kubiak, Rob Van't Hof, Michela Grillo, Colin Farquharson, Elaine Kinsella, Anna Thornburn, Stuart H Ralston, Donald M Salter, Natalia A Riobo-Del Galdo, Robert E Hill, Mark Ditzel
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009275 (2021)
Mammalian Hedgehog (HH) signalling pathway plays an essential role in tissue homeostasis and its deregulation is linked to rheumatological disorders. UBR5 is the mammalian homologue of the E3 ubiquitin-protein ligase Hyd, a negative regulator of the
Externí odkaz:
https://doaj.org/article/7d80a4cd974e4d41902b984699e2a974
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0203170 (2018)
Primary cilia are solitary organelles that emanate from the plasma membrane during growth arrest in almost all mammalian cells. The canonical Hedgehog (HH) pathway requires trafficking of the G protein-coupled receptor SMOOTHENED (SMO) and the GLI tr
Externí odkaz:
https://doaj.org/article/c3ae9abe675b47678d2c435456e5ad1a
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197442 (2018)
The Hedgehog family of morphogens has long been known to utilize, through the 7-transmembrane protein Smoothened (Smo), the heterotrimeric G protein Gi in both canonical and noncanonical forms of signaling. Other G proteins, while not specifically ut
Externí odkaz:
https://doaj.org/article/730c0004abc74ee9b17d67bcf4dd63ab
Publikováno v:
Materials Today Bio, Vol 17, Iss , Pp 100502- (2022)
Tissue patterning is the result of complex interactions between transcriptional programs and various mechanical cues that modulate cell behaviour and drive morphogenesis. Vertebrate Hedgehog signalling plays key roles in embryogenesis and adult tissu
Externí odkaz:
https://doaj.org/article/bc73bb9078464564b2fa0512bf8a8485
Autor:
Nikolina Piteša, Matea Kurtović, Nenad Bartoniček, Danai S. Gkotsi, Josipa Čonkaš, Tina Petrić, Vesna Musani, Petar Ozretić, Natalia A. Riobo-Del Galdo, Maja Sabol
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1353 (2023)
Background: Melanoma represents the deadliest skin cancer due to its cell plasticity which results in high metastatic potential and chemoresistance. Melanomas frequently develop resistance to targeted therapy; therefore, new combination therapy strat
Externí odkaz:
https://doaj.org/article/7811c878ae2d499a90e99e0c7299f803
Autor:
Mimmu K. Hiltunen, Alex J. Timmis, Maren Thomsen, Danai S. Gkotsi, Hideo Iwaï, Orquidea M. Ribeiro, Adrian Goldman, Natalia A. Riobo-Del Galdo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2682 (2023)
Deleterious mutations in the X-linked Patched domain-containing 1 (PTCHD1) gene may account for up to 1% of autism cases. Despite this, the PTCHD1 protein remains poorly understood. Structural similarities to Patched family proteins point to a role i
Externí odkaz:
https://doaj.org/article/7d7d3a2e196843389483252be995e8b6
Autor:
Begoña Caballero-Ruiz, Danai S. Gkotsi, Hattie Ollerton, Cintli C. Morales-Alcala, Rosa Bordone, Georgia M. L. Jenkins, Laura Di Magno, Gianluca Canettieri, Natalia A. Riobo-Del Galdo
Publikováno v:
Cancers, Vol 15, Iss 2, p 369 (2023)
The Hedgehog receptor, Patched1 (PTCH1), is a well-known tumour suppressor. While the tumour suppressor’s activity is mostly ascribed to its function as a repressor of the canonical Smoothened/Gli pathway, its C-terminal domain (CTD) was reported t
Externí odkaz:
https://doaj.org/article/5cc3ba1305fe4907a49316da24dad6df
Autor:
Christopher W. Wasson, Rebecca L. Ross, Rebecca Wells, Clarissa Corinaldesi, Ioanna Ch. Georgiou, Natalia A. Riobo-Del Galdo, Francesco Del Galdo
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-15 (2020)
Abstract Objectives Systemic sclerosis (SSc) is characterised by tissue fibrosis of the major organs of the body including the skin, lungs and heart. We have previously reported that the lncRNA HOTAIR plays a central role in the activation of SSc myo
Externí odkaz:
https://doaj.org/article/183b5f5be4e0494eacc1b87be0018035
Autor:
Christopher W. Wasson, Begoña Caballero-Ruiz, Justin Gillespie, Emma Derrett-Smith, Jamel Mankouri, Christopher P. Denton, Gianluca Canettieri, Natalia A. Riobo-Del Galdo, Francesco Del Galdo
Publikováno v:
Cells, Vol 11, Iss 3, p 530 (2022)
Chloride intracellular channel 4 (CLIC4) is a recently discovered driver of fibroblast activation in Scleroderma (SSc) and cancer-associated fibroblasts (CAF). CLIC4 expression and activity are regulated by TGF-β signalling through the SMAD3 transcr
Externí odkaz:
https://doaj.org/article/5105cddab7e6456bac4e7abafd440843
Publikováno v:
Cells, Vol 10, Iss 8, p 2003 (2021)
The Hedgehog (Hh) receptor PTCH1 and the integral membrane protein 2A (ITM2A) inhibit autophagy by reducing autolysosome formation. In this study, we demonstrate that ITM2A physically interacts with PTCH1; however, the two proteins inhibit autophagic
Externí odkaz:
https://doaj.org/article/dbe133a7ee3a485c97f1740227b62750