Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nasser Alotaiq"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10818 (2024)
Suppressor of cytokine signaling 2 (SOCS2), an E3 ubiquitin ligase, regulates the JAK/STAT signaling pathway, essential for cytokine signaling and immune responses. Its dysregulation contributes to cardiovascular diseases (CVDs) by promoting abnormal
Externí odkaz:
https://doaj.org/article/0f791ef05891473cbe6a4265179bd6c8
Autor:
Jamie J. L. Williams, Nasser Alotaiq, William Mullen, Richard Burchmore, Libin Liu, George S. Baillie, Fred Schaper, Paul F. Pilch, Timothy M. Palmer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
SOCS3 is an important negative feedback inhibitor of JAK–STAT-mediated cytokine signalling. Here the authors implicate cavin-1 — an essential component of caveolae — in the recruitment of SOCS3 to the plasma membrane to prevent sustained cytoki
Externí odkaz:
https://doaj.org/article/150955b131d248018bd4158e8688ea0e
Autor:
Libin Liu, William Mullen, Fred Schaper, Jamie J.L. Williams, Timothy M. Palmer, George S. Baillie, Nasser Alotaiq, Paul F. Pilch, Richard Burchmore
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Effective suppression of JAK–STAT signalling by the inducible inhibitor “suppressor of cytokine signalling 3” (SOCS3) is essential for limiting signalling from cytokine receptors. Here we show that cavin-1, a component of caveolae, is a functio
Publikováno v:
Heart. 103:A140.2-A140
Caveolae are lipid raft microdomains essential for the compartmentalisation and regulation of several signalling pathways e.g. JAK/STAT signalling. Disruption of caveolae is a significant factor in multiple disorders including muscular dystrophy, car
Publikováno v:
Heart. 100:A6.1-A6
Caveolae are plasma membrane microdomains that localise receptors and signalling intermediates within an environment where they can efficiently trigger downstream events. While present in most cells types, they are particularly abundant in vascular s