Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Natal A van Riel"'
Autor:
Shauna D. O’Donovan, Milena Rundle, E. Louise Thomas, Jimmy D. Bell, Gary Frost, Doris M. Jacobs, Anne Wanders, Ryan de Vries, Edwin C.M. Mariman, Marleen A. van Baak, Luc Sterkman, Max Nieuwdorp, Albert K. Groen, Ilja C.W. Arts, Natal A.W. van Riel, Lydia A. Afman
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109362- (2024)
Summary: The manifestation of metabolic deteriorations that accompany overweight and obesity can differ greatly between individuals, giving rise to a highly heterogeneous population. This inter-individual variation can impede both the provision and a
Externí odkaz:
https://doaj.org/article/1afe869749f64bceae5d59aec0da226c
Autor:
Vehpi Yildirim, Kasper W. ter Horst, Pim W. Gilijamse, Dewi van Harskamp, Henk Schierbeek, Hans Jansen, Alinda W.M. Schimmel, Max Nieuwdorp, Albert K. Groen, Mireille J. Serlie, Natal A.W. van Riel, Geesje M. Dallinga-Thie
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Dyslipidemia in obesity results from excessive production and impaired clearance of triglyceride-rich (TG-rich) lipoproteins, which are particularly pronounced in the postprandial state. Here, we investigated the impact of Roux-en-Y gastric bypass (R
Externí odkaz:
https://doaj.org/article/0f159909912c460780398d2a0da730af
Autor:
Bart van Sloun, Gijs H. Goossens, Balázs Erdõs, Shauna D. O’Donovan, Cécile M. Singh-Povel, Jan M.W. Geurts, Natal A.W. van Riel, Ilja C.W. Arts
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106218- (2023)
Summary: Current computational models of whole-body glucose homeostasis describe physiological processes by which insulin regulates circulating glucose concentrations. While these models perform well in response to oral glucose challenges, interactio
Externí odkaz:
https://doaj.org/article/15081f4035a64733ae4d95865ab884a1
Autor:
Albert Wolthuis, Petra F G Wolffs, Tim Frenzel, Mathie P G Leers, Frank van Rosmalen, Steven JR Meex, Otto Bekers, Bas C T van Bussel, Inge H M van Loo, Guy JM Mostard, Rémy LM Mostard, Arjen-Kars Boer, Ruben Deneer, Tom Schoenmakers, Stefan H M Gorissen, Wilhelmine P H G Verboeket-van de Venne, Walter N K A van Mook, Stephanie MC Ament, M Sesmu Arbous, Miranda van Berkel, Dirck W van Dam, William PTM van Doorn, Tom P Dormans, Silvia MAA Evers, Judith Gillis, Iwan CC van der Horst, W Nadia H Koek, Kitty CFM Linssen, Luuk C Otterspoor, Natal AW van Riel, Frans Stals
Publikováno v:
BMJ Open, Vol 13, Iss 2 (2023)
Introduction To investigate whether biochemical and haematological changes due to the patient’s host response (CoLab algorithm) in combination with a SARS-CoV-2 viability PCR (v-PCR) can be used to determine when a patient with COVID-19 is no longe
Externí odkaz:
https://doaj.org/article/b386ba789d24427e94352cedb9f943c5
Autor:
Shauna D. O’Donovan, Balázs Erdős, Doris M. Jacobs, Anne J. Wanders, E. Louise Thomas, Jimmy D. Bell, Milena Rundle, Gary Frost, Ilja C.W. Arts, Lydia A. Afman, Natal A.W. van Riel
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105206- (2022)
Summary: Despite the pivotal role played by elevated circulating triglyceride levels in the pathophysiology of cardio-metabolic diseases many of the indices used to quantify metabolic health focus on deviations in glucose and insulin alone. We presen
Externí odkaz:
https://doaj.org/article/b81561b698174b2a98bed0f081ce987f
Publikováno v:
Metabolic engineering, 77, 128-142. Academic Press Inc.
Lao-Martil, D, Schmitz, J P J, Teusink, B & van Riel, N A W 2023, ' Elucidating yeast glycolytic dynamics at steady state growth and glucose pulses through kinetic metabolic modeling ', Metabolic Engineering, vol. 77, pp. 128-142 . https://doi.org/10.1016/j.ymben.2023.03.005
Metabolic Engineering, 77, 128-142. Academic Press Inc.
Lao-Martil, D, Schmitz, J P J, Teusink, B & van Riel, N A W 2023, ' Elucidating yeast glycolytic dynamics at steady state growth and glucose pulses through kinetic metabolic modeling ', Metabolic Engineering, vol. 77, pp. 128-142 . https://doi.org/10.1016/j.ymben.2023.03.005
Metabolic Engineering, 77, 128-142. Academic Press Inc.
Microbial cell factories face changing environments during industrial fermentations. Kinetic metabolic models enable the simulation of the dynamic metabolic response to these perturbations, but their development is challenging due to model complexity
Publikováno v:
Patterns, Vol 1, Iss 6, Pp 100080- (2020)
Summary: Gene expression and protein abundance data of cells or tissues belonging to healthy and diseased individuals can be integrated and mapped onto genome-scale metabolic networks to produce patient-derived models. As the number of available and
Externí odkaz:
https://doaj.org/article/79e77f21ea2d49ea9a861c215e386219
Autor:
Yvonne J. Rozendaal, Anne H. Maas, Carola van Pul, Eduardus J. Cottaar, Harm R. Haak, Peter A. Hilbers, Natal A. van Riel
Publikováno v:
Clinical Nutrition Experimental, Vol 19, Iss , Pp 32-45 (2018)
Summary: Background & aims: Knowledge of postprandial glycemic response (PPGR) dynamics is important in nutrition management and diabetes research, care and (self)management. In daily life, food intake is the most important factor influencing the occ
Externí odkaz:
https://doaj.org/article/5e194ebef1c54a2cba48261cae46f4df
Autor:
Carmen Gensen, Saskia L M van Loon, Natal A van Riel, Simon Nienhuijs, Ralf Triepels, Snježana Kos, Alide H L Mulder, Nadine Pouw, Volkher Scharnhorst, Arjen Kars Boer
Publikováno v:
Journal of Applied Laboratory Medicine, 7(5):jfac017, 1062-1075. American Association for Clinical Chemistry Inc.
journal of applied laboratory medicine, 7(5), 1062-1075. Oxford University Press
journal of applied laboratory medicine, 7(5), 1062-1075. Oxford University Press
Background The metabolic health index (MHI) is a biomarker-based model that objectively assesses the cumulative impact of comorbidities type 2 diabetes mellitus, hypertension and dyslipidemia on the health state of bariatric patients. The MHI was dev
Autor:
David Lao-Martil, Koen J.A. Verhagen, Ana H. Valdeira Caetano, Ilse H. Pardijs, Natal A.W. van Riel, S. Aljoscha Wahl
Microbial metabolism is strongly dependent on the environmental conditions. While these can be well controlled under laboratory conditions, large-scale bioreactors are characterized by inhomogeneities and consequently dynamic conditions for the organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f975ffe957cc4a2612364dcea35bdbd5
https://doi.org/10.1101/2022.06.28.497175
https://doi.org/10.1101/2022.06.28.497175