Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Naseem, Khalid"'
Autor:
Xu, Rui-Gang, Tiede, Christian, Calabrese, Antonio N., Cheah, Lih T., Adams, Thomas L., Gauer, Julia S., Hindle, Matthew S., Webb, Beth A., Yates, Daisie M., Slater, Alexandre, Duval, Cédric, Naseem, Khalid M., Herr, Andrew B., Tomlinson, Darren C., Watson, Steve P., Ariëns, Robert A. S.
Publikováno v:
In Blood Advances 13 August 2024 8(15):3917-3928
Cyclic adenosine monophosphate (cAMP)-dependent signaling modulates platelet function at sites of vascular injury. Here we show that thrombospondin-1 (TSP-1) prevents cAMP/protein kinase A (PKA) signaling through a CD36-dependent mechanism. Prostagla
Externí odkaz:
http://hdl.handle.net/10454/6155
Autor:
Drozd, Michael, Hamilton, Fergus, Cheng, Chew W., Lillie, Patrick J., Brown, Oliver I., Chaddock, Natalie, Savic, Sinisa, Naseem, Khalid, Iles, Mark M., Morgan, Ann W., Kearney, Mark T., Cubbon, Richard M.
Publikováno v:
In Journal of Infection November 2024 89(5)
Autor:
Graham, Anne M, Naseem, Khalid M., Oberprieler, Nikolaus G., Riba, Rocio, Roberts, Wayne, Homer-Vanniasinkam, Shervanthi
We examined the influence of S-nitrosoglutathione (GSNO) on alpha(IIb)beta(3) integrin-mediated platelet adhesion to immobilised fibrinogen. GSNO induced a time- and concentration-dependent inhibition of platelet adhesion. Inhibition was cGMP-indepen
Externí odkaz:
http://hdl.handle.net/10454/3313
The expression and potential role of platelet membrane CD154 and sCD154 in atherosclerosis was investigated in patients with peripheral arterial disease. This prospective observational study measured the expression of platelet-bound CD154 and soluble
Externí odkaz:
http://hdl.handle.net/10454/4118
Background: The molecular regulation of endothelial nitric oxide synthase (eNOS) in blood platelets and the signalling events induced by platelet-derived NO are poorly defined. In particular, the ability of von Willebrand factor (VWF) to stimulate cy
Externí odkaz:
http://hdl.handle.net/10454/3431
Autor:
Naseem, Khalid M., Milward, A.D., Parkin, Susan M., Patel, B., Sharifi, M., Oberprieler, Nikolaus G., Gibbins, J.M.
Summary. Background: Endothelial nitric oxide synthase (eNOS) activity in endothelial cells is regulated by post-translational phosphorylation of critical serine, threonine and tyrosine residues in response to a variety of stimuli. However, the post-
Externí odkaz:
http://hdl.handle.net/10454/3250
Elevated plasma concentrations of the sulphur-containing amino acid homocysteine (Hcy) is associated with increased risk of atherosclerosis and arterial thrombosis. The mechanism by which Hcy exerts these effects has yet to be fully elucidated, altho
Externí odkaz:
http://hdl.handle.net/10454/3839
The effects of exercise and warm-up were investigated in patients with claudication. This case-control crossover study involved two treadmill exercise tests, one preceded by a warm-up. Exercise continued until maximal leg pain (patients with claudica
Externí odkaz:
http://hdl.handle.net/10454/4147