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Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

Autor: Hill, Michael D, Goyal, Mayank, Menon, Bijoy K, Nogueira, Raul G, McTaggart, Ryan A, Demchuk, Andrew M, Poppe, Alexandre Y, Buck, Brian H, Field, Thalia S, Dowlatshahi, Dar, van Adel, Brian A, Swartz, Richard H, Shah, Ruchir A, Sauvageau, Eric, Zerna, Charlotte, Ospel, Johanna M, Joshi, Manish, Almekhlafi, Mohammed A, Ryckborst, Karla J, Lowerison, Mark W, Heard, Kathy, Garman, David, Haussen, Diogo, Cutting, Shawna M, Coutts, Shelagh B, Roy, Daniel, Rempel, Jeremy L, Rohr, Axel CR, Iancu, Daniela, Sahlas, Demetrios J, Yu, Amy Y X, Devlin, Thomas G, Hanel, Ricardo A, Puetz, Volker, Silver, Frank L, Campbell, Bruce C V, Chapot, René, Teitelbaum, Jeanne, Mandzia, Jennifer L, Kleinig, Timothy J, Turkel-Parrella, David, Heck, Donald, Kelly, Michael E, Bharatha, Aditya, Bang, Oh Young, Jadhav, Ashutosh, Gupta, Rishi, Frei, Donald F, Tarpley, Jason W, McDougall, Cameron G, Holmin, Staffan, Rha, Joung-Ho, Puri, Ajit S, Camden, Marie-Christine, Thomalla, Götz, Choe, Hana, Phillips, Stephen J, Schindler, Joseph L, Thornton, John, Nagel, Simon, Heo, Ji Hoe, Sohn, Sung-Il, Psychogios, Marios-Nikos, Budzik, Ronald F, Starkman, Sidney, Martin, Coleman O, Burns, Paul A, Murphy, Seán, Lopez, George A, English, Joey, Tymianski, Michael, Demchuk, Andrew, Barber, Philip, Smith, Eric, Bal, Simerpreet, Subramaniam, Suresh, Peters, Steven, Couillard, Phillippe, Klein, Gary, Stys, Peter, Menon, Bijoy, Coutts, Shelagh, Almekhlafi, Mohammed, Hill, Michael, Goyal, Mayank, Wong, John, Mitha, Alim, Eesa, Muneer, Morrish, William, Alqatani, Saad, Kashani, Nima, Joshi, Manish, Zerna, Charlotte, Ospel, Johanna, Venkatesan, Prasanna, Teleg, Erika, Sitaram, Amith, Graham, Brett, Van Gaal, Stephen, Moussaddy, Aimen, Chakraborty, Debabrata, Maraj, Nicholas, Loockey, Andrew, Chen, Shuo, Singh, Ravinder, Alsultan, Abdulaziz, Asuncion, Ria, Tse, Dominic, Doshi, Darshan, Volny, Ondrej, Ojha, Piyush, Wadhwa, Ankur, Marko, Martha, Singh, Nishita, Wasyliw, Sanchea, Ryckborst, Karla, Kenney, Carol, Save, Supriya, Jambula, Anitha, Newcommon, Nancy, Hull, Gavin, Blackstock, Darcy, Kiszczak, Sharon, Zimmel, Leslie, Wright, Michelle, Jahraus, Cari, Andersen, Linda, Bohn, Shelly, Paul, Joseph, Zhang, Oiao, Doram, Craig, Lowerison, Mark, Hanley, Andrea, Campbell, Lori, Ure, Ashley, Taylor, Francis, Hul, Dominic, Wiebe, Samuel, Saluzzi, Marina, Blenkin, Nicole, Frayne, Richard, Buck, Brian, Butcher, Kenneth, Shuaib, Ashfaq, Jeerakathil, Tom, Jickling, Glen, Emery, Derek, Rempel, Jeremy, Owen, Richard, Ashforth, Robert, Yeo, Tom, Kotylak, Trevor, O'Kelly, Cian, Chow, Michael, Siddiqui, Muzaffer, Saqqur, Maher, D'Souza, Atlantic, Lloret, Mar, Butt, Asif, Nomani, Ali, Kalashyan, Hayrapet, Thirunavukkarasu, Sibi, Jabs, Juline, Fairall, Paige, Piquette, Lori, Phillips, Stephen, Green, A. Laine, Gubitz, Gordon, Heidenreich, Jens, Huynh, Thien, Shankar, Jai, Maloney, William, Vandorpe, Robert, Schmidt, Matthias, Pickett, Gwynedd, Weeks, Adrienne, Jarrett, Judith, MacDonald, Debbie, Arsenault, Joanna, Kinnear, Ruth, Mandzia, Jennifer, Mayich, Michael, Boulton, Melfort, Bullrich, Maria, Fridman, Sebastian, Kiwan, Ruba, Lee, Donald, Lownie, Stephen, Khaw, Alexander, Pandey, Sachin, Sharma, Manas, Sposato, Luciano, Wade, Kevin, Beauchamp, Beth, Lambourn, Lindsay, Amato-Marziali, Belinda, Poppe, Alexandre, Roy, Daniel, Daneault, Nicole, Deschaintre, Yan, Gioia, Laura, Jacquin, Grégory, Odier, Céline, Stapf, Christian, Iancu, Daniela, Raymond, Jean, Weill, Alain, Lapierre, Marlène, Jadil, Nadia, Jolteus, Judlène, Teitelbaum, Jeanne, Angle, Mark, Hannouche, Mathew, Badawy, Mohamed, Letourneau, Justin, Cortes, Maria, Linnell, Grant, Tampieri, Donateela, Vieira, Lucy, Moussaddy, Aimen, Legault, Catherine, Durcan, Liam, Moore, Angela, Cole, Erin, Magnussen, Claire, Salmon, Kristiana, Khalil, Salma, Desloges, Isabelle, Waxman, Lindsay, Abdon, Wynne, Lai, Sonia, Dowlatshahi, Dar, Iancu, Daniela, Shamy, Michel, Stotts, Grant, Blacquiere, Dylan, Lesiuk, Howard, Quateen, Aiman, Drake, Brian, Dewar, Brian, Daham, Zeinab, Kelly, Michael, Hunter, Gary, Peeling, Lissa, Graham, Brett, Whelan, Ruth, Garner, Aaron, Urroz, Lilian, Maley, Sharleen, Silver, Frank, Casaubon, Leanne, Pikula, Aleksandra, Del Campo, Martin, Schaafsma, Joanna, Jaigobin, Cheryl, Krings, Timo, Pereira, Vitor, Agid, Ronit, Farb, Richard, Kalman, Libby, Cayley, Anne, Williams, Janice, Stewart, Tim, Misquitta, Karen, Bharatha, Aditya, Selchen, Daniel, Marotta, Thomas, Sarma, Dipanka, Montanera, Walter, Spears, Juluan, Saposnik, Gustavo, Kostyrko, Pawel, Li, Yangmei, Parra-Farina, Carmen, Bengzon Diestro, Jose Danilo, Camden, Marie-Christine, Verreault, Steve, Mackey, Ariane, Audet, Marie-Eve, Milot, Geneviève, Lavoie, Pascale, Gariépy, Jean-Luc, Collard, Karine, Haché, Annette, Van Adel, Brian, Sahlas, Demetrios, Alshanbari, Ahmed, Baldwin, Josephine, Catanese, Luciana, Chen, Bing, De Sa Boasquevisque, Danielle, Deshmukh, Aviraj, Knapman, Jordan, Lamers, Shana, Larrazabal, Ramiro, MacMillan, Susan, Mai, Lauren, Mattia, Alicia, Nayar, Sumiti, Ng, Kuan, Oczkowski, Wieslaw, Perera, Kanjana, Shawawrah, Mays, Shoamanesh, Ashkan, Sobhi, Gita, Syed, Nabeel, Taher, Noran, Vandervelde, Cheyanne, Wang Pharm, Di, Field, Thalia, Van Gaal, Stephen, Teal, Philip, Benavente, Oscar, Wilson, Laura, Mann, Sharanpal, Yip, Samuel, Murphy, Colleen, Heran, Manraj, Rohr, Axel, Settecase, Fabio, Redekop, Gary, Haw, Charles, Maclean, Genoveva, Murray, Karina, Chiu, Rosalin, Flexman, Alana, Strecha, Eilidh, Gayton, Yolanda, Yip, Judy, Swartz, Richard, Boulos, Mark, Gladstone, David, Yu, Amy, Hopyan, Julia, Khosravani, Houman, Manosalva Alzate, Herbert, Southwell, Alisia, Kamra, Maneesha, Lopes, Kaitlyn, Kapoor, Arunima, da Costa, Leodante, Yang, Victor, Dyer, Erin, Shah, Ruchir, Knowles, Brenda, Nichols, Jennifer, Patterson, Jennifer, Cope, Krista, Dickerson, Lee, Barton, Katrina, Gray, Kimberly, Massengale, Ticey, Miller, Melanie, Simpson, Cindy, Walker, Sabrina, Tennyson-Yemm, Chlin, Devlin, Thomas, Frei, Donald, Bellon, Richard, Atchie, Benjamin, Kaminsky, Ian, Wilson, Duandelyn, Schraeder, Nicolle, Arias, Eric, Kodis, Lisa, Talley, Mark, Edinger, Alex, Talley, Tiffany, Dempsey, Ita, Williams, Laurie, Williams, Scott, Kupniewski, Sonny, Fasbinder, Brad, Snead, Joanna, Choe, Hana, Mackenzie, Larami, Weisman, Davi, Kozak, Osman, Shah, Qaisar, Gzesh, Dan, Kulandaivel, Kandan, Khoury, John, Klein, Brad, Bussinger, Patricia, Griffin, Lisa, dePalmo, Ashley, Oliva, Cynthia, Jadhav, Ashutosh, Jovin, Tudor, Kenmuir, Cynthia, Jankowitz, Brian, Gross, Bradley, Rocha, Marcelo, Starr, Matthew, Brown, Merritt, Hawkes, Christine, Shah, Kavit, Tememe, Danoushka, Walker, Gregory, Patel, Pratit, Klein, Bradley, Ziayee, Habibullah, Limaye, Kaustubh, Baxendell, Lisa, Gilchrist, Vicki, Feineigle, Patricia, Toseki Haibach, Kelsea, Van Every, Cathy, Desai, Shashyat, Zulfiqar, Maryam, Gibson, Linda, Barrett, Sean, Turkel-Parrella, David, Arcot, Karthikeyan, DiCrescento, Steven, Farkas, Jeffrey, Filipowski, Gregory, Frontera, Jennifer, Joset, Danielle, Liff, Jeremy, Scher, Erica, McDougall, Cameron, Kelly, Cheryl, Patel, Akshal, Monteith, Stephen, Starkman, Sidney, Atchaneeyasakul, Kunakorn, Burgos, Adrian, Chua, Janice Anne, Gaines, Nathan, Grunberg, Ileana, Guzy, Judy, Liu, Zuolu, Maluste, Neil, Ramirez, Lucas, Sharma, Latisha, Heck, Donald, Brown, Morry, McDonald, Colin, Calderon, Mateo, Hargis, Mitch, Roels, Christina, Emmady, Prabhu, Alvi, Talat, McTaggart, Ryan, Jayaraman, Mahesh, Cutting, Shawna, Smith, Wendy, Foley, Susan, Paolucci, Gino, Has, Richard, Quinn, Katie, Fuller, Lindsey, Brierley, Rebecca, Watkins, Christina, Demir, Nicole, Lopez, George, Vargas, Alejandro, Osteraas, Nicholas, Holtz, Becky, Sauvageau, Eric, Hanel, Ricardo, Aghaebrahim, Amin, Chmayssani, Mohamad, Naval, Neeraj, Day, Jason, Dellorso, Scott, Ludwig, Benjamin, Schemmel, Derek, Ebreo, Nancy, Bell, Karen, Lewis, Lanai, Delucia, Marjorie, Nogueira, Raul, Haussen, Diogo, Frankel, Michael, Bhatt, Nirav, Bianchi, Nicolas, Anderson, Aaron, Belagaje, Samir, Liberato, Bernardo, Rangaraju, Srikant, Al-Bayati, Alhamza, Grossberg, Jonathan, Craft, Leah, Schindler, Kiva, Schaad, Erin, Schultz, Meagan, Southerly, Lorretta, Doppelheuer, Shannon, Charlton, Jacquelyn, Faggard, Jason, Barbret, Zuzana, DukSoo Han, Ethan, Walters, Robin, Dolia, Jaydevsinh, El-Jamal, Sleiman, Eby, Brendan, Saleem, Yasir, Pearl, Harrison, Patel, Kishan, Rahman, Haseeb, Butt, Reema, English, Stephen, Puri, Ajit, Howk, Mary, Singh, Jasmeet, Massari, Francesco, DeMacedo Rodrigues, Katyucia, Kuhn, Anna, English, Joey, Barazangi, Nobl, Telischak, Nick, Kim, Warren, Ross, Josh, DeVole, Nata, Redford, Jessica, Ferreira, Milena, Ponting, Katie, Shen, Helen, Bedenk, Ann, Patel, Susila, Fernandess, Julia, Ke, Michael, Spokoyny, Ilanit, Gao, Billy, Tong, David, Chen, Charlene, Wong, Christine, Choe, Jessica, Martin, Coleman, Summers, Debbie, Boutwell, Christine, Olds, Karin, Crandall, Suzanne, Eatman, John, Akhtar, Naveed, Holloway, William, Halpin, Jared, Donegan, Brett, Schindler, Joseph, Hwang, David, Gilmore, Emily, Petersen, Nils, Sheth, Kevin, Brown, Stacy, Beekman, Rachel, George, Benjamin, Kaddouh, Firas, Falcone, Guido, Wira, Charles, Matouk, Charles, Loomis, Caitlin, Amin, Hardik, Stretz, Hans Christoph, Narula, Reshma, Jasne, Adam, Sansing, Lauren, Agarwal, Tijil, Jasak, Sara, Fontaine, Briana, King, Zachary, Kuohn, Lindsey, Orgass, Hailey, Leary, Megan, Nye, Joan, Halbert, Kelsey, Nystrom, Karin, Neuschatz, Kaile, Petrucci, Dawn, Coppola, Anna, Tarpley, Jason, Joyce, Treasure, Hou, Sam, Umekubo, Mark, Nakamura, Catrice, Ovando, Renee, Zuniga, Diana, Nien, Yih Lin, Basto, Fernando Mayor, Arch, Allison, Jong, Laura, Conrad, William, Abbott, Tara, Yao, Jay, Caganap, Scott, Jordan, John, Teitelbaum, George, Darflinger, Robert, Gupta, Rishi, Bain, Marianne, Budzik, Ronald, Czerniak, Jennifer, Groezinger, Katherine, Hicks II, William, Kaskar, Omran, Katz, Brian, Loochtan, Aaron, Pema, Peter, Rai, Vivek, Vora, Nirav, Brown, Amanda, Goodman, Diane, Danenbergs, Barb, Gossett, Monica, Bang, Oh Young, Chung, Jong-Won, Jeon, Pyoung, Kim, Keon Ha, Lim, Yun Jeong, Heo, Ji Hoe, Nam, Hyo Suk, Kim, Young Dae, Park, HyungJong, Hwang, In Gun, Ha, Wooseok, Choi, Jin Kyo, Jeong, Kyungsun, Rha, Joung-Ho, Park, Hee-Kwon, Yoon, Cindy, Kim, Bo-Kyung, Sohn, Sung-Il, Kim, Chang-hyun, Yoo, Joonsang, Hong, Jeong-Ho, Park, Hyungjong, Kim, Sohyeon, Choi, Moonkyung, Bae, Hyoeun, Lee, Jun Seok, Lee, Jae-Joon, Jun, Go-Eun, Jeon, Sujeong, Campbell, Bruce, Mitchell, Peter, Yassi, Nawaf, Davis, Stephen, Donnan, Geoffrey, Parsons, Mark, Yan, Bernard, Dowling, Richard, Bush, Steven, Wu, Teddy, Shah, Darshan, Zhao, Henry, Salvaris, Patrick, Alemseged, Fana, Ng, Felix, Williams, Cameron, Balabanski, Anna, Dos Santos, Angela, Ng, Jo-Lyn, McDonald, Amy, Jackson, David, Tsoleridis, Jessica, Pesavento, Lauren, Kleinig, Timothy John, Nurs, Roy Drew, Cranefield, Jennifer, Scroop, Rebecca, Cagi, Lavenia, Harvey, Jackson, Waters, Michael, Thornton, John, Brennan, Robert, O'Hare, Alan, Power, Sarah, Williams, David, Boyle, Karl, Moynihan, Barry, Liddy, Ann-Marie, Large, Margaret, Cullen, Ailbhe, Walsh, Roisin, Martin, Emma, Lynch, Julie, McElroy, Sinéad, Murphy, Seán, Coveney, Sarah, Deegan, Caroline, Horgan, Gillian, Kelly, Peter, Laffan, Aoife, Llamas-Osorio, Yudy, Lynch, Catherine, Mac Mahon, Peter, Marnane, Michael, McCabe, John, Burns, Paul, Tauro, Suzanne, Cuddy, Sarah, Rennie, Ian, Smyth, Graham, Flynn, Peter, Wiggam, Ivan, Kerr, Enda, Gordon, Patricia, Fearon, Patricia, Roberts, Geralt, Patterson, Cathy, Adams, Karen, Wells, Brian, McFarland, Margaret, Holmin, Staffan, Moreira, Tiago, Sjöstrand, Christina, Mazya, Michael, Almqvist, Håkan, Wahlgren, Nils, Steinberg, Anna, Cooray, Charith, Eriksson, Einar, Thorén, Magnus, Keselman, Boris, Ahmed, NIaz, Holmberg, Åke, Axelsson, Maria, Berglund, Annika, Thomalla, Götz, Golsari, Amir, Hoppe, Julia, Deb-Chatterji, Milani, Cheng, Bastian, Barrow, Ewgenia, Schlemm, Eckhard, Lettow, Iris, Jensen, Märit, Otto, Dagmar, Jaramillo, Kirsten, Appelbohm, Hannes, Fiehler, Jens, Bester, Maxim, Schönfeld, Michael, Brekenfeld, Caspar, Holst, Brigitte, Wortmann, Ginette, Koch, Friederike, Puetz, Volker, Gerber, Johannes, Abramyuk, Andrij, Kaiser, Daniel, Winzer, Simon, Prakapenia, Alexandra, Pallesen, Lars-Peder, Siepmann, Timo, Barlinn, Kristian, Haase, Kathrin, Sauer, Angela, Psychogios, Marios-Nikos, Liman, Jan, Brehm, Alex, Maus, Volker, Hollstein, Nicole, Reinke, Annika, Neitz, Gustav, Schnieder, Marlena, Schwarz, Margret, Ibrahim, Allam, Müller, Julia, Meister, Stefanie, Bäumle, Berit, Chapot, René, Pilgram-Pastor, Sara, Wallocha, Marta, Stauder, Michael, Celik, Ekin, Stracke, Paul, Müller, Nicole, Weber, Ralph, Velktamp, Roland, Nagel, Simon, Ringleb, Peter Arthur, Heyse, Miriam, Amiri, Hemasse, Mundiyanapurath, Sibu, Chen, Min, Bevrle, Elisabeth, Beck, Perdita, Möhlenbruch, Markus alfred, Tymianski, Michael, Potvin, Alphonse, Harris, Cameron, Wang, Chong, Adams, Corey, Mayor, Diana, Garman, Dave, Chau, Davis, Wu, Jane, Lunn, Janet, Heard, Kathy, Bermanis, Liat, Teyes, Lucy, Constant, Marc, Galsim, Maria, Helbin, Michael, Leroux, Michelle, Felix, Nicole, Bendre, Nilima, Cuthbert, Sandra, Brokx, Steve, Zhang, Yichuan, Lingham, Trudy, Kohli, Yatika, Salter, Michael, Liebeschuetz, Joseph, Hofmann, Frieder, Constant, John, Soeder, Tom, Snoke, Kara, Bologa, Monica, Stahl, Kimberly, Graziewicz, Maria

Publikováno v: The Lancet; March 2020, Vol. 395 Issue: 10227 p878-887, 10p

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