Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Nasrollah Rezaei‐Ghaleh"'
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract A complex interplay between various processes underlies the neuropathology of Alzheimer’s disease (AD) and its progressive course. Several lines of evidence point to the coupling between Aβ aggregation and neuroinflammation and its role i
Externí odkaz:
https://doaj.org/article/59860d9f1319420095994f8d230905ad
Autor:
Giuseppe Sicoli, Daniel Sieme, Kerstin Overkamp, Mahdi Khalil, Robin Backer, Christian Griesinger, Dieter Willbold, Nasrollah Rezaei-Ghaleh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Liquid-liquid phase separation is the key process underlying formation of membrane-less compartments in cells. A highly dynamic cellular body with rapid component exchange is Cajal body (CB), which supports the extensive compositional dynami
Externí odkaz:
https://doaj.org/article/bcc33a65d54749cc8fbd69a20d52e5f4
Autor:
Tina Ukmar-Godec, Saskia Hutten, Matthew P. Grieshop, Nasrollah Rezaei-Ghaleh, Maria-Sol Cima-Omori, Jacek Biernat, Eckhard Mandelkow, Johannes Söding, Dorothee Dormann, Markus Zweckstetter
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Processing bodies (P-bodies) are non-membrane-bound protein/RNA granules in the cytosol. Here the authors combine bioinformatics, NMR and cell based assays and find that lysine is enriched in the disordered regions of P-body-associated proteins and s
Externí odkaz:
https://doaj.org/article/ba5821511fba49e2bd2ace00270992df
Autor:
Ana Martinez Hernandez, Hendrik Urbanke, Alan L Gillman, Joon Lee, Sergey Ryazanov, Hope Y Agbemenyah, Eva Benito, Gaurav Jain, Lalit Kaurani, Gayane Grigorian, Andrei Leonov, Nasrollah Rezaei‐Ghaleh, Petra Wilken, Fernando Teran Arce, Jens Wagner, Martin Fuhrmann, Mario Caruana, Angelique Camilleri, Neville Vassallo, Markus Zweckstetter, Roland Benz, Armin Giese, Anja Schneider, Martin Korte, Ratnesh Lal, Christian Griesinger, Gregor Eichele, Andre Fischer
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 32-47 (2017)
Abstract Alzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcrip
Externí odkaz:
https://doaj.org/article/c508142ad7ed44dda436f67105c1fa85
Autor:
Nasrollah Rezaei-Ghaleh, Mehriar Amininasab, Sathish Kumar, Jochen Walter, Markus Zweckstetter
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Protein aggregation plays a crucial role in several neurodegenerative diseases. Here the authors demonstrate that phosphorylation of β-amyloid aggregates—the pathological hallmark of Alzheimer's disease—can change the molecular properties of agg
Externí odkaz:
https://doaj.org/article/b51e7f2b30e242a2be7281a13feadd10
Autor:
Francesca Munari, Nasrollah Rezaei-Ghaleh, Shengqi Xiang, Wolfgang Fischle, Markus Zweckstetter
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60887 (2013)
As essential components of the molecular machine assembling heterochromatin in eukaryotes, HP1 (Heterochromatin Protein 1) proteins are key regulators of genome function. While several high-resolution structures of the two globular regions of HP1, ch
Externí odkaz:
https://doaj.org/article/94f925db5f664815a27736b73ce193fd
Autor:
Nasrollah Rezaei-Ghaleh, Erika Andreetto, Li-Mei Yan, Aphrodite Kapurniotu, Markus Zweckstetter
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20289 (2011)
Assembly of amyloid-beta peptide (Aβ) into cytotoxic oligomeric and fibrillar aggregates is believed to be a major pathologic event in Alzheimer's disease (AD) and interfering with Aβ aggregation is an important strategy in the development of novel
Externí odkaz:
https://doaj.org/article/19dab0f40007472e8c5fa4c803f69293
Autor:
Mahdie Rahban, Samaneh Zolghadri, Najmeh Salehi, Faizan Ahmad, Thomas Haertlé, Nasrollah Rezaei-Ghaleh, Lindsay Sawyer, Ali Akbar Saboury
Publikováno v:
International Journal of Biological Macromolecules. 214:642-654
Increasing the temperature by just a few degrees may lead to structural perturbation or unfolding of the protein and consequent loss of function. The concepts of flexibility and rigidity are fundamental for understanding the relationships between fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecc85180baaa24ab31cfed76edd0dd1
https://doi.org/10.1016/j.ijbiomac.2022.06.154
https://doi.org/10.1016/j.ijbiomac.2022.06.154
Publikováno v:
Chemistry-a European journal 29(17), e202203493 (2023). doi:10.1002/chem.202203493
Chemistry – A European Journal
Chemistry – A European Journal
Reorientational dynamics of intrinsically disordered proteins (IDPs) contain multiple motions often clustered around three motional modes: ultrafast librational motions of amide groups, fast local backbone conformational fluctuations and slow chain s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d21782d0f5d28afafb69359745eef1
https://pubmed.ncbi.nlm.nih.gov/36579699
https://pubmed.ncbi.nlm.nih.gov/36579699
Autor:
Yasin Rafiei, Bahram Salmani, Behnaz Mirzaei-Behbahani, Mahshid Taleb, Ali Akbar Meratan, Mohammad Ramezani, Nasser Nikfarjam, Stefan Becker, Nasrollah Rezaei-Ghaleh
Publikováno v:
ACS chemical neuroscience. 13(22)
Natural compounds with anti-aggregation capacity are increasingly recognized as viable candidates against neurodegenerative diseases. Recently, the polyphenolic fraction of propolis (PFP), a complex bee product, has been shown to inhibit amyloid aggr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596a04f669daa9890ac8667871aa1493
https://pubmed.ncbi.nlm.nih.gov/36314062
https://pubmed.ncbi.nlm.nih.gov/36314062