In-utero transfer of decidualized endometrial stromal cells increases the frequency of regulatory T cells and normalizes the abortion rate in the CBA/J × DBA/2 abortion model

Autor: Kayhan Zarnani, Kimia Zarnani, Nasim Maslehat-Lay, Bahman Zeynali, Sedigheh Vafaei, Mohammad-Reza Shokri, Negar Vanaki, Haleh Soltanghoraee, Ebrahim Mirzadegan, Haleh Edalatkhah, Mohammad-Mehdi Naderi, Ali Sarvari, Farnoosh Attari, Mahmood Jeddi-Tehrani, Amir-Hassan Zarnani

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionFailure to adequate decidualization leads to adverse pregnancy outcomes including pregnancy loss. Although there are plenty of reports underscoring immune dysfunction as the main cause of abortion in CBA/J females mated with DBA/2 males (

Externí odkaz: https://doaj.org/article/7df212f2df0b46769f633d2e407981d5

Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol

Autor: Alireza Fazeli, Nasim Maslehat Lay, Sarah Elliott, Michael R. H. White, James Boyd, Shaghayegh Basatvat, I. Caballero, Mehrnaz Montazeri, David G. Spiller, C. Almiñana, Javier A. Sánchez-López

Publikováno v: SCIENTIFIC REPORTS
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7, 10 p. ⟨10.1038/srep40981⟩
Scientific Reports, Nature Publishing Group, 2017, 7, pp.40981. ⟨10.1038/srep40981⟩
Scientific Reports (7), 40981. (2017)
Caballero, I, Boyd, J, Alminanã, C, Sánchez-López, J A, Basatvat, S, Montazeri, M, Maslehat Lay, N, Elliott, S, Spiller, D G, White, M R H & Fazeli, A 2017, ' Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol ', Scientific Reports, vol. 7, 40981 . https://doi.org/10.1038/srep40981

Toll-like receptors (TLRs) are major players of the innate immune system. Once activated, they trigger a signalling cascade that leads to NF-κB translocation from the cytoplasm to the nucleus. Single cell analysis shows that NF-κB signalling dynami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5e3dd0df3c81e347362932899b8624
http://livrepository.liverpool.ac.uk/3005586/1/tl5.pdf