Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1-AMPK-mTOR axis

Autor: Bong Gun Ju, Mi Mi Jang, Taek Yeol Jung, Jae Eun Ryu, Soh Yeon Lee, Hyelee Kim, Hyun-Seok Kim, Chae Young Lee, Chan Woo Kim, Cheolju Lee, Wankyu Kim, TaeSoo Kim, Eung Han Kim, Soo Young Lee, Seonjeong Lee, Sera Park, Gyu Rin Jin

Publikováno v: Experimental & Molecular Medicine

N-α-acetyltransferase 20 (Naa20), which is a catalytic subunit of the N-terminal acetyltransferase B (NatB) complex, has recently been reported to be implicated in hepatocellular carcinoma (HCC) progression and autophagy, but the underlying mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48b6927e74a9af43c2424f4fe2ff510
https://pubmed.ncbi.nlm.nih.gov/33219302

Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5

Autor: Nozomu Mori, Akira Kakizuka, Kazuko Onga, Kunihiko Yasuda, Kyoji Ohyama

Publikováno v: Gene expression patterns : GEP. 12(1-2)

The NatB complex, Nat5/Mdm20 acetyltransferase mediates N-acetylation to control cell cycle progression and actin dynamics in yeast. As yet, little is known about the expression pattern of Mdm20 and Nat5 in multi-cellular organisms. Here we show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285e22e581236d89c248872c160b5ce6
https://pubmed.ncbi.nlm.nih.gov/22101279

NatB-Mediated N-Terminal Acetylation Affects Growth and Biotic Stress Responses

Autor: Irmgard Sinning, Laura Armbruster, Carsten Sticht, Thierry Meinnel, Carmela Giglione, Dominik Layer, Markus Wirtz, Ruediger Hell, Willy V. Bienvenut, Iwona Stephan, Eric Linster, Monika Huber, Karine Lapouge

Publikováno v: Plant Physiology
Plant Physiology, American Society of Plant Biologists, 2020, 182 (2), pp.792-806. ⟨10.1104/pp.19.00792⟩
Plant Physiology, American Society of Plant Biologists, 2019, ⟨10.1104/pp.19.00792⟩
Plant Physiology, 2020, 182 (2), pp.792-806. ⟨10.1104/pp.19.00792⟩
Plant Physiol

International audience; N-terminal acetylation (NTA) is one of the most abundant protein modifications in eukaryotes. In humans, NTA is catalyzed by seven Nα-acetyltransferases (NatA-F and NatH). Remarkably, the plant Nat machinery and its biologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ab585d2829f11577b7b08f634b133f
https://doi.org/10.1104/pp.19.00792

The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains.

Autor: Knorr, Alexandra G.¹ (AUTHOR), Mackens-Kiani, Timur¹ (AUTHOR), Musial, Joanna¹ (AUTHOR), Berninghausen, Otto¹ (AUTHOR), Becker, Thomas¹ (AUTHOR), Beatrix, Birgitta¹ (AUTHOR) beatrix@genzentrum.lmu.de, Beckmann, Roland¹ (AUTHOR) beatrix@genzentrum.lmu.de

Publikováno v: PLoS Biology. 4/20/2023, Vol. 21 Issue 4, p1-28. 28p. 4 Graphs.

N-terminal acetylation promotes synaptonemal complex assembly in C. elegans

Autor: Jinmin Gao, Pan Zhang, Hyun-Min Kim, Vyacheslav M. Labunskyy, Enrique Martinez-Perez, Maxim V. Gerashchenko, Meng-Qiu Dong, Shangtong Li, Consuelo Barroso, James W. Lightfoot, Leticia Labrador, Monica P. Colaiácovo

Publikováno v: Genes and Development

N-terminal acetylation of the first two amino acids on proteins is a prevalent cotranslational modification. Despite its abundance, the biological processes associated with this modification are not well understood. Here, we mapped the pattern of pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa6a7b9a6d8e940c89960aa19fe382e
https://doi.org/10.1101/gad.277350.116