Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nat F Brown"'
Autor:
Nichollas E Scott, Lindsay D Rogers, Anna Prudova, Nat F Brown, Nikolaus Fortelny, Christopher M Overall, Leonard J Foster
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 1, Pp n/a-n/a (2017)
Abstract Protein–protein interaction networks (interactomes) define the functionality of all biological systems. In apoptosis, proteolysis by caspases is thought to initiate disassembly of protein complexes and cell death. Here we used a quantitati
Externí odkaz:
https://doaj.org/article/187af0e84048468aae83b41f8e049a42
Autor:
Amit P Bhavsar, Nat F Brown, Jan Stoepel, Marcel Wiermer, Dale D O Martin, Karolynn J Hsu, Koshi Imami, Colin J Ross, Michael R Hayden, Leonard J Foster, Xin Li, Phil Hieter, B Brett Finlay
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003518 (2013)
To further its pathogenesis, S. Typhimurium delivers effector proteins into host cells, including the novel E3 ubiquitin ligase (NEL) effector SspH2. Using model systems in a cross-kingdom approach we gained further insight into the molecular functio
Externí odkaz:
https://doaj.org/article/18d8300ef9bc4b3f815eb0cf4287600f
Autor:
Nat F Brown, Brian K Coombes, Jenna L Bishop, Mark E Wickham, Michael J Lowden, Ohad Gal-Mor, David L Goode, Erin C Boyle, Kristy L Sanderson, B Brett Finlay
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17824 (2011)
Salmonella enterica is a species of bacteria that is a major cause of enteritis across the globe, while certain serovars cause typhoid, a more serious disease associated with a significant mortality rate. Type III secreted effectors are major contrib
Externí odkaz:
https://doaj.org/article/66f28c5d604040d3a949c89911dabd5c
Publikováno v:
PLoS Pathogens, Vol 2, Iss 5, p e42 (2006)
The evolution of pathogens presents a paradox. Pathogenic species are often absolutely dependent on their host species for their propagation through evolutionary time, yet the pathogenic lifestyle requires that the host be damaged during this depende
Externí odkaz:
https://doaj.org/article/e1c324652f4b4f9ea9fe9f900f889dad
Publikováno v:
PLoS Pathogens, Vol 1, Iss 3, p e32 (2005)
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that causes disease in mice that resembles human typhoid. Typhoid pathogenesis consists of distinct phases in the intestine and a subsequent systemic phase in which bacte
Externí odkaz:
https://doaj.org/article/6404362f505744e0b24bc50401897498
Autor:
Nat F. Brown, Anna Prudova, Christopher M. Overall, Nikolaus Fortelny, Leonard J. Foster, Lindsay D. Rogers, Nichollas E. Scott
Publikováno v:
Molecular Systems Biology
Protein–protein interaction networks (interactomes) define the functionality of all biological systems. In apoptosis, proteolysis by caspases is thought to initiate disassembly of protein complexes and cell death. Here we used a quantitative proteo
Autor:
Nat F. Brown, B. Brett Finlay
Publikováno v:
Mobile Genetic Elements. 1:118-121
A major virulence mechanism used by pathogenic Gram-negative bacteria is the delivery of effector proteins from the bacterial cytoplasm into host cells by type III secretion. Typically, genes encoding type III secretion systems (T3SS) and effectors h
Publikováno v:
Proceedings of the National Academy of Sciences. 102:17460-17465
Salmonella enterica relies on a type III secretion system encoded in Salmonella pathogenicity island-2 (SPI-2) to survive and replicate within macrophages at systemic sites during typhoid. SPI-2 virulence is induced upon entry into macrophages, but t
Publikováno v:
Journal of Biological Chemistry. 279:49804-49815
Salmonella pathogenicity island (SPI)-2 is pivotal to the intracellular survival of Salmonella and for virulence in mammals. SPI-2 encodes virulence factors (called effectors) that are translocated into the host cell, a type III secretion apparatus a
Autor:
Joost W. Gouw, Elizabeth L. Hartland, Nat F. Brown, Leonard J. Foster, Kristy L Sanderson, Lindsay D. Rogers
Publikováno v:
mBio
mBio, Vol 5, Iss 5 (2014)
mBio, Vol 5, Iss 5 (2014)
The transcription factors HilA and SsrB activate expression of two type III secretion systems (T3SSs) and cognate effectors that reprogram host cell functions to benefit infecting Salmonella in the host. These transcription factors, the secretion sys