Výsledky vyhledávání - "Naruo Katsutani"

Formation and evaluation of mechanism-based chemical categories for regulatory read-across assessment of repeated-dose toxicity: A case of hemolytic anemia

Autor: Takashi, Yamada, Tomoko, Kawamura, Shinji, Tsujii, Minoru, Miura, Hideo, Ohata, Naruo, Katsutani, Mariko, Matsumoto, Akihiko, Hirose

Publikováno v: Regulatory Toxicology and Pharmacology. 136:105275

The aim of this study is to define chemical categories that can be applied to regulatory read-across assessments for repeated-dose toxicity, by classifying toxic substances based on their structures and mechanism of actions (MoAs). Hemolytic anemia,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef2939925a30a7849d3be7e38b5b2a3
https://doi.org/10.1016/j.yrtph.2022.105275

Zobrazit plný text záznamu

Constructing a developmental and reproductive toxicity database of chemicals (DART NIHS DB) for integrated approaches to testing and assessment

Autor: Tomoko Kawamura, Akihiko Hirose, Makiko Kuwagata, Kaoru Inoue, Kazuo Ushida, Minoru Miura, Takashi Yamada, Naruo Katsutani

Publikováno v: The Journal of toxicological sciences. 46(11)

Developmental and reproductive toxicity (DART) is an important endpoint, and databases (DBs) are essential for evaluating the risk of untested substances using alternative methods. We have constructed a reliable and transparent DART DB, which we name

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6bf2913867c91a3844d501c453925a9
https://pubmed.ncbi.nlm.nih.gov/34719556

Zobrazit plný text záznamu

Combined Risk Assessment of Food-derived Coumarin with

Autor: Takashi, Yamada, Naruo, Katsutani, Taeko, Maruyama, Tomoko, Kawamura, Hiroshi, Yamazaki, Norie, Murayama, Weida, Tong, Yasushi, Yamazoe, Akihiko, Hirose

Publikováno v: Food safety (Tokyo, Japan). 10(3)

Hepatotoxicity associated with food-derived coumarin occurs occasionally in humans. We have, herein, assessed the data of existing clinical and nonclinical studies as well as those of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c9b6ee5194f36912e8684e82ef99bd6
https://pubmed.ncbi.nlm.nih.gov/36237397

Zobrazit plný text záznamu

Increases in discontinuous rib cartilage and fused carpal bone in rat fetuses exposed to the teratogens, busulfan, acetazolamide, vitamin A, and ketoconazole

Autor: Tetsuya Fukuta, I. Shiraishi, C. Kojima, E. Kato, Yasuyuki Okuda, Keiji Uchida, Toyohiko Aoki, Kazuyuki Hirano, T. Horiba, Naruo Katsutani, M. Maeda, T. Hirose, T. Dodo, Hiroshi Mineshima

Publikováno v: Human & Experimental Toxicology. 29:439-450

Skeletal changes induced by treatment of pregnant rats with four potent teratogens, busulfan, acetazolamide, vitamin A palmitate, and ketoconazole, were evaluated using Alizarin Red S and Alcian Blue double-staining to investigate the relationship be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24aeedc77cf5a5f86f5412b0ba306e8e
https://doi.org/10.1177/0960327110363862

Zobrazit plný text záznamu

Identification of Urinary Biomarkers Useful for Distinguishing a Difference in Mechanism of Toxicity in Rat Model of Cholestasis

Autor: Kenji Ishihara, Akira Inomata, Akiyoshi Suganuma, Toyohiko Aoki, Kohei Sawada, Tsuyoshi Yokoi, Yuji Uemura, Naoki Asai, Naruo Katsutani

Publikováno v: Basic & Clinical Pharmacology & Toxicology. 105:156-166

This (1)H nuclear magnetic resonance metabonomics study was aimed to determine urinary biomarkers of cholestasis resulting from inhibition of biliary secretion of bile or obstruction of bile flow. To inhibit biliary secretion of bile, cyclosporine A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd4a8bb384f3f3a37825e2c0d513386
https://doi.org/10.1111/j.1742-7843.2009.00410.x

Zobrazit plný text záznamu

A comparative investigation of fetal skeletal anomalies in rats induced by acetylsalicylic acid with single- and double-staining techniques

Autor: Toyohiko Aoki, Kazuyuki Hirano, Tetsushi Dodo, Naruo Katsutani, Hiroshi Mineshima, Fumihiro Okada, Yasuyuki Okuda, Keiji Uchida, Tetsuya Fukuta

Publikováno v: Regulatory Toxicology and Pharmacology. 54:308-313

Acetylsalicylic acid (ASA) at single doses of 125, 250, and 500 mg/kg was administered to pregnant rats on Gestation Day (GD) 10, and skeletal changes in fetuses harvested on GD 20 and pups on post-natal (PN) Day 21 were evaluated. Changes in cartila

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45777a7f56d8bfc1ae0bd4835a523179
https://doi.org/10.1016/j.yrtph.2009.05.014

Zobrazit plný text záznamu

E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor

Autor: Toshimi Okada, Nobuyuki Yasuda, Kazuto Yamazaki, Seiji Yoshikawa, Osamu Asano, Tadashi Nagakura, Osamu Takenaka, Richard Clark, Naruo Katsutani, Hironori Ikuta, Takashi Inoue, Isao Tanaka, Fumiyoshi Matsuura, Kazunobu Kira, Takao Saeki, Eita Emori

Publikováno v: European Journal of Pharmacology. 548:181-187

Dipeptidyl peptidase IV (DPP-IV) inhibitors are expected to become a useful new class of anti-diabetic agent. The aim of the present study is to characterize the in vitro and in vivo profile of E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4594c4fb6af722e43dfac4a63e9e54c8
https://doi.org/10.1016/j.ejphar.2006.08.011

Zobrazit plný text záznamu

Immunogenicity of Various Beta-Lactam Antibiotic-Protein Conjugates and Cross-Reactivity of the Antibodies Produced in Guinea Pig

Autor: Hiroshi Shionoya, Naruo Katsutani

Publikováno v: International Archives of Allergy and Immunology. 100:128-134

Immunogenic properties of bovine serum albumin (BSA) conjugates of various beta-lactam antibiotics (ABs) and cross-reactivity of the produced antibodies were investigated in guinea pigs. Each AB-BSA conjugate was immunized with complete Freund's adju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db9c6a6d517f7d9aebf20e91dbef659
https://doi.org/10.1159/000236399

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání