Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Nasun Hah"'
Autor:
Gaoyang Liang, Tae Gyu Oh, Nasun Hah, Hervé Tiriac, Yu Shi, Morgan L. Truitt, Corina E. Antal, Annette R. Atkins, Yuwenbin Li, Cory Fraser, Serina Ng, Antonio F. M. Pinto, Dylan C. Nelson, Gabriela Estepa, Senada Bashi, Ester Banayo, Yang Dai, Christopher Liddle, Ruth T. Yu, Tony Hunter, Dannielle D. Engle, Haiyong Han, Daniel D. Von Hoff, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Oncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery in stromal components to establish a desmoplastic and therapeutic resistant tumor microenvironment (TME). Here we identify Class I histone deacetyla
Externí odkaz:
https://doaj.org/article/7cb7b07e6adf42b0aac1cff0935b9ca2
Autor:
Corina E. Antal, Tae Gyu Oh, Stefan Aigner, En-Ching Luo, Brian A. Yee, Tania Campos, Hervé Tiriac, Katherine L. Rothamel, Zhang Cheng, Henry Jiao, Allen Wang, Nasun Hah, Elizabeth Lenkiewicz, Jan C. Lumibao, Morgan L. Truitt, Gabriela Estepa, Ester Banayo, Senada Bashi, Edgar Esparza, Ruben M. Munoz, Jolene K. Diedrich, Nicole M. Sodir, Jasmine R. Mueller, Cory R. Fraser, Erkut Borazanci, David Propper, Daniel D. Von Hoff, Christopher Liddle, Ruth T. Yu, Annette R. Atkins, Haiyong Han, Andrew M. Lowy, Michael T. Barrett, Dannielle D. Engle, Gerard I. Evan, Gene W. Yeo, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core genes involved in cell-specific function, here we uncover a druggable SE
Externí odkaz:
https://doaj.org/article/57cc744cc0404cd39ed1bebee4e6eee7
Autor:
Maryam Ahmadian, Sihao Liu, Shannon M. Reilly, Nasun Hah, Weiwei Fan, Eiji Yoshihara, Pooja Jha, C. Daniel De Magalhaes Filho, Sandra Jacinto, Andrew V. Gomez, Yang Dai, Ruth T. Yu, Christopher Liddle, Annette R. Atkins, Johan Auwerx, Alan R. Saltiel, Michael Downes, Ronald M. Evans
Publikováno v:
Cell Reports, Vol 22, Iss 11, Pp 2849-2859 (2018)
Summary: Brown adipose tissue (BAT) adaptively transfers energy from glucose and fat into heat by inducing a gene network that uncouples mitochondrial electron transport. However, the innate transcription factors that enable the rapid adaptive respon
Externí odkaz:
https://doaj.org/article/db188ce91c5d4a32be3ccb91d3f63eb7
Autor:
Weiwei Fan, Nanhai He, Chun Shi Lin, Zong Wei, Nasun Hah, Wanda Waizenegger, Ming-Xiao He, Christopher Liddle, Ruth T. Yu, Annette R. Atkins, Michael Downes, Ronald M. Evans
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2521-2529 (2018)
Summary: PGC1α is a pleiotropic co-factor that affects angiogenesis, mitochondrial biogenesis, and oxidative muscle remodeling via its association with multiple transcription factors, including the master oxidative nuclear receptor ERRγ. To deciphe
Externí odkaz:
https://doaj.org/article/1fbeca72717d44df9a8fef8211ea3626
Autor:
Maria C Marchetto, Branka Hrvoj-Mihic, Bilal E Kerman, Diana X Yu, Krishna C Vadodaria, Sara B Linker, Iñigo Narvaiza, Renata Santos, Ahmet M Denli, Ana PD Mendes, Ruth Oefner, Jonathan Cook, Lauren McHenry, Jaeson M Grasmick, Kelly Heard, Callie Fredlender, Lynne Randolph-Moore, Rijul Kshirsagar, Rea Xenitopoulos, Grace Chou, Nasun Hah, Alysson R Muotri, Krishnan Padmanabhan, Katerina Semendeferi, Fred H Gage
Publikováno v:
eLife, Vol 8 (2019)
Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often does not recapitulate importa
Externí odkaz:
https://doaj.org/article/8eb5b01f74684625be3abe311de8e7dd
Autor:
Nazma Malik, Bibiana I. Ferreira, Pablo E. Hollstein, Stephanie D. Curtis, Elijah Trefts, Sammy Weiser Novak, Jingting Yu, Rebecca Gilson, Kristina Hellberg, Lingjing Fang, Arlo Sheridan, Nasun Hah, Gerald S. Shadel, Uri Manor, Reuben J. Shaw
Publikováno v:
Science. 380
Cells respond to mitochondrial poisons with rapid activation of the adenosine monophosphate–activated protein kinase (AMPK), causing acute metabolic changes through phosphorylation and prolonged adaptation of metabolism through transcriptional effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c60372c6d0433474cdd1b48556a27a96
https://doi.org/10.1126/science.abj5559
https://doi.org/10.1126/science.abj5559
Autor:
Greg Lemke, Patrick Burrola, Kaisa E. Happonen, Nasun Hah, Youtong Huang, Ling Huang, Axel Nimmerjahn, Carolyn O’Connor
Publikováno v:
Nature immunology
Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer’s disease, but their roles in disease have not been tested experimentally. We find that in Alzheimer’s disease and its mouse models, induced expression of Ax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee20c04f15cc8b45604686200c8c4ad3
http://europepmc.org/articles/PMC8102389
http://europepmc.org/articles/PMC8102389
Autor:
Nasiha S. Ahmed, Jovylyn Gatchalian, Josephine Ho, Mannix J. Burns, Nasun Hah, Zong Wei, Michael Downes, Ronald M. Evans, Diana C. Hargreaves
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 1
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Macrophages regulate many aspects of the innate immune response and the activation of adaptive immunity following exposure to microbial ligands. However, macrophages can also contribute to inflammation underlying diseases such as atheros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7282207e323c9fe2517a667078ba4bf4
https://escholarship.org/uc/item/4qq4k8j6
https://escholarship.org/uc/item/4qq4k8j6
Autor:
Gerald S. Shadel, W. Travis Berggren, Maxim N Shokriev, Uri Manor, Kurt Marek, Stefania Zambetti, David D. O'Keefe, Anthony J.A. Molina, Kenneth E. Diffenderfer, Alessandra Sacco, Martin W. Hetzer, Peter D. Adams, Antonio Pinto, Nasun Hah, Tatyana O. Sharpee, Fred H. Gage, Malene Hansen, Jolene K. Diedrich
Publikováno v:
GeroScience, vol 43, iss 5
GeroScience
GeroScience
Understanding basic mechanisms of aging holds great promise for developing interventions that prevent or delay many age-related declines and diseases simultaneously to increase human healthspan. However, a major confounding factor in aging research i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b41a121eaa93820b3d520a3054efbbb
https://escholarship.org/uc/item/6cs470ht
https://escholarship.org/uc/item/6cs470ht
Autor:
Steve Horvath, Simon T. Schafer, Dylan A. Reid, Ake T. Lu, Fred H. Gage, Christopher K. Glass, Patrick J. Reed, Grace Chou, Claire A. McClain, Jeffrey R. Jones, Jesse R. Dixon, Sahaana Chandran, Addison J. Lana, Anthony S. Ricciardulli, Enoch C. Tsui, Ioana I. Nitulescu, Tzu-Wen Wang, Jean H. Ooi, Shong Lau, Johannes C. M. Schlachetzki, Nasun Hah, Sara B. Linker
Publikováno v:
Science (New York, N.Y.), vol 372, iss 6537
Science
Science
DNA repair within neurons Humans have only a limited capacity to generate new neurons. These cells thus need to repair errors in the genome. To better understand this process, Reid et al. developed Repair-seq, a method to locate DNA repair within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d60dd82faff91dff991ec21a36ff828
https://escholarship.org/uc/item/5px9q677
https://escholarship.org/uc/item/5px9q677