Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Nashaat, Turkman"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract The design and radiosynthesis of [18F]NT376, a high potency inhibitor of class-IIa histone deacetylases (HDAC) is reported. We utilized a three-step radiochemical approach that led to the radiosynthesis of [18F]NT376 in a good radiochemical
Externí odkaz:
https://doaj.org/article/f0bf006c95a3417281f3bdec699dc2a8
PEG2000-DBCO surface coating increases intracellular uptake of liposomes by breast cancer xenografts
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Given our interest in the utility of liposomes for molecular imaging and theranostics, we investigated how coating the outer layer of the liposome affects internalization by breast cancer cell lines in vitro and in breast tumor tissues in vi
Externí odkaz:
https://doaj.org/article/3a9dba3f7b2e4966970b0e7bed63895c
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Small molecules that contain the (TFMO) moiety were reported to specifically inhibit the class-IIa histone deacetylases (HDACs), an important target in cancer and the disorders of the central nervous system (CNS). However, radiolabeling meth
Externí odkaz:
https://doaj.org/article/116e1dae1af94700ab2521a3c43d920f
Publikováno v:
Journal of Medicinal Chemistry. 66:5611-5621
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc7bd04ff0287815c3b5994a19e3784c
https://doi.org/10.1021/acs.jmedchem.2c02064
https://doi.org/10.1021/acs.jmedchem.2c02064
Autor:
Kaixuan Li, Mingqian Wang, Melike Akoglu, Alyssa C. Pollard, John B. Klecker, Patricia Alfonso, Ana Corrionero, Niall Prendiville, Wenchao Qu, Matthew F. L. Parker, Nashaat Turkman, Jules A. Cohen, Peter J. Tonge
Publikováno v:
ACS Pharmacology & Translational Science. 6:410-421
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e285ee6662089e83d96073531199b63
https://doi.org/10.1021/acsptsci.2c00215
https://doi.org/10.1021/acsptsci.2c00215
We utilized positron emission tomography (PET) imagingin vivoto map the spatiotemporal biodistribution/expression (protein density) of class-IIa histone deacetylases (class-IIa HDACs) in the brain. Herein, we report an improved radiosynthesis of [18F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac0ce81330f79fde20dd19c3dd63e215
https://doi.org/10.1101/2022.11.12.516260
https://doi.org/10.1101/2022.11.12.516260
Autor:
Peter Smith-Jones, Nashaat Turkman, Grace E. Yoon, Peter J. Tonge, Labros Meimetis, Fereidoon Daryaee, Yong Li, Stephen G. Walker, Doyoung Noh, Yuanyuan Si
Publikováno v:
ACS Infectious Diseases. 6:2249-2259
Deep-seated bacterial infections caused by pathogens such as Staphylococcus aureus are difficult to diagnose and treat and are thus a major threat to human health. In previous work we demonstrated that positron emission tomography (PET) imaging with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b792b98f111d82c9b097a1f70dd036d
https://doi.org/10.1021/acsinfecdis.0c00374
https://doi.org/10.1021/acsinfecdis.0c00374
Publikováno v:
Scientific reports. 12(1)
Given our interest in the utility of liposomes for molecular imaging and theranostics, we investigated how coating the outer layer of the liposome affects internalization by breast cancer cell lines in vitro and in breast tumor tissues in vivo. Indee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a04f08e9cc5bdec2c8be95a5b8344fe6
https://pubmed.ncbi.nlm.nih.gov/35732704
https://pubmed.ncbi.nlm.nih.gov/35732704
Autor:
Robin Bonomi, Uday Mukhopadhyay, Aleksandr Shavrin, Hsien-Hsien Yeh, Anjoy Majhi, Sajeewa W Dewage, Amer Najjar, Xin Lu, G Andrés Cisneros, William P Tong, Mian M Alauddin, Ren-Shuan Liu, Thomas J Mangner, Nashaat Turkman, Juri G Gelovani
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0133512 (2015)
Histone deacetylases (HDAC's) became increasingly important targets for therapy of various diseases, resulting in a pressing need to develop HDAC class- and isoform-selective inhibitors. Class IIa deacetylases possess only minimal deacetylase activit
Externí odkaz:
https://doaj.org/article/3ab80ca33b63401587d670592377c586
Autor:
Yong, Li, Fereidoon, Daryaee, Grace E, Yoon, Doyoung, Noh, Peter M, Smith-Jones, Yuanyuan, Si, Stephen G, Walker, Nashaat, Turkman, Labros, Meimetis, Peter J, Tonge
Publikováno v:
ACS Infect Dis
Deep seated bacterial infections caused by pathogens such as Staphylococcus aureus are difficult to diagnose and treat and are thus a major threat to human health. In previous work we demonstrated that positron emission tomography (PET) imaging with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4bc934e9049b31ac8c59db013f35f1d0
https://pubmed.ncbi.nlm.nih.gov/32672928
https://pubmed.ncbi.nlm.nih.gov/32672928