Comprehensive analysis of the specificity of transcription activator-like effector nucleases

Autor: Guillermo Montoya, Stéphanie Langevin, Philippe Duchateau, George H. Silva, Stefano Stella, Nassima Benomari, Fayza Daboussi, Alexandre Juillerat, Aymeric Duclert, Julien Valton, Gwendoline Dubois, Jean-Charles Epinat, Alan Maréchal, Séverine Thomas, Claudia Bertonati

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2014, 42 (8), pp.5390-5402. ⟨10.1093/nar/gku155⟩
Nucleic Acids Research 8 (42), 5390-5402. (2014)

A key issue when designing and using DNA-targeting nucleases is specificity. Ideally, an optimal DNA-targeting tool has only one recognition site within a genomic sequence. In practice, however, almost all designer nucleases available today can accom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3079a1446b7cbbe4e72dda0af5ee5744
https://pubmed.ncbi.nlm.nih.gov/24569350