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Autor:
Rayne S. S. Magalhães, Fernanda C. Boechat, Aline A. Brasil, José. R. M. Neto, Gabriela D. Ribeiro, Luan H. Paranhos, Natália Neves de Souza, Tuane Vieira, Tiago F. Outeiro, Bianca C. Neves, Elis C. A. Eleutherio
Publikováno v:
Journal of cellular biochemistry 123(11), 1808-1816 (2022). doi:10.1002/jcb.30317
Cancer-related metabolic features are in part maintained by hexokinase 2 upregulation, which leads to high levels of glucose-6-phosphate (G6P) and is needed to provide energy and biomass to support rapid proliferation. Using a humanized model of the