The efficacy of poly-d,l-lactic acid- and hyaluronic acid-coated bone substitutes on implant fixation in sheep

Autor: Christina M. Andreasen, Susan S. Henriksen, Ming Ding, Naseem Theilgaard, Thomas L. Andersen, Søren Overgaard

Publikováno v: Journal of Orthopaedic Translation, Vol 8, Iss C, Pp 12-19 (2017)

Background/Objective: The present study investigated the efficacy of poly-d,l-lactic acid (PDLLA) and hyaluronic acid (HyA) on implant fixation when coated onto hydroxyapatite/beta-tri-calcium phosphate (HA/βTCP) granules. Methods: The effect was as

Externí odkaz: https://doaj.org/article/632d5cf9611d4d15bf631abacfe3a7ca

Assessment of activated porous granules on implant fixation and early bone formation in sheep

Autor: Søren Overgaard, Naseem Theilgaard, Ming Ding, Susan Snoek Henriksen

Publikováno v: Journal of Orthopaedic Translation
Ding, M, Snoek Henriksen, S, Theilgaard, N & Overgaard, S 2016, ' Assessment of activated porous granules on implant fixation and early bone formation in sheep ', Journal of Orthopaedic Translation, vol. 5, no. 2, pp. 38-47 . https://doi.org/10.1016/j.jot.2015.09.008
Journal of Orthopaedic Translation, Vol 5, Iss C, Pp 38-47 (2016)

Summary Background/Objective Despite recent progress in regeneration medicine, the repair of large bone defects due to trauma, inflammation and tumor surgery remains a major clinical challenge. This study was designed to produce large amounts of viab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f808f759e040d0dafbe009868ccfaa
https://doi.org/10.1016/j.jot.2015.09.008

Efficacy of a small cell-binding peptide coated hydroxyapatite substitute on bone formation and implant fixation in sheep

Autor: Ming Ding, Anders E. Jensen, Mads L. Dencker, Christina Møller Andreasen, Søren Overgaard, Naseem Theilgaard

Publikováno v: Journal of Biomedical Materials Research Part A. 103:1357-1365

Cylindrical critical size defects were created at the distal femoral condyles bilaterally of eight female adult sheep. Titanium implants with 2-mm concentric gaps were inserted and the gaps were filled with one of the four materials: allograft; a syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b749a9bbb6b00d4f9dde421f1d1658ef
https://doi.org/10.1002/jbm.a.35281

Distribution of grafted β-cyclodextrin in porous particles for bone tissue engineering

Autor: Maria V. Juhl, Jeppe Lund Nielsen, Naseem Theilgaard, Kim Lambertsen Larsen, Peter Andreas Lund Jacobsen, Jens Rafaelsen

Publikováno v: Jacobsen, P A L, Rafaelsen, J, Nielsen, J L, Juhl, M V, Theilgaard, N & Larsen, K L 2013, ' Distribution of grafted β-cyclodextrin in porous particles for bone tissue engineering ', Microporous and Mesoporous Materials, vol. 168, pp. 132-141 . https://doi.org/10.1016/j.micromeso.2012.10.001

The spatial distribution of β-cyclodextrin grafted to a range of porous materials was investigated. (3-glycidyloxypropyl)trimethoxysilane was used to facilitate the covalent grafting of β-cyclodextrin. The spatial distribution was analysed by combi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691bbfa072d78879642d3a17cfe8f6f4
https://doi.org/10.1016/j.micromeso.2012.10.001

Grafting cyclodextrins to calcium phosphate ceramics for biomedical applications

Autor: Naseem Theilgaard, Kim Lambertsen Larsen, Maria V. Juhl, Jeppe Lund Nielsen, Peter Andreas Lund Jacobsen

Publikováno v: Jacobsen, P A L, Nielsen, J L, Juhl, M V, Theilgaard, N & Larsen, K L 2012, ' Grafting cyclodextrins to calcium phosphate ceramics for biomedical applications ', Journal of Inclusion Phenomena and Macrocyclic Chemistry, vol. 72, no. 1-2, pp. 173-181 . https://doi.org/10.1007/s10847-011-9958-x

The grafting of hydroxyapatite/beta-tricalcium phosphate with β-cyclodextrin was achieved using a two step reaction with (3-glycidyloxypropyl)trimethoxysilane as a linker. Firstly, the silane group was brought to react with the hydroxyl groups at th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2cc81a677121557700ae5a0806ff289
https://doi.org/10.1007/s10847-011-9958-x