Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Nasir K. Khan"'
Publikováno v:
Journal of Medical Primatology. 52:64-78
The cynomolgus macaque has become the most used non-human primate species in nonclinical safety assessment during the past decades.This review summarizes the biological data and organ system development milestones of the cynomolgus macaque available
Autor:
Aida I. Sacaan, Nasir K. Khan, Martin B. Finkelstein, Stephane Thibault, Bart A. Jessen, Tae Sung, Wenyue Hu
Supplementary references are listed for supplementary table S1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82650482f7204c3e6bee2eeabe11d01f
https://doi.org/10.1158/1078-0432.22460496
https://doi.org/10.1158/1078-0432.22460496
Autor:
Aida I. Sacaan, Nasir K. Khan, Martin B. Finkelstein, Stephane Thibault, Bart A. Jessen, Tae Sung, Wenyue Hu
Purpose: Palbociclib (PD-0332991) is the first selective cyclin-dependent kinase (CDK) 4/6 inhibitor approved for metastatic breast cancer. Hematologic effects, especially neutropenia, are dose-limiting adverse events for palbociclib in humans.Experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dfe797ed280ffcb0fb48869aadd6981
https://doi.org/10.1158/1078-0432.c.6524514
https://doi.org/10.1158/1078-0432.c.6524514
Autor:
Bernard S. Buetow, Magali Guffroy, Martin Finkelstein, Nasir K. Khan, Puja Sapra, Andrea T. Hooper, William A. Meier, Frank Barletta, Matthew Martin, Steven W. Kumpf, Sripad Ram, Allison Vitsky, Jonathan Golas, Marc D. Roy, Changhua Ji
Table S1. Mean ({plus minus}SD) Toxicokinetic Parameters for Ipilimumab and Novolumab in Cynomolgus Monkeys Table S2 - Differentially expressed genes in the heart of ipilimumab and nivolumab treated cynos (adjusted P-value {less than or equal to} 0.0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3942b4f23d29af0107356ea8a8bc653c
https://doi.org/10.1158/1078-0432.22469919.v1
https://doi.org/10.1158/1078-0432.22469919.v1
Autor:
Bernard S. Buetow, Magali Guffroy, Martin Finkelstein, Nasir K. Khan, Puja Sapra, Andrea T. Hooper, William A. Meier, Frank Barletta, Matthew Martin, Steven W. Kumpf, Sripad Ram, Allison Vitsky, Jonathan Golas, Marc D. Roy, Changhua Ji
Supplemental Figure S1. Concentration versus time profiles of ipilimumab and nivolumab following four weekly intravenous dose administrations of 15 mg/kg or 20 mg/kg, respectively. Supplementary Figure S2. Hematoxylin and eosin stained sections of ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027a7f5962acdd0744c93d4421f906a4
https://doi.org/10.1158/1078-0432.22469916
https://doi.org/10.1158/1078-0432.22469916
Autor:
Bernard S. Buetow, Magali Guffroy, Martin Finkelstein, Nasir K. Khan, Puja Sapra, Andrea T. Hooper, William A. Meier, Frank Barletta, Matthew Martin, Steven W. Kumpf, Sripad Ram, Allison Vitsky, Jonathan Golas, Marc D. Roy, Changhua Ji
Purpose:Immune checkpoint inhibitors (ICI) targeting PD1, PDL1, or CTLA4 are associated with immune-related adverse events (irAE) in multiple organ systems including myocarditis. The pathogenesis and early diagnostic markers for ICI-induced myocardit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5055934097852ef3af9d150157463861
https://doi.org/10.1158/1078-0432.c.6527388
https://doi.org/10.1158/1078-0432.c.6527388
Autor:
Aida I. Sacaan, Nasir K. Khan, Martin B. Finkelstein, Stephane Thibault, Bart A. Jessen, Tae Sung, Wenyue Hu
Supplementary Table S1-2. Table S1 - Clinical exposure for palbociclib, fulvestrant and chemotherapeutic agents used in this study. Table S2 - Cell cycle analysis in human bone marrow mononuclear cells treated with palbociclib for 4 days. Supplementa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be09a2743c601b1f49cea2592f3bfd0
https://doi.org/10.1158/1078-0432.22460502.v1
https://doi.org/10.1158/1078-0432.22460502.v1
Autor:
Aida I. Sacaan, Nasir K. Khan, Martin B. Finkelstein, Stephane Thibault, Bart A. Jessen, Tae Sung, Wenyue Hu
Supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10153633f952f70b4055cd6783a0d0a7
https://doi.org/10.1158/1078-0432.22460499
https://doi.org/10.1158/1078-0432.22460499
Autor:
Xiantang Li, Dingzhou Li, Kathleen E. Biddle, Susan S. Portugal, Mark R. Li, Rosemary Santos, John E. Burkhardt, Nasir K. Khan
Publikováno v:
Veterinary clinical pathology. 51(3)
Clinical pathology and body weight information for the cynomolgus monkey in the literature is primarily derived from a small number of animals with limited age ranges, varying geographic origins, and mixed genders.This study aimed to summarize the ag
Autor:
Allison Vitsky, Nasir K. Khan, Frank Barletta, Jonathan Golas, Changhua Ji, Steven W. Kumpf, Bernard S. Buetow, Andrea T. Hooper, Puja Sapra, Sripad Ram, Magali Guffroy, William A. Meier, Martin Finkelstein, Matthew Martin, Marc D. Roy
Publikováno v:
Clinical Cancer Research. 25:4735-4748
Purpose: Immune checkpoint inhibitors (ICI) targeting PD1, PDL1, or CTLA4 are associated with immune-related adverse events (irAE) in multiple organ systems including myocarditis. The pathogenesis and early diagnostic markers for ICI-induced myocardi