Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nasim F Mehrabi"'
Autor:
Florence E. Layburn, Adelie Y.S. Tan, Nasim F. Mehrabi, Maurice A. Curtis, Lynette J. Tippett, Clinton P. Turner, Nathan Riguet, Lorène Aeschbach, Hilal A. Lashuel, Mike Dragunow, Richard L.M. Faull, Malvindar K. Singh-Bains
Publikováno v:
Neurobiology of Disease, Vol 174, Iss , Pp 105884- (2022)
Huntington's disease (HD) is caused by a CAG repeat expansion mutation in the gene encoding the huntingtin (Htt) protein, with mutant Htt protein subsequently forming aggregates within the brain. Mutant Htt is a current target for novel therapeutic s
Externí odkaz:
https://doaj.org/article/682f2366ef5b465c8aba8d90bd1270c5
Autor:
Pritika Narayan, Suzanne Reid, Emma L. Scotter, Ailsa L. McGregor, Nasim F. Mehrabi, Malvindar K. Singh-Bains, Michelle Glass, Richard L.M. Faull, Russell G. Snell, Mike Dragunow
Publikováno v:
Neurobiology of Disease, Vol 146, Iss , Pp 105092- (2020)
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in exon 1 of the huntingtin gene. Emerging evidence shows that additional epigenetic factors can modify disease phenotypes. Harnessing the abilit
Externí odkaz:
https://doaj.org/article/46c0279f44bc402698babefffb127715
Autor:
Malvindar K. Singh-Bains, Vanessa Linke, Micah D.R. Austria, Adelie Y.S. Tan, Emma L. Scotter, Nasim F. Mehrabi, Richard L.M. Faull, Mike Dragunow
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
Traditionally regarded to coordinate movement, the cerebellum also exerts non-motor functions including the regulation of cognitive and behavioral processing, suggesting a potential role in neurodegenerative conditions affecting cognition, such as Al
Externí odkaz:
https://doaj.org/article/7f5790f222104294a6230a6ef5b6e69f
Autor:
Nasim F. Mehrabi, PhD, Henry J. Waldvogel, PhD, Lynette J. Tippett, PhD, Virginia M. Hogg, MD, Beth J. Synek, MD, Richard L.M. Faull, MBChB, PhD, DSc
Publikováno v:
Neurobiology of Disease, Vol 96, Iss , Pp 67-74 (2016)
Background: Huntington's disease (HD) is characterised by variable symptoms and neuropathology of the basal ganglia and cortex. Previously, we have shown that the pattern of pyramidal cell loss in 8 different cortical regions correlates with the phen
Externí odkaz:
https://doaj.org/article/5cb8241a8c904a18b2dc48e3601178e6
Autor:
Florence E. Layburn, Adelie Y. S. Tan, Nasim F. Mehrabi, Maurice A. Curtis, Lynette J. Tippett, Nathan Riguet, Lorène Aeschbach, Hilal A. Lashuel, Mike Dragunow, Richard L. M. Faull, Malvindar K. Singh-Bains
Huntington’s disease (HD) is caused by a CAG repeat expansion mutation in the gene encoding the huntingtin (Htt) protein, with mutant Htt protein subsequently forming aggregates within the brain. Mutant Htt is a current target for novel therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::754ea9bcb712809b61a79184bb834350
https://doi.org/10.1101/2022.05.03.490349
https://doi.org/10.1101/2022.05.03.490349
Autor:
Richard L.M. Faull, Malvindar K. Singh-Bains, Nasim F. Mehrabi, Adelie Y. S. Tan, Mike Dragunow
Publikováno v:
Nature Protocols. 16:2308-2343
A major challenge in the treatment of neurodegenerative disorders is the translation of effective therapies from the lab to the clinic. One approach to improve this process is the use of human brain tissue microarray (HBTMA) technology to aid in the
Autor:
Tvesa Sehji, Lynette J. Tippett, Mike Dragunow, Richard L.M. Faull, Nasim F. Mehrabi, Henry J. Waldvogel, Adelie Y. S. Tan, Micah D. R. Austria, Malvindar K. Singh-Bains
Publikováno v:
Annals of Neurology
Objective Huntington disease (HD) is an autosomal dominant neurodegenerative disorder characterized by variable motor and behavioral symptoms attributed to major neuropathology of mainly the basal ganglia and cerebral cortex. The role of the cerebell
Autor:
Brigid Ryan, Blake Highet, Natacha Coppieters, Mike Dragunow, Birger Dieriks, Malvindar Singh-Bains, Richard L.M. Faull, Helen C. Murray, Praju Vikas Anekal, Nasim F Mehrabi, Maurice A. Curtis
Publikováno v:
Journal of neurochemistryReferences. 157(4)
In situ hybridization (ISH) is a powerful tool that can be used to localize mRNA expression in tissue samples. Combining ISH with immunohistochemistry (IHC) to determine cell type provides cellular context of mRNA expression, which cannot be achieved
Autor:
Malvindar K, Singh-Bains, Nasim F, Mehrabi, Adelie Y S, Tan, Richard L M, Faull, Mike, Dragunow
Publikováno v:
Nature protocols. 16(4)
A major challenge in the treatment of neurodegenerative disorders is the translation of effective therapies from the lab to the clinic. One approach to improve this process is the use of human brain tissue microarray (HBTMA) technology to aid in the
Autor:
Michelle Glass, Ailsa L. McGregor, Suzanne J. Reid, Russell G. Snell, Mike Dragunow, Malvindar K. Singh-Bains, Pritika Narayan, Emma L. Scotter, Nasim F. Mehrabi, Richard L.M. Faull
Publikováno v:
Neurobiology of Disease, Vol 146, Iss, Pp 105092-(2020)
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in exon 1 of the huntingtin gene. Emerging evidence shows that additional epigenetic factors can modify disease phenotypes. Harnessing the abilit