VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness

Autor: Sandy Giuliano, Natacha Glisse, Gilles Pagès, Laetitia Douguet, Papa Diogop Ndiaye, Damien Ambrosetti, Valérie Vouret-Craviari, Baharia Mograbi, Maeva Dufies, Philippe Lenormand, Maud Wurmser, Nathalie Rioux-Leclercq, Pascal Maire, Jérôme Durivault, Janita Mintcheva, Renaud Grépin

Publikováno v: Theranostics
Theranostics, 2019, 9 (3), pp.661-675. ⟨10.7150/thno.27794⟩
Theranostics, Ivyspring International Publisher, 2019, 9 (3), pp.661-675. ⟨10.7150/thno.27794⟩

Hypoxic zones are common features of metastatic tumors. Due to inactivation of the von Hippel-Lindau gene (VHL), renal cell carcinomas (RCC) show constitutive stabilization of the alpha subunit of the hypoxia-inducible factor (HIF). Thus, RCC represe

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https://hal.science/hal-02454437/file/hal-02454437.pdf