Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nastaran Daneshgar"'
Autor:
Nastaran Daneshgar, Mariah R. Leidinger, Stephanie Le, Marco Hefti, Alessandro Prigione, Dao-Fu Dai
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2023)
Neuroinflammation is one of the main mechanisms leading to neuronal death and dysfunction in neurodegenerative diseases. The role of microglia as primary mediators of inflammation is unclear in Leigh syndrome (LS) patients. This study aims to elucida
Externí odkaz:
https://doaj.org/article/dab6a427d3854ac5848e9afe3e7fecc0
Autor:
Nastaran Daneshgar, Andrew W. Baguley, Peir-In Liang, Fei Wu, Yi Chu, Michael T. Kinter, Gloria A. Benavides, Michelle S. Johnson, Victor Darley-Usmar, Jianhua Zhang, Kung-Sik Chan, Dao-Fu Dai
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Daneshgar et al. investigated the role of mitochondrial dysfunction in ADPKD and mitochondria protective agents as potential therapeutics. The authors reported decreased mitochondrial complex activity and downregulation of mitochondrial and metabolic
Externí odkaz:
https://doaj.org/article/1d0d0cfe52ff48c79a03d8870143777f
Autor:
Jin‐Young Yoon, Nastaran Daneshgar, Yi Chu, Biyi Chen, Marco Hefti, Ajit Vikram, Kaikobad Irani, Long‐Sheng Song, Charles Brenner, E. Dale Abel, Barry London, Dao‐Fu Dai
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)
Abstract Background Mice with deletion of complex I subunit Ndufs4 develop mitochondrial encephalomyopathy resembling Leigh syndrome (LS). The metabolic derangement and underlying mechanisms of cardio‐encephalomyopathy in LS remains incompletely un
Externí odkaz:
https://doaj.org/article/9fc05873d4fb4a8a92652c0c9b8bc8e0
Mitochondrial Oxidative Stress Mediates Bradyarrhythmia in Leigh Syndrome Mitochondrial Disease Mice
Publikováno v:
Antioxidants, Vol 12, Iss 5, p 1001 (2023)
Mitochondrial oxidative stress has been implicated in aging and several cardiovascular diseases, including heart failure and cardiomyopathy, ventricular tachycardia, and atrial fibrillation. The role of mitochondrial oxidative stress in bradyarrhythm
Externí odkaz:
https://doaj.org/article/8e4b40a50edc4900ac77f531c508131f
Autor:
Nastaran Daneshgar, Peir-In Liang, Christina J. Michels, Carla M. Nester, Lyndsay A. Harshman, Dao-Fu Dai
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Coronavirus disease 2019 (COVID-19) may cause a wide spectrum of kidney pathologies. The impact of COVID-19 is unclear in the context of the complement system abnormalities, including C3 glomerulopathy (C3G). In this report, we describe a young adult
Externí odkaz:
https://doaj.org/article/79a9c6c77aff45cb8f91c34968d68770
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 168 (2021)
Mechanistic Target of Rapamycin (mTOR) signaling is a key regulator of cellular metabolism, integrating nutrient sensing with cell growth. Over the past two decades, studies on the mTOR pathway have revealed that mTOR complex 1 controls life span, he
Externí odkaz:
https://doaj.org/article/f3a64f891bb944719af0257f2e7097dc
Autor:
Jin-Young Yoon, Nastaran Daneshgar, Yi Chu, Biyi Chen, Marco Hefti, Kaikobad Irani, Long-Sheng Song, Charles Brenner, E. Dale Abel, Barry London, Dao-Fu Dai
Mice with deletion of complex I subunit Ndufs4 develop mitochondrial encephalomyopathy resembling Leigh syndrome (LS). We report that LS mice also develop severe cardiac bradyarrhythmia and diastolic dysfunction. Human induced pluripotent stem cell-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0bf0128bf8b35e90597b7c37ecb6d63
https://doi.org/10.1101/2022.01.04.475008
https://doi.org/10.1101/2022.01.04.475008
Autor:
Dao-Fu Dai, Yi Chu, Gloria A. Benavides, Michelle S. Johnson, Kung-Sik Chan, Victor M. Darley-Usmar, Fei Wu, Nastaran Daneshgar, Peir-In Liang, Michael Kinter, Andrew W. Baguley, Jianhua Zhang
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressively enlarging cysts. Here we elucidate the interplay between oxidative stress, mitochondrial dysfunction, and metabolic derangement using two mouse models of PKD1 muta
Autor:
Nastaran Daneshgar, Peir-In Liang, Renny S. Lan, McKenna M. Horstmann, Lindsay Pack, Gourav Bhardwaj, Christie M. Penniman, Brian T. O’Neill, Dao-Fu Dai
Publikováno v:
Kidney Int
Pregnancy is proposed to aggravate cyst progression in autosomal dominant polycystic kidney disease (ADPKD) but Tolvaptan, the only FDA-approved drug for adult ADPKD, is not recommended for pregnant ADPKD patients because of potential fetal harm. Sin
Publikováno v:
International Journal of Pediatrics, Vol 6, Iss 12, Pp 8675-8684 (2018)
Background Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are among the most severe dermatologic reactions to the drugs. Data about SJS and TEN among pediatric population especially in Iran is limited. This study aimed to investi