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Akademický článek

Plasmodium RNA triphosphatase validation as antimalarial target.

Autor: Moliner-Cubel S; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain., Bahamontes-Rosa N; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain., Rodriguez-Alejandre A; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain., Nassau PM; Department of Biological Sciences, GlaxoSmithKline, Stevenage, SG2 7NY, UK., Argyrou A; Department of Biological Sciences, GlaxoSmithKline, Stevenage, SG2 7NY, UK., Bhardwaja A; Department of Biological Sciences, GlaxoSmithKline, Stevenage, SG2 7NY, UK., Buxton RC; Department of Biological Sciences, GlaxoSmithKline, Stevenage, SG2 7NY, UK., Calvo-Vicente D; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain., Mouzon B; Department of Biological Sciences, GlaxoSmithKline, Stevenage, SG2 7NY, UK., McDowell W; Department of Biological Sciences, GlaxoSmithKline, Stevenage, SG2 7NY, UK., Mendoza-Losana A; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain., Gomez-Lorenzo MG; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain. Electronic address: maria.g.gomez@gsk.com.

Publikováno v: International journal for parasitology. Drugs and drug resistance [Int J Parasitol Drugs Drug Resist] 2024 Aug; Vol. 25, pp. 100537. Date of Electronic Publication: 2024 Apr 26.

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Akademický článek

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

Autor: Harris PA, Faucher N; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., George N; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Eidam PM, King BW, White GV; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Anderson NA; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Bandyopadhyay D, Beal AM, Beneton V; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Berger SB, Campobasso N, Campos S; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Capriotti CA, Cox JA, Daugan A; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Donche F; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Fouchet MH; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Finger JN, Geddes B, Gough PJ, Grondin P; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Hoffman BL, Hoffman SJ, Hutchinson SE; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Jeong JU, Jigorel E; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Lamoureux P; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Leister LK, Lich JD, Mahajan MK, Meslamani J, Mosley JE; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Nagilla R, Nassau PM; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Ng SL, Ouellette MT, Pasikanti KK, Potvain F; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Reilly MA, Rivera EJ, Sautet S; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Schaeffer MC, Sehon CA, Sun H, Thorpe JH; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Totoritis RD, Ward P, Wellaway N; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Wisnoski DD, Woolven JM; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Bertin J, Marquis RW

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 May 23; Vol. 62 (10), pp. 5096-5110. Date of Electronic Publication: 2019 May 02.

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Akademický článek

Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates.

Autor: Li X; Anacor Pharmaceuticals, Inc., 1020 E. Meadow Circle, Palo Alto, CA 94303, USA., Zhang YK, Liu Y, Ding CZ, Zhou Y, Li Q, Plattner JJ, Baker SJ, Zhang S, Kazmierski WM, Wright LL, Smith GK, Grimes RM, Crosby RM, Creech KL, Carballo LH, Slater MJ, Jarvest RL, Thommes P, Hubbard JA, Convery MA, Nassau PM, McDowell W, Skarzynski TJ, Qian X, Fan D, Liao L, Ni ZJ, Pennicott LE, Zou W, Wright J

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Oct 01; Vol. 20 (19), pp. 5695-700. Date of Electronic Publication: 2010 Aug 10.

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