Cross‐talk between motor neurons and myotubes via endogenously secreted neural and muscular growth factors

Autor: Jasdeep Saini, Alessandro Faroni, Adam J. Reid, Vincent Mouly, Gillian Butler‐Browne, Adam P. Lightfoot, Jamie S. McPhee, Hans Degens, Nasser Al‐Shanti

Publikováno v: Physiological Reports, Vol 9, Iss 8, Pp n/a-n/a (2021)

Abstract Neuromuscular junction (NMJ) research is vital to advance the understanding of neuromuscular patho‐physiology and development of novel therapies for diseases associated with NM dysfunction. In vivo, the micro‐environment surrounding the

Externí odkaz: https://doaj.org/article/9b0c36e3dc4045a0a5f6b1905a081b1f

Activated Lymphocytes Secretome Inhibits Differentiation and Induces Proliferation of C2C12 Myoblasts

Autor: Nasser Al-Shanti, Peter Durcan, Sarah Al-Dabbagh, Georgi A. Dimchev, Claire E. Stewart

Publikováno v: Cellular Physiology and Biochemistry, Vol 33, Iss 1, Pp 117-128 (2014)

Background/Aims: ageing is associated with a marked decline in immune function which may contribute to the local environment that can influence the regenerative process of skeletal muscle cells. Methods: Herein, we focused on determining the effect o

Externí odkaz: https://doaj.org/article/6dab1d746d1c49b8b5a0a16fb435da87

A Novel Bioengineered Functional Motor Unit Platform to Study Neuromuscular Interaction

Autor: Adam P. Lightfoot, Kamel Mamchaoui, Adam J Reid, Hans Degens, Jasdeep Saini, Nasser Al-Shanti, Gillian Butler-Browne, Jamie S. McPhee, Alessandro Faroni, Vincent Mouly

Publikováno v: Journal of Clinical Medicine
Journal of Clinical Medicine, MDPI, 2020, 9 (10), pp.3238. ⟨10.3390/jcm9103238⟩
Journal of Clinical Medicine, Vol 9, Iss 3238, p 3238 (2020)
Journal of Clinical Medicine, MDPI, 2020, 9, ⟨10.3390/jcm9103238⟩
Volume 9
Issue 10
Journal of Clinical Medicine, 2020, 9 (10), pp.3238. ⟨10.3390/jcm9103238⟩

Background: In many neurodegenerative and muscular disorders, and loss of innervation in sarcopenia, improper reinnervation of muscle and dysfunction of the motor unit (MU) are key pathogenic features. In vivo studies of MUs are constrained due to di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ad1570a40003b3d04caa74b4e67242
https://e-space.mmu.ac.uk/626831/

Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance

Autor: Jean-Yves Hogrel, Gillian Butler-Browne, Liam Bagley, Steven Bradburn, Nasser Al-Shanti, Chris Murgatroyd, David M. A. Mann, Neil Pendleton, Marco Narici, Mati Pääsuke, Andrew C Robinson, Yoann Barnouin, Michael C. Carroll, Antony Payton, Helena Gapeyeva, Sarianna Sipilä, Mark Slevin, Jamie S. McPhee, Andrea B. Maier

Publikováno v: Neurobiology of Aging
Neurobiology of Aging, 2017, 63, pp.54-64. ⟨10.1016/j.neurobiolaging.2017.11.009⟩
Bradburn, S, McPhee, J, Bagley, L, Carroll, M, Slevin, M, Al-Shanti, N, Barnouin, Y, Hogrel, J-Y, Pääsuke, M, Gapeyeva, H, Maier, A, Sipilä, S, Narici, M, Robinson, A, Mann, D, Payton, A, Pendleton, N, Butler-Browne, G & Murgatroyd, C 2018, ' Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance ', Neurobiology of Aging, vol. 63, pp. 54-64 . https://doi.org/10.1016/j.neurobiolaging.2017.11.009
Neurobiology of Aging, Elsevier, 2017, 63, pp.54-64. ⟨10.1016/j.neurobiolaging.2017.11.009⟩
Neurobiology of Aging, 63, 54-64. Elsevier Inc.

International audience; Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5b6f921af550b5b225fafb0ce1cc8a
https://doi.org/10.1016/j.neurobiolaging.2017.11.009

Regenerative function of immune system: Modulation of muscle stem cells

Autor: Nasser Al-Shanti, Jasdeep Saini, Claire E. Stewart, Jamie S. McPhee, Sarah Al-Dabbagh

Publikováno v: Europe PubMed Central

Ageing is characterised by progressive deterioration of physiological systems and the loss of skeletal muscle mass is one of the most recognisable, leading to muscle weakness and mobility impairments. This review highlights interactions between the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cb95e9e7d17a20a0c10a68bd36bc04
https://doi.org/10.1016/j.arr.2016.03.006