Výsledky vyhledávání - "Narumi Horita"

Akademický článek

Suppression of joint pain in transient receptor potential vanilloid 4 knockout rats with monoiodoacetate-induced osteoarthritis

Autor: Masahiko Soga, Takaya Izumi, Isamu Nanchi, Narumi Horita, Miyuki Yamamoto, Shiori Kawasaki, Koichi Ogawa, Masahide Fujita, Yasuhide Morioka

Publikováno v: PAIN Reports, Vol 6, Iss 3, p e951 (2021)

Abstract. Introduction:. Transient receptor potential vanilloid 4 (TRPV4) modulates osteoarthritic (OA) pain in animal models. However, the pathophysiological function of TRPV4 in regulating OA pain remains poorly understood. Methods:. We developed T

Externí odkaz: https://doaj.org/article/766c588121364c85aee24badfea421d5

Zobrazit plný text záznamu

Suppression of joint pain in transient receptor potential vanilloid 4 knockout rats with monoiodoacetate-induced osteoarthritis

Autor: Narumi Horita, Shiori Kawasaki, Masahiko Soga, Koichi Ogawa, Masahide Fujita, Takaya Izumi, Isamu Nanchi, Miyuki Yamamoto, Yasuhide Morioka

Publikováno v: Pain Reports
PAIN Reports, Vol 6, Iss 3, p e951 (2021)

Supplemental Digital Content is Available in the Text. Knee joint pain in osteoarthritis model rats is caused by the sensitization of transient receptor potential vanilloid 4 in the dorsal root ganglion neurons
Introduction: Transient receptor p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0951e3ec5c05714d5a4fdfba9aa31d9c
https://pubmed.ncbi.nlm.nih.gov/34396019

Zobrazit plný text záznamu

Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain

Publikováno v: Bioorganic & Medicinal Chemistry. 25:2177-2190

A novel series of (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives were identified as selective transient receptor potential vanilloid 4 (TRPV4) channel antagonist and showed analgesic effect in Freund's Complete Adjuvant (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa29140063fa0c3811b33e5cee9b2d9e
https://doi.org/10.1016/j.bmc.2017.02.047

Zobrazit plný text záznamu

Pharmacologic effects of naldemedine, a peripherally acting μ‐opioid receptor antagonist, in in vitro and in vivo models of opioid‐induced constipation

Autor: Tsuyoshi Kihara, Hiroko Ono, Toshiyuki Kanemasa, Tohko Arai, Katsumi Koike, Minoru Hasegawa, Atsushi Nakamura, Yasuhide Morioka, Narumi Horita, Hiroki Chiba

Publikováno v: Neurogastroenterology and Motility

Background Naldemedine (S‐297995) is a peripherally acting μ‐opioid receptor antagonist developed as a once‐daily oral drug for opioid‐induced constipation (OIC) in adults with chronic noncancer or cancer pain. This study characterized the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c6e64b78025e2e75fd2d9d4df99197
http://europepmc.org/articles/PMC6850587

Zobrazit plný text záznamu

Plný text ve formátu HTML

Discovery of novel 2′,4′-dimethyl-[4,5′-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 1

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 26:4930-4935

A novel series of 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives were found by high throughput screening of the TRPV4 receptor, at which these compounds showed competitive antagonist potential against 4α-phorbol 12,13-didecanoate (4αPDD) as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9dfca53a6691693d86f5736a65ec6f2
https://doi.org/10.1016/j.bmcl.2016.09.013

Zobrazit plný text záznamu

Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis

Autor: Masabumi Minami, Masayuki Imai, Minoru Hasegawa, Gaku Sakaguchi, Takeshi Yoshioka, Narumi Horita, Atsushi Morita, Junji Tsuchida, Yasuhide Morioka, Mikie Hinata, Kenichi Higashino, Shoji Yamane, Isao Fukuda, Masahiko Soga, Takao Sanaki, Minoru Ikeda, Toshiyuki Kanemasa, Miyuki Yamamoto, Sunao Imai

Publikováno v: Pain. 159(5)

Transient receptor potential vanilloid 4 (TRPV4) receptor modulates pain, and this has been noted in several animal models. However, the involvement of TRPV4 in osteoarthritic (OA) pain remains poorly understood. This study assessed the functional ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd117c6492d9838952d160f17582672e
https://pubmed.ncbi.nlm.nih.gov/29438227

Zobrazit plný text záznamu

Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 2

Publikováno v: Bioorganicmedicinal chemistry letters. 26(20)

A series of 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives have been identified as selective TRPV4 antagonists that display inhibition potencies against 4α-phorbol 12,13-didecanoate (4αPDD), well known as a TRPV4 selective agonist and/or a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07851f926e3ee62eead1648e33994ed6
https://pubmed.ncbi.nlm.nih.gov/27634196

Zobrazit plný text záznamu

Akademický článek

Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis.

Publikováno v: PAIN; May2018, Vol. 159 Issue 5, p939-947, 9p

Zobrazit plný text záznamu

Effects of Naldemedine: A Peripherally Acting Mu-Opioid Receptor Antagonist in Rat Models of Opioid-Induced Constipation

Autor: Katsumi Koike, Tsuyoshi Kihara, Toshiyuki Kanemasa, Tohko Arai, Hiroki Chiba, Narumi Horita, Minoru Hasegawa

Publikováno v: American Journal of Gastroenterology. 110:S578

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aea20f5f379e5ffdb0232761f26f63c0
https://doi.org/10.14309/00000434-201510001-01322

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání