Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Narumol Phosrithong"'
Publikováno v:
Medicinal Chemistry Research. 26:662-671
A series of chromone derivatives have been evaluated as potential cyclooxygenase-2 (COX-2) inhibitors. The four most potent compounds, 48, 41, 39, and 35 displayed IC50 values of 3.30, 6.86, 7.36 and 7.46 µM, respectively. Compounds 35 and 38 showed
Publikováno v:
Medicinal Chemistry Research. 25:2368-2379
Lipid peroxidation has been implicated in disease states such as atherosclerosis, asthma, neurodegenerative disorders, Parkinson’s disease, cancer, etc. In this study, the anti-lipid peroxidation activity for a series of chromone compounds, evaluat
Publikováno v:
European Journal of Integrative Medicine. 8:281-285
Introduction Clerodendrum plants have been traditionally used for inflammatory related diseases in Thailand. Crude extracts of Clerodendrum disparifolium and Clerodendrum laevifolium were assessed for antioxidant and anti-inflammatory activities in o
Publikováno v:
Advanced Materials Research. 1060:124-127
DNA Topoisomerase I is an enzyme, which is involved in DNA replication, transcription and chromosome segregation in cellular processes. Inhibitors of Topoisomerase I are designed to interrupt DNA replication in cancer cells, resulting in cell death.
Autor:
Chonnawat Mongkol, Poompat Chutipanyaboot, Teedanai Rattanapit, Nawinda Chinatangkul, Nantana Nuchtavorn, Narumol Phosrithong
Publikováno v:
Advanced Materials Research. 1060:95-98
Clerodendrum disparifolium is a Thai herbal medicine, which is used for the treatment of insect bites and sting reactions by applying finely crushed leaves to the inflamed area. However, this usage is inconvenient. The study aimed to develop gel-and
Publikováno v:
Medicinal Chemistry Research. 23:1037-1045
The metal-chelating activity of a series of 48 chromone compounds, evaluated by ferrous (Fe2+) chelating test, were subjected to 3D-QSAR studies using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis
Publikováno v:
Bioorganic Chemistry. 49:9-15
The antioxidant activity for a series of chromone compounds, evaluated by DPPH free radical scavenging assay, were subjected to 3D-QSAR studies using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (
Publikováno v:
Chemical Biology & Drug Design. 79:981-989
Forty-eight chromone derivatives were evaluated for their antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay, ferrous ions (Fe(2+) ) chelating activity test, total antioxidant activity test (Ferric thiocyanate and
Publikováno v:
Medicinal Chemistry Research. 22:45-56
Several phenyl substituted chromones (also called flavonoids) have been reported to possess substantial anticancer properties; however, their modes of action have not been clearly defined. To preliminarily investigate the potential anticancer activit
Autor:
Narumol Phosrithong, Chanpen Wiwat, Jiraporn Ungwitayatorn, Patcharawee Nunthanavanit, Weerasak Samee
Publikováno v:
Journal of Molecular Structure. 1001:152-161
Novel chromone derivatives with a benzopyran-4-one scaffold have been prepared by the one-pot cyclization reaction. The in vitro inhibitory activity of these new compounds towards HIV-1 protease have been evaluated using stop time HPLC method as the