Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nastasja Merle"'
Autor:
Evangelos Pavlakis, Michelle Neumann, Nastasja Merle, Ronja Wieboldt, Michael Wanzel, Viviane Ponath, Elke Pogge von Strandmann, Sabrina Elmshäuser, Thorsten Stiewe
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-21 (2023)
Abstract Background TP53, encoding the tumor suppressor p53, is frequently mutated in various cancers, producing mutant p53 proteins (mutp53) which can exhibit neomorphic, gain-of-function properties. The latter transform p53 into an oncoprotein that
Externí odkaz:
https://doaj.org/article/4196caed645b473fadaf09c6ecb0eca3
Autor:
Nastasja Merle, Sabrina Elmshäuser, Florian Strassheimer, Michael Wanzel, Alexander M. König, Julianne Funk, Michelle Neumann, Katharina Kochhan, Frederik Helmprobst, Axel Pagenstecher, Andrea Nist, Marco Mernberger, André Schneider, Thomas Braun, Tilman Borggrefe, Rajkumar Savai, Oleg Timofeev, Thorsten Stiewe
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-22 (2022)
Abstract Background In vivo gene editing of somatic cells with CRISPR nucleases has facilitated the generation of autochthonous mouse tumors, which are initiated by genetic alterations relevant to the human disease and progress along a natural timeli
Externí odkaz:
https://doaj.org/article/d980d18d5f1b484f966f534df0c944fb
Autor:
Boris Klimovich, Laura Meyer, Nastasja Merle, Michelle Neumann, Alexander M. König, Nikolaos Ananikidis, Corinna U. Keber, Sabrina Elmshäuser, Oleg Timofeev, Thorsten Stiewe
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-18 (2022)
Abstract Background Impaired p53 function is one of the central molecular features of a tumor cell and even a partial reduction in p53 activity can increase the cancer risk in mice and men. From a therapeutic perspective it is noteworthy that tumor c
Externí odkaz:
https://doaj.org/article/a5fc0464584d420f93f35003a2b8b8ba
Autor:
Tim Hundertmark, Sabrina Kreutz, Nastasja Merle, Andrea Nist, Boris Lamp, Thorsten Stiewe, Alexander Brehm, Renate Renkawitz-Pohl, Christina Rathke
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213177 (2019)
Spermatogenesis in Drosophila melanogaster is characterized by a specific transcriptional program during the spermatocyte stage. Transcription of thousands of genes is regulated by the interaction of several proteins or complexes, including a tTAF-co
Externí odkaz:
https://doaj.org/article/cc0199d79e9f4f5c9afca26deb3b2954
Autor:
Julianne Funk, Maria Klimovich, Evangelos Pavlakis, Michelle Neumann, Daniel Drangenstein, Maxim Noeparast, Pascal Hunold, Anna Borowek, Dimitrios-Ilias Balourdas, Katharina Kochhan, Nastasja Merle, Imke Bullwinkel, Michael Wanzel, Sabrina Elmshäuser, Andrea Nist, Tara Procida, Marek Bartkuhn, Katharina Humpert, Marco Mernberger, Rajkumar Savai, Andreas C. Joerger, Thorsten Stiewe
The tumor suppressor geneTP53is the most frequently mutated gene in various cancers. Unlike other tumor suppressors,TP53is mostly hit by missense mutations, of which more than 2,000 have been described in cancer patients. To take advantage ofTP53muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bd897fd30da296ebc5a45f07280c622
https://doi.org/10.1101/2023.03.10.531074
https://doi.org/10.1101/2023.03.10.531074
Autor:
Boris Klimovich, Nastasja Merle, Michelle Neumann, Sabrina Elmshäuser, Andrea Nist, Marco Mernberger, Daniel Kazdal, Albrecht Stenzinger, Oleg Timofeev, Thorsten Stiewe
Publikováno v:
Oncogene. 41:1011-1023
The tumor suppressive transcription factor p53 is frequently inactivated in cancer cells by missense mutations that cluster in the DNA binding domain. 30% hit mutational hotspot residues, resulting in a complete loss of transcriptional activity and m
Autor:
Boris Klimovich, Laura Meyer, Nastasja Merle, Michelle Neumann, Alexander M. König, Nikolaos Ananikidis, Corinna U. Keber, Sabrina Elmshäuser, Oleg Timofeev, Thorsten Stiewe
Publikováno v:
Journal of experimentalclinical cancer research : CR. 41(1)
Background Impaired p53 function is one of the central molecular features of a tumor cell and even a partial reduction in p53 activity can increase the cancer risk in mice and men. From a therapeutic perspective it is noteworthy that tumor cells ofte