Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Nasir Malik"'
Autor:
Marta Garcia-Montojo, Saeed Fathi, Cyrus Rastegar, Elena Rita Simula, Tara Doucet-O’Hare, Y. H. Hank Cheng, Rachel P. M. Abrams, Nicholas Pasternack, Nasir Malik, Muzna Bachani, Brianna Disanza, Dragan Maric, Myoung-Hwa Lee, Herui Wang, Ulisses Santamaria, Wenxue Li, Kevon Sampson, Juan Ramiro Lorenzo, Ignacio E. Sanchez, Alexandre Mezghrani, Yan Li, Leonardo Antonio Sechi, Sebastian Pineda, Myriam Heiman, Manolis Kellis, Joseph Steiner, Avindra Nath
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract TAR DNA-binding protein 43 (TDP-43) proteinopathy in brain cells is the hallmark of amyotrophic lateral sclerosis (ALS) but its cause remains elusive. Asparaginase-like-1 protein (ASRGL1) cleaves isoaspartates, which alter protein folding an
Externí odkaz:
https://doaj.org/article/3f8582a67a364758825325a7f9cb9801
Autor:
Brian Walitt, Komudi Singh, Samuel R. LaMunion, Mark Hallett, Steve Jacobson, Kong Chen, Yoshimi Enose-Akahata, Richard Apps, Jennifer J. Barb, Patrick Bedard, Robert J. Brychta, Ashura Williams Buckley, Peter D. Burbelo, Brice Calco, Brianna Cathay, Li Chen, Snigdha Chigurupati, Jinguo Chen, Foo Cheung, Lisa M. K. Chin, Benjamin W. Coleman, Amber B. Courville, Madeleine S. Deming, Bart Drinkard, Li Rebekah Feng, Luigi Ferrucci, Scott A. Gabel, Angelique Gavin, David S. Goldstein, Shahin Hassanzadeh, Sean C. Horan, Silvina G. Horovitz, Kory R. Johnson, Anita Jones Govan, Kristine M. Knutson, Joy D. Kreskow, Mark Levin, Jonathan J. Lyons, Nicholas Madian, Nasir Malik, Andrew L. Mammen, John A. McCulloch, Patrick M. McGurrin, Joshua D. Milner, Ruin Moaddel, Geoffrey A. Mueller, Amrita Mukherjee, Sandra Muñoz-Braceras, Gina Norato, Katherine Pak, Iago Pinal-Fernandez, Traian Popa, Lauren B. Reoma, Michael N. Sack, Farinaz Safavi, Leorey N. Saligan, Brian A. Sellers, Stephen Sinclair, Bryan Smith, Joseph Snow, Stacey Solin, Barbara J. Stussman, Giorgio Trinchieri, Sara A. Turner, C. Stephenie Vetter, Felipe Vial, Carlotta Vizioli, Ashley Williams, Shanna B. Yang, Center for Human Immunology, Autoimmunity, and Inflammation (CHI) Consortium, Avindra Nath
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)
Abstract Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used
Externí odkaz:
https://doaj.org/article/a14b918b7de649e6975c4ac14fdd7aa8
Autor:
Sevilla D. Detera-Wadleigh, Layla Kassem, Emily Besancon, Fabiana Lopes, Nirmala Akula, Heejong Sung, Meghan Blattner, Laura Sheridan, Ley Nadine Lacbawan, Joshua Garcia, Francis Gordovez, Katherine Hosey, Cassandra Donner, Claudio Salvini, Thomas Schulze, David T. W. Chen, Bryce England, Joanna Cross, Xueying Jiang, Winston Corona, Jill Russ, Barbara Mallon, Amalia Dutra, Evgenia Pak, Joe Steiner, Nasir Malik, Theresa de Guzman, Natia Horato, Mariana B. Mallmann, Victoria Mendes, Amanda L. Dűck, Antonio E. Nardi, Francis J. McMahon
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Genome-wide (GWAS) and copy number variant (CNV) association studies have reproducibly identified numerous risk alleles associated with bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ), but biological character
Externí odkaz:
https://doaj.org/article/fbb9f6f256a54082854ba103067d0d46
Autor:
Trevor Cerbini, Ray Funahashi, Yongquan Luo, Chengyu Liu, Kyeyoon Park, Mahendra Rao, Nasir Malik, Jizhong Zou
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116032 (2015)
Targeted genome engineering to robustly express transgenes is an essential methodology for stem cell-based research and therapy. Although designer nucleases have been used to drastically enhance gene editing efficiency, targeted addition and stable e
Externí odkaz:
https://doaj.org/article/b21b6fc0f50349bdb4f8c62e95c68605
Autor:
Nasir Malik, Xiantao Wang, Sonia Shah, Anastasia G Efthymiou, Bin Yan, Sabrina Heman-Ackah, Ming Zhan, Mahendra Rao
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96139 (2014)
Astrocytes are the most abundant cell type in the central nervous system (CNS) and have a multitude of functions that include maintenance of CNS homeostasis, trophic support of neurons, detoxification, and immune surveillance. It has only recently be
Externí odkaz:
https://doaj.org/article/ee7c380eedef486580b14bf3ce02f19f
Autor:
Altaf, Areeba, Jamil, Faisal, Yaqoob, Munazzah, Adnan Iqbal, Muhammad, Sadique, Shaheen, Manahil, Shaista, Nasir Malik, Shazia, Sohail Shoukat, Umar, khalid, Maria, Ullah Zia, Sami, Nadeem, Haris, Tauseef Haider, Mohammad
Publikováno v:
In Inorganica Chimica Acta 1 January 2025 574
Autor:
Yu Luo, Cameron H Good, Oscar Diaz-Ruiz, YaJun Zhang, Alexander F Hoffman, Lufei Shan, Serena Y Kuang, Nasir Malik, Vladimir I Chefer, Andreas C Tomac, Carl R Lupica, Cristina M Bäckman
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12141 (2010)
The initiation of behavioral sensitization to cocaine and other psychomotor stimulants is thought to reflect N-methyl-D-aspartate receptor (NMDAR)-mediated synaptic plasticity in the mesolimbic dopamine (DA) circuitry. The importance of drug induced
Externí odkaz:
https://doaj.org/article/6320367ff1ae43188ebccaaaa6504c2f
Autor:
Oscar Diaz-Ruiz, Agustin Zapata, Lufei Shan, YaJun Zhang, Andreas C Tomac, Nasir Malik, Fidel de la Cruz, Cristina M Bäckman
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7027 (2009)
The widespread distribution of the tumor suppressor PTEN in the nervous system suggests a role in a broad range of brain functions. PTEN negatively regulates the signaling pathways initiated by protein kinase B (Akt) thereby regulating signals for gr
Externí odkaz:
https://doaj.org/article/cbadc34e8d854ad0bd3099685c174ccf
Publikováno v:
Environmental Science and Pollution Research. 30:38886-38897
This article attempts to examine the role of creativity on carbon intensity in case of Organization of the Petroleum Exporting Countries (OPEC) countries. The panel estimation techniques are used for annual data for the period of 1990-2018. The empir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05337a270c1e12972f075cdc4efcc5c1
https://doi.org/10.1007/s11356-022-24903-8
https://doi.org/10.1007/s11356-022-24903-8
Autor:
Valerie Toodle, Myoung-Hwa Lee, Muzna Bachani, April Ruffin, Sneha Vivekanandhan, Nasir Malik, Tongguang Wang, Tory P. Johnson, Avindra Nath, Joseph P. Steiner
Publikováno v:
Neurotherapeutics. 19:1313-1328
There is a continuing unmet medical need to develop neuroprotective strategies to treat neurodegenerative disorders. To address this need, we screened over 2000 compounds for potential neuroprotective activity in a model of oxidative stress and found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48ef211f09328d0345159b253916e0e
https://doi.org/10.1007/s13311-022-01265-0
https://doi.org/10.1007/s13311-022-01265-0