Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Natacha Gaillard"'
Autor:
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip J. M. Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Chris Milne, Andrea Cavalli, Josef Wachtveitl, Michel O. Steinmetz, Jörg Standfuss
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Photopharmacology manipulates the biological activity of small molecules by light. Using an X-ray laser, the authors follow the release of the drug azo-combretastatin A4 from tubulin and the concomitant structural changes over nine orders of magnitud
Externí odkaz:
https://doaj.org/article/31ccc9f5c1c7420b8b23b5fa45bdc9ee
Autor:
Andrea E Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estevez-Gallego, Shuo Li, Katja Bargsten, Fernando Josa-Prado, Karl-Heinz Altmann, Natacha Gaillard, Shinji Kamimura, Tobias Mühlethaler, Federico Gago, Maria A Oliva, Michel O Steinmetz, Wei-Shuo Fang, J Fernando Díaz
Publikováno v:
eLife, Vol 12 (2023)
Paclitaxel (Taxol) is a taxane and a chemotherapeutic drug that stabilizes microtubules. While the interaction of paclitaxel with microtubules is well described, the lack of high-resolution structural information on a tubulin-taxane complex precludes
Externí odkaz:
https://doaj.org/article/ae0411d1a2f8477a839b678a56356407
Autor:
Charlotte Guyomar, Clément Bousquet, Siou Ku, John M Heumann, Gabriel Guilloux, Natacha Gaillard, Claire Heichette, Laurence Duchesne, Michel O Steinmetz, Romain Gibeaux, Denis Chrétien
Publikováno v:
eLife, Vol 11 (2022)
Microtubules are tubes of about 25 nm in diameter that are critically involved in a variety of cellular functions, including motility, compartmentalization, and division. They are considered as pseudo-helical polymers whose constituent αβ-tubulin h
Externí odkaz:
https://doaj.org/article/9c51fb0f95b84d70af1fa4796c5053a7
Autor:
Natacha Gaillard, Ashwani Sharma, Izra Abbaali, Tianyang Liu, Fiona Shilliday, Alexander D Cook, Valentin Ehrhard, Mamata Bangera, Anthony J Roberts, Carolyn A Moores, Naomi Morrissette, Michel O Steinmetz
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp n/a-n/a (2021)
Abstract Infectious diseases caused by apicomplexan parasites remain a global public health threat. The presence of multiple ligand‐binding sites in tubulin makes this protein an attractive target for anti‐parasite drug discovery. However, despit
Externí odkaz:
https://doaj.org/article/c0f9fdde1699413aa5e8e00497b1e055
Autor:
Andrea E Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estevez-Gallego, Shuo Li, Katja Bargsten, Fernando Josa-Prado, Karl-Heinz Altmann, Natacha Gaillard, Shinji Kamimura, Tobias Mühlethaler, Federico Gago, Maria A Oliva, Michel O Steinmetz, Wei-Shuo Fang, J Fernando Díaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6031650b263dc281c6bcce2894cf2134
https://doi.org/10.7554/elife.84791.sa2
https://doi.org/10.7554/elife.84791.sa2
Autor:
Charlotte Guyomar, Clément Bousquet, Siou Ku, John M Heumann, Gabriel Guilloux, Natacha Gaillard, Claire Heichette, Laurence Duchesne, Michel O Steinmetz, Romain Gibeaux, Denis Chrétien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3a8deed3fd0a50b8f8e23accf083d3a
https://doi.org/10.7554/elife.83021.sa2
https://doi.org/10.7554/elife.83021.sa2
Autor:
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Christopher Milne, Andrea Cavalli, Josef Wachtveitl, Michel Steinmetz, Jörg Standfuss
The binding and release of ligands from their protein targets is central to fundamental biological processes as well as to drug discovery. Photopharmacology introduces chemical triggers that allow the changing of ligand affinities and thus biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a72c6a2aafb8c867ef93395e8b9fb46
https://doi.org/10.21203/rs.3.rs-1964458/v1
https://doi.org/10.21203/rs.3.rs-1964458/v1
Autor:
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip J. M. Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Chris Milne, Andrea Cavalli, Josef Wachtveitl, Michel O. Steinmetz, Jörg Standfuss
The binding and release of ligands from their protein targets is central to fundamental biological processes as well as to drug discovery. Photopharmacology introduces chemical triggers that allow the changing of ligand affinities and thus biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3b074b5607c81bb186b5535b59bd61
https://doi.org/10.1101/2022.02.17.480857
https://doi.org/10.1101/2022.02.17.480857
Autor:
Carolyn A. Moores, Mamata Bangera, Valentin Ehrhard, Naomi S. Morrissette, Anthony J. Roberts, Natacha Gaillard, Izra Abbaali, Tianyang Liu, Fiona Shilliday, Ashwani Sharma, Michel O. Steinmetz, Alexander D. Cook
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp n/a-n/a (2021)
EMBO Molecular Medicine
EMBO Molecular Medicine
Infectious diseases caused by apicomplexan parasites remain a global public health threat. The presence of multiple ligand‐binding sites in tubulin makes this protein an attractive target for anti‐parasite drug discovery. However, despite remarka