Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Natércia F. Brás"'
Autor:
Maria P. Silva, Luísa T. Ferreira, Natércia F. Brás, Lurdes Torres, Andreia Brandão, Manuela Pinheiro, Marta Cardoso, Adriana Resende, Joana Vieira, Carlos Palmeira, Gabriela Martins, Miguel Silva, Carla Pinto, Ana Peixoto, João Silva, Rui Henrique, Sofia Maia, Helder Maiato, Manuel R. Teixeira, Paula Paulo
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-17 (2024)
Abstract Background Prostate cancer (PrCa) is the most frequently diagnosed cancer in men. Variants in known moderate- to high-penetrance genes explain less than 5% of the cases arising at early-onset (
Externí odkaz:
https://doaj.org/article/89556ac24efa46d1a230f329bd5bf87d
Autor:
Shailendra Singh, Subarno Paul, Chandrabose Karthikeyan, Natércia F. Brás, Chanakya Nath Kundu, Narayana Subbiah Hari Narayana Moorthy
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 117 (2022)
FASN is a metabolic oncoprotein that is overexpressed in multiple cancers and regulates the fatty acid requirements of proliferating cells. Thus, FASN has been proposed as a promising target for anticancer drug discovery. Herein, we report the de nov
Externí odkaz:
https://doaj.org/article/6e39b6da76b54549aebde68ab53dde58
Autor:
Patrícia Correia, Hélder Oliveira, Paula Araújo, Natércia F. Brás, Ana Rita Pereira, Joana Moreira, Victor de Freitas, Nuno Mateus, Joana Oliveira, Iva Fernandes
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6192 (2021)
Tyrosinase is the central enzyme involved in the highly complex process of melanin formation, catalyzing the rate-limiting steps of this biosynthetic pathway. Due to such a preponderant role, it has become a major target in the treatment of undesired
Externí odkaz:
https://doaj.org/article/0ddc4bceb9ed47978823e9f4944a6952
Autor:
Patrícia Correia, Paula Araújo, Carolina Ribeiro, Hélder Oliveira, Ana Rita Pereira, Nuno Mateus, Victor de Freitas, Natércia F. Brás, Paula Gameiro, Patrícia Coelho, Lucinda J. Bessa, Joana Oliveira, Iva Fernandes
Publikováno v:
Antioxidants, Vol 10, Iss 7, p 1038 (2021)
Human skin is commonly described as a particularly dynamic and complex environment, with a physiological balance continuously orchestrated by numerous internal and external factors. Intrinsic aging, exposure to UV radiation and skin pathogens are som
Externí odkaz:
https://doaj.org/article/fe62c72b84c64b3b97317514b9fd875a
Autor:
Hélder Oliveira, Ana Fernandes, Natércia F. Brás, Nuno Mateus, Victor de Freitas, Iva Fernandes
Publikováno v:
Molecules, Vol 25, Iss 17, p 3813 (2020)
Many efforts have been made in the past two decades into the search for novel natural and less-toxic anti-diabetic agents. Some clinical trials have assigned this ability to anthocyanins, although different factors like the food source, the amount in
Externí odkaz:
https://doaj.org/article/aebca7fb7e644e8caa97cc8eb45bb0b5
Autor:
André Seco, Nuno Basílio, Natércia F. Brás, Kumi Yoshida, Tadao Kondo, Kin-ichi Oyama, Fernando Pina
Publikováno v:
Journal of Agricultural and Food Chemistry. 70:11391-11400
Autor:
Bárbara Torres-Rochera, Elvira Manjón, Natércia F Brás, María Teresa Escribano-Bailón, Ignacio García-Estévez
Publikováno v:
Journal of Agricultural and Food Chemistry.
Autor:
Himani Sharma, Baddipadige Raju, Gera Narendra, Manoj Kumar, Himanshu Verma, Bhavna Sharma, Gurleen Kaur Tung, Subheet Kumar Jain, Natércia F. Brás, Om Silakari
Publikováno v:
Journal of molecular graphicsmodelling. 119
Cytochrome P4501B1 (CYP1B1) is reported to be overexpressed in various malignancies including ovarian, lung, lymph, and breast cancers. The overexpression of this enzyme is accountable for the biotransformation-based inactivation of some anti-cancer
Autor:
Dharmendra Kashyap, Natércia F. Brás, Deeksha Tiwari, N.S. Hari Narayana Moorthy, Manivannan Elangovan, Shweta Jakhmola, Rajesh Kumar, Hem Chandra Jha
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:10629-10650
Plants are a valued potential source of drugs for a variety of diseases and are often considered less toxic to humans. We investigated antiviral compounds that may potentially target SARS-CoV-2 antigenic spike (S) and host proteins; angiotensin-conve
Publikováno v:
Chemistry – A European Journal. 28
The oxidized form of baicalein (BA) leads to covalent binding with human amyloid proteins. Such adducts hamper the aggregation and deposition of fibrils. A novel reaction of BA with pentylamine (PA) as a model for the lysine side chain is described.